3-Hydroxypyridine-4-carboxaldehyde
- CAS No.
- 1849-54-3
- Chemical Name:
- 3-Hydroxypyridine-4-carboxaldehyde
- Synonyms
- 4-FORMYL-3-HYDROXYPYRIDINE;3-HYDROXY-ISONICOTINALDEHYDE;3-Hydroxypyridin-4-carbaldehyde;3-HYDROXY-PYRIDINE-4-CARBALDEHYDE;3-HYDROXYPYRIDINE-4-CARBOXALDEHYDE;3-Hydroxy-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 3-hydroxy-;3-Hydroxypyridine-4-carboxaldehyde ISO 9001：2015 REACH;4-Formyl-3-hydroxypyridine 3-Hydroxy-isonicotinaldehyde
- CBNumber:
- CB0108328
- Molecular Formula:
- C6H5NO2
- Molecular Weight:
- 123.11
- MDL Number:
- MFCD01318565
- MOL File:
- 1849-54-3.mol
| Melting point | 126-128 °C |
|---|---|
| Boiling point | 323.8±22.0 °C(Predicted) |
| Density | 1.327±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | pK1:4.05(＋1);pK2:6.77(OH) (25°C) |
| color | Cream |
| InChI | InChI=1S/C6H5NO2/c8-4-5-1-2-7-3-6(5)9/h1-4,9H |
| InChIKey | NVLPDIRQWJSXLZ-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(C=O)=C1O |
| CAS DataBase Reference | 1849-54-3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39-24/25 |
| HS Code | 29333990 |
3-Hydroxypyridine-4-carboxaldehyde price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H947165 | 3-Hydroxypyridine-4-carboxaldehyde | 1849-54-3 | 1g | $250 | 2021-12-16 | Buy |
| Matrix Scientific | 072073 | 3-Hydroxypyridine-4-carboxaldehyde 95+% | 1849-54-3 | 1g | $333 | 2021-12-16 | Buy |
| ChemScene | CS-W005203 | 3-Hydroxypyridine-4-carboxaldehyde >98.0% | 1849-54-3 | 1g | $145 | 2021-12-16 | Buy |
| Matrix Scientific | 072073 | 3-Hydroxypyridine-4-carboxaldehyde 95+% | 1849-54-3 | 250mg | $167 | 2021-12-16 | Buy |
| ChemScene | CS-W005203 | 3-Hydroxypyridine-4-carboxaldehyde >98.0% | 1849-54-3 | 5g | $424 | 2021-12-16 | Buy |
3-Hydroxypyridine-4-carboxaldehyde Chemical Properties,Uses,Production
Synthesis
666234-13-5
1849-54-3
To a stirred solution of 3-methoxymethoxypyridine-4-carboxaldehyde (11.0 g, 65.83 mmol) in tetrahydrofuran (THF, 50 mL) was added 3 N hydrochloric acid (HCl, 100 mL) and the reaction mixture was stirred for 1 h at 60 °C. The reaction was carried out in an ice bath. Upon completion of the reaction, the mixture was cooled in an ice bath and the pH was adjusted with solid potassium carbonate (K2CO3) to 7. Subsequently, the mixture was extracted with ethyl acetate (EtOAc, 5 × 250 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (100-200 mesh) with 23% ethyl acetate/hexane as eluent to give 3-hydroxypyridine-4-carboxaldehyde (4.0 g, 32.496 mmol, 49.4% yield) as a light yellow solid. The product was analyzed by GC-MS showing a molecular ion peak of 123 (m/z), and the 1H-NMR (DMSO-d6, 400 MHz) data were as follows: δ 11.04 (broad single peak, 1H), 10.37 (single peak, 1H), 8.46 (single peak, 1H), 8.20 (double peak, 1H, J = 4.88 Hz), and 7.46 (double peak, 1H, J = 4.88 Hz).The purity of GC-FID analysis was 99.51%.
References
[1] Patent: WO2016/27241, 2016, A1. Location in patent: Page/Page column 30; 43
[2] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 146
3-Hydroxypyridine-4-carboxaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Nanjing Fred Technology Co., Ltd. | +86-02584696168 15380713688 | Austin@fredchem.cn | CHINA | 865 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20601 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from 3-Hydroxypyridine-4-carboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-09-27 | 3-Hydroxypyridine-4-carboxaldehyde
1849-54-3
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-06 | 3-Hydroxypyridine-4-carboxaldehyde
1849-54-3
|
US $1.00 / KG | 1KG | 95% | 500KG | Career Henan Chemical Co |
-
- 3-Hydroxypyridine-4-carboxaldehyde
1849-54-3
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 3-Hydroxypyridine-4-carboxaldehyde
1849-54-3
- US $1.00 / KG
- 95%
- Career Henan Chemical Co
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