3-Hydroxypyridine-4-carboxaldehyde
- CAS No.
- 1849-54-3
- Chemical Name:
- 3-Hydroxypyridine-4-carboxaldehyde
- Synonyms
- 4-FORMYL-3-HYDROXYPYRIDINE;3-HYDROXY-ISONICOTINALDEHYDE;3-Hydroxypyridin-4-carbaldehyde;3-HYDROXY-PYRIDINE-4-CARBALDEHYDE;3-HYDROXYPYRIDINE-4-CARBOXALDEHYDE;3-Hydroxy-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 3-hydroxy-;3-Hydroxypyridine-4-carboxaldehyde ISO 9001：2015 REACH;4-Formyl-3-hydroxypyridine 3-Hydroxy-isonicotinaldehyde
- CBNumber:
- CB0108328
- Molecular Formula:
- C6H5NO2
- Molecular Weight:
- 123.11
- MDL Number:
- MFCD01318565
- MOL File:
- 1849-54-3.mol
- MSDS File:
- SDS
| Melting point | 126-128 °C |
|---|---|
| Boiling point | 323.8±22.0 °C(Predicted) |
| Density | 1.327±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | pK1:4.05(+1);pK2:6.77(OH) (25°C) |
| color | Cream |
| InChI | InChI=1S/C6H5NO2/c8-4-5-1-2-7-3-6(5)9/h1-4,9H |
| InChIKey | NVLPDIRQWJSXLZ-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(C=O)=C1O |
| CAS DataBase Reference | 1849-54-3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39-24/25 |
| HS Code | 29333990 |
3-Hydroxypyridine-4-carboxaldehyde price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-H947165-2.5G | 3-Hydroxypyridine-4-carboxaldehyde | 1849-54-3 | 2.5g | $772 | 2026-06-03 | Buy |
| Biosynth | FH140303 | 3-Hydroxyisonicotinaldehyde | 1849-54-3 | 5g | $562.5 | 2026-06-04 | Buy |
| Biosynth | FH140303 | 3-Hydroxyisonicotinaldehyde | 1849-54-3 | 10g | $756.3 | 2026-06-04 | Buy |
| Biosynth | FH140303 | 3-Hydroxyisonicotinaldehyde | 1849-54-3 | 25g | $1306.25 | 2026-06-04 | Buy |
| Biosynth | FH140303 | 3-Hydroxyisonicotinaldehyde | 1849-54-3 | 50g | $2000 | 2026-06-04 | Buy |
3-Hydroxypyridine-4-carboxaldehyde Chemical Properties, Uses, Production
Uses
3-Hydroxypyridine-4-aldehyde is an aldehyde organic compound, mainly used as a pharmaceutical intermediate.
Application
In basic organic chemistry research, 3-hydroxypyridine-4-aldehyde can be used as a synthetic raw material for organic ligands for the structural modification and synthesis of pyridine ligands. By modifying the compound with different functional groups, its electronic properties, stereochemical properties, etc. can be changed, thus modulating the properties of the synthesized organic ligands. In addition, 3-hydroxypyridine-4-aldehyde can be used as a pyridine-like substrate for evaluating the applicability of newly developed synthetic methods and optimization of reaction conditions.
Synthesis
666234-13-5
1849-54-3
To a stirred solution of 3-methoxymethoxypyridine-4-carboxaldehyde (11.0 g, 65.83 mmol) in tetrahydrofuran (THF, 50 mL) was added 3 N hydrochloric acid (HCl, 100 mL) and the reaction mixture was stirred for 1 h at 60 °C. The reaction was carried out in an ice bath. Upon completion of the reaction, the mixture was cooled in an ice bath and the pH was adjusted with solid potassium carbonate (K2CO3) to 7. Subsequently, the mixture was extracted with ethyl acetate (EtOAc, 5 × 250 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (100-200 mesh) with 23% ethyl acetate/hexane as eluent to give 3-hydroxypyridine-4-carboxaldehyde (4.0 g, 32.496 mmol, 49.4% yield) as a light yellow solid. The product was analyzed by GC-MS showing a molecular ion peak of 123 (m/z), and the 1H-NMR (DMSO-d6, 400 MHz) data were as follows: δ 11.04 (broad single peak, 1H), 10.37 (single peak, 1H), 8.46 (single peak, 1H), 8.20 (double peak, 1H, J = 4.88 Hz), and 7.46 (double peak, 1H, J = 4.88 Hz).The purity of GC-FID analysis was 99.51%.
References
[1] Patent: WO2016/27241, 2016, A1. Location in patent: Page/Page column 30; 43
[2] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 146
3-Hydroxypyridine-4-carboxaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Chenzhu Pharmaceutical Co., Ltd. | 13162380607 | 1696175688@qq.com | China | 834 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Shanghai Hope Chem Co., Ltd.， | +21-18501659228 18501659228 | info@hope-chem.com | China | 538 | 55 |
| Suzhou Sibian Chemical Technology Co.,Ltd. | 0512-65617459 18915409046 | sales@sibian-chem.com | China | 1917 | 55 |
View Latest Price from 3-Hydroxypyridine-4-carboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 3-Hydroxypyridine-4-carboxaldehyde
1849-54-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-06 | 3-Hydroxypyridine-4-carboxaldehyde
1849-54-3
|
$1.00 | 1KG | 95% | 500KG | Career Henan Chemical Co |
-
- 3-Hydroxypyridine-4-carboxaldehyde
1849-54-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-Hydroxypyridine-4-carboxaldehyde
1849-54-3
- $1.00
- 95%
- Career Henan Chemical Co
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