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GW5074

GW5074 structure

CAS No.: 220904-83-6

Chemical Name:: GW5074

Synonyms: W5074;GW5074;CS-399;GW5074, >=98%;GW-5074;GW 5074;GW5074 USP/EP/BP;GW 5074;GW-5074;GW5074;GW 5074, 10 mM in DMSO;RAF1 KINASE INHIBITOR I;GW5074, c-Raf1 kinase inhibitor

CBNumber:: CB0130215

Molecular Formula:: C15H8Br2INO2

Molecular Weight:: 520.94

MDL Number:: MFCD09971042

MOL File:: 220904-83-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-14 16:49:18

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GW5074 Properties

Boiling point	561.4±50.0 °C(Predicted)
Density	2.248±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: soluble
pka	5.86±0.25(Predicted)
form	solid
color	yellow to orange-brown
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI	InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)
InChIKey	LMXYVLFTZRPNRV-XCVCLJGOSA-N
SMILES	N1C2=C(C=C(I)C=C2)C(=CC2=CC(Br)=C(O)C(Br)=C2)C1=O
CAS DataBase Reference	220904-83-6
FDA UNII	P0LE4QW0S6
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2933790090
Storage Class	11 - Combustible Solids

GW5074 price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	G6416	GW5074 powder	220904-83-6	5mg	$193	2026-04-30	Buy
Sigma-Aldrich	553008	Raf1 Kinase Inhibitor I	220904-83-6	1mg	$175	2026-04-30	Buy
TCI Chemical	G0649	GW-5074 [Optimized for Cell Culture]	220904-83-6	1MG	$57	2026-04-30	Buy
TCI Chemical	G0609	GW-5074	220904-83-6	100MG	$166	2026-04-30	Buy
Cayman Chemical	10010368	GW 5074 ≥98%(mixtureofcisandtrans)	220904-83-6	1mg	$41	2026-04-30	Buy

Product number	Packaging	Price	Buy
G6416	5mg	$193	Buy
553008	1mg	$175	Buy
G0649	1MG	$57	Buy
G0609	100MG	$166	Buy
10010368	1mg	$41	Buy

GW5074 Chemical Properties, Uses, Production

Description

GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.

Uses

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.

Biological Activity

Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC 50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.

Biochem/physiol Actions

GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.

storage

Desiccate at -20°C

References

[1] MING-SHYAN CHANG . Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-κB, but not p38 MAPK, pathways[J]. Cellular signalling, 2005, 17 3: Pages 299-310. DOI:10.1016/j.cellsig.2004.07.008
[2] JIAN HUANG . Fibroblast Growth Factor-2 Suppresses Oridonin-Induced L929 Apoptosis Through Extracellular Signal-Regulated Kinase-Dependent and Phosphatidylinositol 3-Kinase-Independent Pathway[J]. Journal of pharmacological sciences, 2006, 102 3: Pages 305-313. DOI:10.1254/jphs.fpj06004x
[3] KAREN LACKEY. The discovery of potent cRaf1 kinase inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2000, 10 3: Pages 223-226. DOI:10.1016/s0960-894x(99)00668-x
[4] BING-CHANG CHEN. Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells.[J]. Journal of immunology, 2004, 173 8: 5219-5228. DOI:10.4049/jimmunol.173.8.5219

GW5074 Preparation Products And Raw materials

Raw materials

Preparation Products

GW5074 Suppliers

Global Suppliers ( 190)

Supplier	Tel	Email	Country	ProdList	Advantage
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9774	55
Guizhou Yituo Chemical Technology Co., Ltd	18628235590	wuliming@yituochem.cn	China	1247	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Jinan Trio PharmaTech Co., Ltd.	0531-88811783	sales@trio-pharmatech.com	China	1856	62
ChemShuttle, Inc.	0510-83588313-811 18800520310	sales@chemshuttle.com	China	2999	62
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4761	58

Supplier	Advantage
Tianjin Kailiqi Biotechnology Co., Ltd.	55
Guizhou Yituo Chemical Technology Co., Ltd	58
Shanghai Boyle Chemical Co., Ltd.	55
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
VDM Biochemicals	64
Jinan Trio PharmaTech Co., Ltd.	62
ChemShuttle, Inc.	62
BOC Sciences	65
Dalian Meilun Biotech Co., Ltd.	58

View Latest Price from GW5074 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-14	GW 5074 220904-83-6	$36.00-83.00		99.32%	10g	TargetMol Chemicals Inc.
2026-06-30	GW5074 220904-83-6		1KG	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2019-12-24	(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6	$1.00	1KG	Min98% HPLC		Career Henan Chemical Co

GW 5074
220904-83-6
$36.00-83.00
99.32%
TargetMol Chemicals Inc.

GW5074
220904-83-6
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
220904-83-6
$1.00
Min98% HPLC
Career Henan Chemical Co

GW5074 Spectrum

GW5074(220904-83-6)¹HNMR

220904-83-6 (GW5074) Related Search:

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RAF1 KINASE INHIBITOR I (3Z)-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLIDENE]-5-IODO-1H-INDOL-2-ONE 5-IODO-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLENE]-2-INDOLINONE 3-(3,5-DIBROMO-4-HYDROXY-BENZYLIDENE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE 3-(3,5-DIBROMO-4-HYDROXYBENZYLIDINE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE GW5074 2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo- 3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one GW5074, >=98% (Z)-3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one GW-5074;GW 5074 Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem GW 5074;GW-5074;GW5074 CS-399 W5074 GW5074 USP/EP/BP 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-2,3-dihydro-1H-indol-2-one 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one (3E)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one GW5074, c-Raf1 kinase inhibitor GW 5074, 10 mM in DMSO 3-(3,5-dibromo-4-hydroxybenzenemethylene)-5-iodo-1,3-dihydroindole-2-one 220904-83-6 20904-83-6 C15H8Br2INO2 BioChemical Cell Signaling and Neuroscience Cell Biology Kinase/Phosphatase Biology Raf Serine/Threonine Kinase Inhibitors MAPK Inhibitors