Propanamide, 3,3'-(octylimino)bis[N-phenyl-
- CAS No.
- 1621535-90-7
- Chemical Name:
- Propanamide, 3,3'-(octylimino)bis[N-phenyl-
- Synonyms
- UCM-1336;UCM 1336,UCM1336;UCM-1336, 10 mM in DMSO;3,3′-(Octylimino)bis[N-phenylpropanamide];Propanamide, 3,3'-(octylimino)bis[N-phenyl-;3,3'-(Octylazanediyl)bis(N-phenylpropanamide);3,3'-(Octylazanediyl)bis(N-phenylpropanamide)
- CBNumber:
- CB010174726
- Molecular Formula:
- C26H37N3O2
- Molecular Weight:
- 423.59
- MDL Number:
- MOL File:
- 1621535-90-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
Propanamide, 3,3'-(octylimino)bis[N-phenyl- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0890407 | UCM-1336 99.86% | 1621535-90-7 | 5mg | $54 | 2026-06-04 | Buy |
| ChemScene | CS-0890407 | UCM-1336 99.86% | 1621535-90-7 | 10mg | $92 | 2026-06-04 | Buy |
| ChemScene | CS-0890407 | UCM-1336 99.86% | 1621535-90-7 | 25mg | $190 | 2026-06-04 | Buy |
| ChemScene | CS-0890407 | UCM-1336 99.86% | 1621535-90-7 | 50mg | $303 | 2026-06-04 | Buy |
| ChemScene | CS-0890407 | UCM-1336 99.86% | 1621535-90-7 | 100mg | $487 | 2026-06-04 | Buy |
Propanamide, 3,3'-(octylimino)bis[N-phenyl- Chemical Properties, Uses, Production
Description
UCM-1336 is a potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor ( IC50 = 2 μM). UCM-1336 improves survival in Ras-driven acute myeloid leukemia. UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. In addition, it induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia.
Uses
UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1].
References
[1] Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62(13):6035-6046. DOI:10.1021/acs.jmedchem.9b00145
Propanamide, 3,3'-(octylimino)bis[N-phenyl- Preparation Products And Raw materials
Raw materials
Preparation Products
Propanamide, 3,3'-(octylimino)bis[N-phenyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | cis@bioss.com.cn | China | 9185 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| Hubei wei shi reagent group ltd., company | 17771898297 13125137661 | 2853877621@qq.com | China | 7992 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-5885952 15955137747 | sales@aikonchem.com | China | 8012 | 58 |
