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7-Chloro-4-quinazolinol

7-Chloro-4-quinazolinol Structure
7-Chloro-4-quinazolinol structure
CAS No.
31374-18-2
Chemical Name:
7-Chloro-4-quinazolinol
Synonyms
Compound Fr12428;7-CHLOROQUINAZOLIN-4-OL;7-Chloro-4-quinazolinol;7-Chloroquinazolin-4-one;7-Chloro-4(3H)-quinazolone;7-Chloro-3H-quizolin-4-one;7-CHOROQUINAZOLIN-4(3H)-ONE;7-chloro-1H-quinazolin-4-one;7-Chloroquinazolin-4(3H)-one;7-Chloroquinazolin-4(1H)-one
CBNumber:
CB0470643
Molecular Formula:
C8H5ClN2O
Molecular Weight:
180.59
MDL Number:
MFCD00115130
MOL File:
31374-18-2.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:20
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7-Chloro-4-quinazolinol Properties

Melting point 251-253 °C
Boiling point 331.7±44.0 °C(Predicted)
Density 1.50±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 0.36±0.20(Predicted)
Appearance Off-white to light brown Solid
InChI InChI=1S/C8H5ClN2O/c9-5-1-2-6-7(3-5)10-4-11-8(6)12/h1-4H,(H,10,11,12)
InChIKey PMLONMIODRHERC-UHFFFAOYSA-N
SMILES N1C2=C(C=CC(Cl)=C2)C(=O)NC=1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933998090

7-Chloro-4-quinazolinol price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C3720 7-Chloroquinazolin-4(1H)-one min. 98.0 % 31374-18-2 1G $43 2026-04-30 Buy
TCI Chemical C3720 7-Chloroquinazolin-4(1H)-one min. 98.0 % 31374-18-2 5G $130 2026-04-30 Buy
Apolloscientific OR480818 7-Chloro-3H-quinazolin-4-one 97% 31374-18-2 5g $21 2026-06-04 Buy
Apolloscientific OR480818 7-Chloro-3H-quinazolin-4-one 97% 31374-18-2 25g $64 2026-06-04 Buy
Apolloscientific OR480818 7-Chloro-3H-quinazolin-4-one 97% 31374-18-2 100g $252 2026-06-04 Buy
Product number Packaging Price Buy
C3720 1G $43 Buy
C3720 5G $130 Buy
OR480818 5g $21 Buy
OR480818 25g $64 Buy
OR480818 100g $252 Buy

7-Chloro-4-quinazolinol Chemical Properties, Uses, Production

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1305, 1946 DOI: 10.1021/ja01211a058

Synthesis

Formamidine acetate

3473-63-0

2-Amino-4-chlorobenzoic acid

89-77-0

7-CHLORO-4-QUINAZOLINOL

31374-18-2

The general procedure for the synthesis of 7-chloro-4(3H)-quinazolinone from formamidine acetate and 2-amino-4-chlorobenzoic acid was as follows: 10 g of 2-amino-4-chlorobenzoic acid (BB1) and 8 g of formamidine acetate (1.3 eq.) were added to a 100 ml eggplant flask and mixed thoroughly. The mixture was placed in a microwave reactor and reacted at 60% power for 4 min. After completion of the reaction, it was cooled to room temperature, 30 ml of water was added, stirred and the solid product was collected by filtration. The resulting product was 7-chloro-4(3H)-quinazolinone (BB2) in a yield of 10 g with 95% yield.

References

[1] Patent: CN103570738, 2016, B. Location in patent: Paragraph 0303; 0304; 0306
[2] Patent: CN103382182, 2016, B. Location in patent: Paragraph 0272-0275
[3] Patent: WO2012/88712, 2012, A1. Location in patent: Page/Page column 16
[4] MedChemComm, 2015, vol. 6, # 1, p. 222 - 229

7-Chloro-4-quinazolinol synthesis

3473-63-0
89-77-0
31374-18-2
Synthesis of 7-Chloro-4-quinazolinol from Formamidine acetate and 2-Amino-4-chlorobenzoic acid

7-Chloro-4-quinazolinol Preparation Products And Raw materials

Raw materials

Formamide, acetate (1:1) Benzamide, 4-chloro-2-iodo- formamidine 2-Amino-4-chlorobenzoic acid Methanol
formamide 2-Amino-4-chlorobenzoic acid 7-chloroquinazoline-2,4(1H,3H)-dione 2-Amino-4-chlorobenzonitrile 2-amino-4-chlorobenzamide

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Preparation Products

USP7-IN-1 N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-aminoquinazolin-4-aMine 4,7-Dichloroquinazoline

7-Chloro-4-quinazolinol Suppliers

Global Suppliers ( 178)
Supplier Tel Email Country ProdList Advantage
Yangzhou Siyu Chemical Co.,Ltd. 0514-87325867 sales@siyuchem.com China 370 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Paulshine Chemical Co., Ltd. +86-021-37788663 China 186 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Supplier Advantage
Yangzhou Siyu Chemical Co.,Ltd. 55
Energy Chemical 61
Carbott PharmTech Inc. 56
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Shanghai Paulshine Chemical Co., Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64

View Latest Price from 7-Chloro-4-quinazolinol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-CHLORO-4-QUINAZOLINOL pictures 2024-07-21 7-CHLORO-4-QUINAZOLINOL
31374-18-2
 $1.00 1Kg 98% 20T Shaanxi Dideu Medichem Co. Ltd
7-CHLORO-4-QUINAZOLINOL pictures 2019-07-06 7-CHLORO-4-QUINAZOLINOL
31374-18-2
 $100.00 1KG 98% 200KG Career Henan Chemical Co

7-Chloro-4-quinazolinol Spectrum

7-CHLORO-4-QUINAZOLINOL(31374-18-2)1HNMR

31374-18-2 (7-Chloro-4-quinazolinol) Related Search:

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7-CHLOROQUINAZOLIN-4-OL 7-CHLORO-4(1H)-QUINAZOLINONE 7-CHLORO-4-HYDROXYQUINAZOLINE 7-Chloro-4(3H)-quinazolone 7-Chloroquinazolin-4(3H)-one 7-Chloroquinazolin-4-one 7-chloro-1H-quinazolin-4-one 4(3H)-Quinazolinone, 7-chloro- 7-Chloroquinazolin-4(1H)-one 7-Chloro-4(3H-quinazolin-4-one 7-Chloro-3H-quinazolin-4-one 7-chloro-4(3H)-quinazolinone 7-CHLORO-4-QUINAZOLINOL###31374-18-2 7-Chloro-4-Hydroxyquinazoline(WX636185) 7-Chloro-3H-quizolin-4-one 7-chloro-1,4-dihydroquinazolin-4-one 7-CHOROQUINAZOLIN-4(3H)-ONE Cyclopropanamine,1-ethyl-,hydrochloride(1:5) Benzenesulfonylchloride,9-ethoxy- Compound Fr12428 7-Chloro-4-quinazolinol 31374-18-2 128517-87-2 Alcohols and Derivatives Heterocycles