ChemicalBook >> CAS DataBase List >>2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)-

2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)-

2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- structure

CAS No.: 1984824-54-5

Chemical Name:: 2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)-

Synonyms: GDC-0334;2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)-

CBNumber:: CB010473403

Molecular Formula:: C24H19F8N5O3S

Molecular Weight:: 609.49

MDL Number:

MOL File:: 1984824-54-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:27

Request For Quotation

2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- Properties

Density	1.58±0.1 g/cm3(Predicted)
pka	12.33±0.60(Predicted)
FDA UNII	CZ9KU41DVB

2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- Chemical Properties, Uses, Production

Uses

GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma[1][2].

IC 50

TRPA1

References

[1] Estrada A, et al. 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists. WO2016128529 A1.
[2] Balestrini A, et.al A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment. J Exp Med. 2021 Apr 5;218(4):e20201637. DOI:10.1084/jem.20201637

2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- Suppliers

Global Suppliers ( 5)

Supplier	Tel	Email	Country	ProdList	Advantage
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	7236	62
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
DC Chemicals	021-58447131 13564518121	doncunbiosci@gmail.com	China	618	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5985	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62
BOC Sciences	65
DC Chemicals	58
Nantong QuanYi Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58

1984824-54-5 (2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)-) Related Search:

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2-Pyrrolidinecarboxamide, 4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-[[5-(trifluoromethyl)-2-[2-(trifluoromethyl)-5-pyrimidinyl]-4-pyridinyl]methyl]-, (2S,4R,5S)- GDC-0334 1984824-54-5 C24H19F8N5O3S