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ChemicalBook >> CAS DataBase List >>3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester,

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester,

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, Structure
3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, structure
CAS No.
273206-92-1
Chemical Name:
3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester,
Synonyms
tert-butyl (1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate;tert-Butyl rel-(1R,5S,6S)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate;1,1-Dimethylethyl (1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate;exo-6-Amino-3-Boc-3-azabi...;exo-6-Amino-3-Boc-3-azabicyclo[3.1.0]hexane;(1alpha,5alpha,6alpha)-6-Amino-3-Boc-3-azabicyclo[3.1.0]hexane;tert-butyl (exo-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate;(1R,5S,6s)-tert-butyl 6-aMino-3-azabicyclo[3.1.0]hexane-3-carbox;trans-tert-butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate;tert-butyl (1S,5R)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate
CBNumber:
CB01277119
Molecular Formula:
C10H18N2O2
Molecular Weight:
198.26
MDL Number:
MFCD09832898
MOL File:
273206-92-1.mol
MSDS File:
SDS
Last updated:2026-05-27 17:17:52
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3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, Properties

Melting point 45-47°
Boiling point 275℃
Density 1.144
Flash point 120℃
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 8.52±0.20(Predicted)
Appearance Off-white to yellow Solid
InChI InChI=1/C10H18N2O2/c1-10(2,3)14-9(13)12-4-6-7(5-12)8(6)11/h6-8H,4-5,11H2,1-3H3/t6-,7+,8+
InChIKey UWWZMHWHRBGMIT-JIGDXULJNA-N
SMILES N[C@@H]1[C@@]2([H])CN(C(=O)OC(C)(C)C)C[C@@]12[H] |&1:1,2,14,r|

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501
HazardClass  IRRITANT
HS Code  2922390090

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR302706 (1R,5S)-tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate 95% 273206-92-1 100mg $56 2026-06-04 Buy
Apolloscientific OR302706 (1R,5S)-tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate 95% 273206-92-1 250mg $69 2026-06-04 Buy
Apolloscientific OR302706 (1R,5S)-tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate 95% 273206-92-1 1g $82 2026-06-04 Buy
Apolloscientific OR302706 (1R,5S)-tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate 95% 273206-92-1 5g $98 2026-06-04 Buy
Apolloscientific OR302706 (1R,5S)-tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate 95% 273206-92-1 25g $460 2026-06-04 Buy
Product number Packaging Price Buy
OR302706 100mg $56 Buy
OR302706 250mg $69 Buy
OR302706 1g $82 Buy
OR302706 5g $98 Buy
OR302706 25g $460 Buy

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, Chemical Properties, Uses, Production

Uses

(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid 1,1-Dimethylethyl Ester, is an intermediate in the preparation of a novel series of Histone Deacetylase (HDAC) Inhibitors, demonstrating class I selectivity and good oral bioavailability. It can also be used in the synthesis of Alatrofloxacin Mesylate (A511400).

Synthesis

Tert-butyl REL-(1R,5S,6S)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate was prepared by using tert-butyl chloroformate and 3-azabicyclo[3.1.0]hexan-6-amine as starting materials.

Take a dry three-necked reaction flask, one fitted with a calcium chloride desiccator, one fitted with a dropping funnel, and the tetrahydrofuran solution needs to be anhydrous in advance. Weigh the tert-butyl ester formyl chloride dissolved in 180mL of anhydrous tetrahydrofuran solution, start the stirring device. After dissolution, the solution was slowly added to 200 mL of tetrahydrofuran solution under ice-water bath conditions (3-azabicyclo[3.1.0]hexan-6-amine had been dissolved in tetrahydrofuran solution), and a solid precipitated immediately, and the stirring was continued for 4 hr at 35 after the addition, and the progress of the reaction was detected by thin-layer chromatography. When the reaction was completed and the reaction solution was cooled, 400 mL of ice water was added to the reaction to make the product precipitate completely, and a light yellow solid was obtained by filtration. After drying and crystallization with anhydrous ethanol, tert-butyl REL-(1R,5S,6S)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate was obtained.

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, Preparation Products And Raw materials

Raw materials

Preparation Products

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, Suppliers

Global Suppliers ( 111)
Supplier Tel Email Country ProdList Advantage
Chengdu Dorher Pharmaceutical CO.,Ltd 028-64259743 19983537320 wangmin@focuspharm.com China 498 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
skychemical Co.Ltd 021-20958197 20965099 sales@skychemical.com China 1182 57
SpringPharma Tech Co.,Ltd +86-25-68710855, +86-25-68710897 sales@springpharma.net China 1260 62
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
shanghai cooperpharm co.,LTD . +86-021-58975553 sales@cooperpharm.com China 1210 56
Supplier Advantage
Chengdu Dorher Pharmaceutical CO.,Ltd 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Shanghai Hanhong Scientific Co.,Ltd. 64
skychemical Co.Ltd 57
SpringPharma Tech Co.,Ltd 62
T&W GROUP 58
Nanjing Norris-Pharm Technology Co., Ltd 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
shanghai cooperpharm co.,LTD . 56

View Latest Price from 3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, pictures 2019-08-06 3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester,
273206-92-1
 $8.80 1KG 97%-99% 100kg Career Henan Chemical Co

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, Spectrum

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester,(273206-92-1)1HNMR

273206-92-1 (3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester,) Related Search:

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(1α,5α,6α)-6-AMino-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid 1,1-DiMethylethyl Ester exo-6-Amino-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester 3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-amino-, 1,1-dimethylethyl ester, (1alpha,5alpha,6alpha)- rac(1R,5S,6S)-tert-butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate tert-butyl (1S,5R)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate tert-butyl (exo-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate trans-tert-butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate exo-6-Amino-3-Boc-3-azabicyclo[3.1.0]hexane exo-6-Amino-3-Boc-3-azabi... (1R,5S,6s)-tert-butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate (1R,5S,6s)-tert-butyl 6-aMino-3-azabicyclo[3.1.0]hexane-3-carbox 6-AMino-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester Meso-(1R,5S,6s)-tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate (1alpha,5alpha,6alpha)-6-Amino-3-Boc-3-azabicyclo[3.1.0]hexane 3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-amino-, 1,1-dimethylethyl ester, (1α,5α,6α)- rel-(1R,5S,6s)-tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate (+/-)-(1R,5S,6S)-tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate tert-Butyl rel-(1R,5S,?6S)?-?6-?amino-?3-?azabicyclo[3.1.0]?hexane-?3-?carboxylate 273206-92-1 (1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid 1,1-Dimethylethyl Ester 1,1-Dimethylethyl (1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate tert-butyl (1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate tert-Butyl rel-(1R,5S,6S)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate 273206-92-1 73206-92-1 AMINOACID