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ChemicalBook >> CAS DataBase List >>6-Nitro-7-Chloro-4-HydroxyQuinazoline

6-Nitro-7-Chloro-4-HydroxyQuinazoline

6-Nitro-7-Chloro-4-HydroxyQuinazoline Structure
6-Nitro-7-Chloro-4-HydroxyQuinazoline structure
CAS No.
53449-14-2
Chemical Name:
6-Nitro-7-Chloro-4-HydroxyQuinazoline
Synonyms
Mefatinib Impurity 13;7-chloro-6-nitroquinazolin-4-ol;7-Chloro-6-nitro-4-quinazolinol;7-Chloro-6-nitroquinazolin-4(3H);7-Chloro-6-nitroquinazolin-4-one;7-Chloro-6-nitro-4-quinazolinone;7-CHLORO 6-NITRO QUINAZOLINE 4-OL;7-Chloro-6-nitro-4(3H)quinazolinone;6-Nitro-7-Chloro-4-HydroxyQuizoline;7-Chloro-6-nitro-3H-quinazolin-4-one
CBNumber:
CB01180189
Molecular Formula:
C8H4ClN3O3
Molecular Weight:
225.59
MDL Number:
MFCD09388771
MOL File:
53449-14-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:05:03
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6-Nitro-7-Chloro-4-HydroxyQuinazoline Properties

Melting point 314-319℃
Boiling point 427.8±55.0 °C(Predicted)
Density 1.79±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility slightly sol. in Dimethylformamide
form powder to crystal
pka -2.49±0.20(Predicted)
color White to Light yellow to Dark green
InChI InChI=1S/C8H4ClN3O3/c9-5-2-6-4(1-7(5)12(14)15)8(13)11-3-10-6/h1-3H,(H,10,11,13)
InChIKey URDYTQYZXZKBQT-UHFFFAOYSA-N
SMILES N1C2=C(C=C([N+]([O-])=O)C(Cl)=C2)C(=O)NC=1
CAS DataBase Reference 53449-14-2
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933599590
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
REACH Registrations Active
NFPA 704
0
1 0

6-Nitro-7-Chloro-4-HydroxyQuinazoline price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 757004 7-Chloro-6-nitro-4(3H)quinazolinone 97% 53449-14-2 5g $39 2023-01-07 Buy
Sigma-Aldrich 757004 7-Chloro-6-nitro-4(3H)quinazolinone 97% 53449-14-2 25g $160 2023-01-07 Buy
TCI Chemical C2332 7-Chloro-6-nitro-4-hydroxyquinazoline >98.0%(T) 53449-14-2 5g $57 2026-04-30 Buy
TCI Chemical C2332 7-Chloro-6-nitro-4-hydroxyquinazoline >98.0%(T) 53449-14-2 25g $192 2026-04-30 Buy
Biosynth DCA44914 7-Chloro-6-nitroquinazolin-4(1H)-one 53449-14-2 0.25g $250 2026-06-04 Buy
Product number Packaging Price Buy
757004 5g $39 Buy
757004 25g $160 Buy
C2332 5g $57 Buy
C2332 25g $192 Buy
DCA44914 0.25g $250 Buy

6-Nitro-7-Chloro-4-HydroxyQuinazoline Chemical Properties, Uses, Production

Chemical Properties

Yellow or light yellow powder

Synthesis

7-CHLORO-4-QUINAZOLINOL

31374-18-2

6-Nitro-7-Chloro-4-HydroxyQuinazoline

53449-14-2

General procedure for the synthesis of 7-chloro-4-hydroxy-6-nitroquinazoline from 7-chloro-4(3H)-quinazolinone: Concentrated sulfuric acid (10 mL) and concentrated nitric acid (5 mL) were added to a 100 mL round-bottomed flask, followed by 7-chloro-4(3H)-quinazolinone (10 g, 55.4 mmol). The reaction mixture was stirred at 0 °C, then slowly heated to 90 °C and stirred continuously at this temperature for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water. The precipitate was collected by filtration, washed well with water and then dried. The crude product was purified by recrystallization from acetic acid to give 7-chloro-6-nitroquinazolin-4(3H)-one (6c) as a light yellow solid (9 g, 72% yield). The melting point of the product was 315-316 °C; 1H NMR (DMSO-d6, ppm): δ 12.79 (broad peak, 1H), 8.67 (single peak, 1H), 8.31 (single peak, 1H), 8.01 (single peak, 1H).

References

[1] Medicinal Chemistry Research, 2013, vol. 22, # 9, p. 4096 - 4109
[2] European Journal of Medicinal Chemistry, 2018, vol. 147, p. 227 - 237
[3] Patent: CN108484574, 2018, A. Location in patent: Paragraph 0133; 0134; 0135
[4] Patent: CN103382182, 2016, B. Location in patent: Paragraph 0272; 0273; 0276; 0277
[5] Patent: WO2008/33747, 2008, A2. Location in patent: Page/Page column 129

6-Nitro-7-Chloro-4-HydroxyQuinazoline Preparation Products And Raw materials

Raw materials

7-Chloro-4-quinazolinol

Preparation Products

CCRIS 2546 N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine 7-Morpholin-4-yl-6-nitroquinazolin-4(3H)-one

6-Nitro-7-Chloro-4-HydroxyQuinazoline Suppliers

Global Suppliers ( 211)
Supplier Tel Email Country ProdList Advantage
Chemipanda Bio-Tech Co., Ltd. +86-571-85224801; 13588483690 chemipanda2010@163.com China 98 62
Jiangxi Hechun Pharmaceutical Technology Co., Ltd. 13033833208 3692193759@qq.com China 72 58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 022-60189726 18812034280 188120342808@163.com China 143 61
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Supplier Advantage
Chemipanda Bio-Tech Co., Ltd. 62
Jiangxi Hechun Pharmaceutical Technology Co., Ltd. 58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 61
J & K SCIENTIFIC LTD. 76
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Jinan Trio PharmaTech Co., Ltd. 62

View Latest Price from 6-Nitro-7-Chloro-4-HydroxyQuinazoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Nitro-7-Chloro-4-HydroxyQuinazoline pictures 2022-02-24 6-Nitro-7-Chloro-4-HydroxyQuinazoline
53449-14-2
 $10.00 1KG 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
7-Chloro-6-nitro-4(1H)-quinazolinone pictures 2021-10-29 7-Chloro-6-nitro-4(1H)-quinazolinone
53449-14-2
 $10.00 1KG ≥99% 10000kg Shijiazhuang Erche Biotechnology Co., Ltd
7-Chloro-6-nitro-4(1H)-quinazolinone pictures 2021-09-07 7-Chloro-6-nitro-4(1H)-quinazolinone
53449-14-2
 $10.00 1KG 99% 20 tons Hebei Zhanyao Biotechnology Co. Ltd

6-Nitro-7-Chloro-4-HydroxyQuinazoline Spectrum

6-Nitro-7-Chloro-4-HydroxyQuinazoline(53449-14-2)1HNMR

53449-14-2 (6-Nitro-7-Chloro-4-HydroxyQuinazoline) Related Search:

2-(Trimethylsilyl)ethoxymethyl chloride 4-Hydroxyquinazoline 7-Chloro-4-quinazolinol 6-Amino-3H-quinazolin-4-one 6-Nitroquinazolin-4(3H)-one
6-Nitro-7-Chloro-4-HydroxyQuinazoline

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6-Nitro-7-Chloro-4-HydroxyQuinazoline 7-CHLORO 6-NITRO QUINAZOLINE 4-OL 7-Chloro-6-nitro-4-hydroxyquinazoline 6-Nitro-7-chloro-3,4-dihydroquinazolin-4-one 7-Chloro-1,4-dihydro-6-nitro-4-oxoquinazoline 7-Chloro-6-nitroquinazolin-4(1H)-one 7-Chloro-6-nitro-4-quinazolinol 7-Chloro-6-nitro-3H-quinazolin-4-one 4(3H)-Quinazolinone, 7-chloro-6-nitro- 7-chloro-6-nitroquinazolin-4-ol 7-Chloro-6-nitro-4(3H)quinazolinone 7-Chloro-6-nitro-4-quinazolinol 7-Chloro-6-nitro-4-quinazolinone 7-chloro -6-nitroquinazoline-4- ketone 7-Chloro-6-nitroquinazolin-4(3H) 6-Nitro-7-Chloro-4-HydroxyQuizoline 6-Nitro-7-Chloro-4-HydroxyQuinazoline(53449-14-2) cas 53449-14-2 6-Nitro-7-Chloro-4-HydroxyQuinazoline 7-Chloro-6-nitro-4(1H)-quinazolinone 7-Chloro-6-nitroquinazolin-4-one 7-chloro-6-nitro-3,4-dihydroquinazolin-4-one 7-Chloro-6-nitroquinazolin-4(1H)-one 95+% 7-Chloro-6-nitro-4-hydroxyquinazoline > 7-Chloro-6-nitro-4-quinazolinone Mefatinib Impurity 13 7-CHLORO-6-NITRO-4(3H)-QUINAZOLINONE,97% 53449-14-2 Building Blocks Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks New Products for Chemical Synthesis Quinazolines