6-Nitroquinazolin-4(3H)-one
- CAS No.
- 6943-17-5
- Chemical Name:
- 6-Nitroquinazolin-4(3H)-one
- Synonyms
- 6-NITROQUINAZOLIN-4-OL;NSC 51669;Afatinib Impurity 102;6-NITRO-4-QUINAZOLONE;6-Nitro-4-quinazolinol;6-NITROQUIZOLIN-4(3H)-ONE;6-NITRO-4(1H)-QUINAZOLINONE;6-NITRO-4(3H)-QUINAZOLINONE;6-Nitro-3H-quinazolin-4-one;6-nitro-1H-quinazolin-4-one
- CBNumber:
- CB1676877
- Molecular Formula:
- C8H5N3O3
- Molecular Weight:
- 191.14
- MDL Number:
- MFCD08460966
- MOL File:
- 6943-17-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 286-287 °C |
|---|---|
| Boiling point | 407.0±47.0 °C(Predicted) |
| Density | 1+-.0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | -1.01±0.20(Predicted) |
| color | Yellow |
| InChI | InChI=1S/C8H5N3O3/c12-8-6-3-5(11(13)14)1-2-7(6)9-4-10-8/h1-4H,(H,9,10,12) |
| InChIKey | MOBNCKURXDGQCB-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C([N+]([O-])=O)C=C2)C(=O)NC=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H315-H302 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| HazardClass | IRRITANT |
6-Nitroquinazolin-4(3H)-one price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-N596450-50MG | 6-Nitro-4-quinazolone | 6943-17-5 | 50mg | $113 | 2026-06-03 | Buy |
| TRC | TRC-N596450-100MG | 6-Nitro-4-quinazolone | 6943-17-5 | 100mg | $168 | 2026-06-03 | Buy |
| AstaTech | AR2756 | 6-NITROQUINAZOLIN-4-OL 95% | 6943-17-5 | 1G | $18 | 2026-04-30 | Buy |
| AstaTech | AR2756 | 6-NITROQUINAZOLIN-4-OL 95% | 6943-17-5 | 5G | $57 | 2026-04-30 | Buy |
| AstaTech | AR2756 | 6-NITROQUINAZOLIN-4-OL 95% | 6943-17-5 | 25G | $187 | 2026-04-30 | Buy |
6-Nitroquinazolin-4(3H)-one Chemical Properties, Uses, Production
Chemical Properties
Yellow Solid
Uses
Intermediate in the preparation of anticancer agents and enzyme inhibitors.
Synthesis
77287-34-4
616-79-5
6943-17-5
1. Preparation of 6-nitro-3H-quinazolin-4-one: 150 g of 2-amino-5-nitrobenzoic acid was added to 200 ml of formamide and stirred until completely dissolved. The reaction mixture was heated to 170°C and maintained at this temperature for 4 hours. After completion of the reaction, the mixture was cooled to 100°C. 500 ml of ice water was slowly added and stirring was continued for 1 hour. Subsequently, the mixture was filtered under reduced pressure and the solid product was collected. The solid was washed with plenty of water to remove residual reactants and by-products. Finally, the resulting solid was dried at 40 °C for 15 h to afford 4-hydroxy-6-nitroquinazoline (140 g, 90% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6, 300 MHz): δ8.77 (d, J = 2.7 Hz, 1H), 8.55 (dd, J = 6.9 Hz, 1H), 8.36 (s, 1H), 7.84 (d, J = 9 Hz, 1H).
References
[1] Patent: WO2006/71017, 2006, A1. Location in patent: Page/Page column 34
[2] Tetrahedron Letters, 2002, vol. 43, # 21, p. 3911 - 3913
[3] Tetrahedron Letters, 2003, vol. 44, # 24, p. 4455 - 4458
[4] Patent: US2005/187231, 2005, A1. Location in patent: Page/Page column 14
[5] Tetrahedron, 2013, vol. 69, # 15, p. 3182 - 3191
6-Nitroquinazolin-4(3H)-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan graphe Pharmaceutical Technology Co., Ltd. | 18995639250 | huangxq@graphe-tech.com | China | 500 | 55 |
| Shanghai Famo Biotechnology Co., Ltd. | 021-36680037 19375184386 | sunshiqi@famobiotech.com | China | 473 | 58 |
| Shaoyuan Technology (Shanghai) Co., Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9985 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
View Latest Price from 6-Nitroquinazolin-4(3H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-03 | 6-NITROQUINAZOLIN-4(3H)-ONE
6943-17-5
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-10 | 6-NITROQUINAZOLIN-4(3H)-ONE
6943-17-5
|
$1.00 | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- 6-NITROQUINAZOLIN-4(3H)-ONE
6943-17-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 6-NITROQUINAZOLIN-4(3H)-ONE
6943-17-5
- $1.00
- 98%
- Career Henan Chemical Co
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