ChemicalBook >> CAS DataBase List >>modipafant
modipafant
- CAS No.
- 122956-68-7
- Chemical Name:
- modipafant
- Synonyms
- UK-74505;Modipefant;rac-Modipafant;Modipafant racemate;(Rac) Modipafant,(Rac)Modipafant;ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-{2-methylimidazo[4,5-c]pyridin-1-yl}phenyl)-5-[(pyridin-2-yl)carbamoyl]-1,4-dihydropyridine-3-carboxylate - [AC77674];ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate(WXG02205);4-(2-Chlorophenyl)-1,4-dihydro-6-Methyl-2-[4-(2-Methyl-1H-iMidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylaMino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester;2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chlorophenyl)-5-[(2-pyridinylamino)carbonyl]-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester
- CBNumber:
- CB01310883
- Molecular Formula:
- C34H29ClN6O3
- Molecular Weight:
- 605.09
- MDL Number:
- MFCD00864793
- MOL File:
- 122956-68-7.mol
- MSDS File:
- SDS
Last updated:2026-01-04 19:55:51
| Product description | Number | Pack Size | Price |
| rac-Modipafant | M482800 | 100mg | $9625 |
| rac-Modipafant | 47767 | 25mg | $6250 |
| RAC-MODIPAFANT 95.00% | API0013646 | 10MG | $6479.55 |
| More product size | |||
| Density | 1.34±0.1 g/cm3 (20 ºC 760 Torr) |
|---|---|
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 12.14±0.70(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | 3QK4U86953 |
modipafant price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M482800 | rac-Modipafant | 122956-68-7 | 100mg | $9625 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 47767 | rac-Modipafant | 122956-68-7 | 25mg | $6250 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013646 | RAC-MODIPAFANT 95.00% | 122956-68-7 | 10MG | $6479.55 | 2021-12-16 | Buy |
modipafant Chemical Properties,Uses,Production
Uses
Modipafant is a novel and selective PAF antagonist with potent and prolonged oral activity.
in vivo
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection[3].
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively)[4].
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia[5].
| Animal Model: | 8- to 10-week-old BALB/c mice (DEN-2 strain infected)[3] |
| Dosage: | 10 mg/kg |
| Administration: | P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10 |
| Result: | Decreased by approximately 50% the lethality associated with DEN-2 infection. |
| Animal Model: | Male BALB/C (8- to 10- week-old) wild-type mice[5] |
| Dosage: | 5, 10 and 20 mg/kg |
| Administration: | P.o. |
| Result: | Dose-dependently inhibited the Zymosan -induced articular hyperalgesia. |
modipafant Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 30)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3006 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1603 | 59 |
| AN PharmaTech Co Ltd | 86(21)68097365 | sales@anpharma.net | China | 4891 | 55 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
View Lastest Price from modipafant manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-04 | (Rac)-Modipafant
122956-68-7
|
US $219.00-792.00 / mg | 98.09% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | modipafant
122956-68-7
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- (Rac)-Modipafant
122956-68-7
- US $219.00-792.00 / mg
- 98.09%
- TargetMol Chemicals Inc.
-
- modipafant
122956-68-7
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chlorophenyl)-5-[(2-pyridinylamino)carbonyl]-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester
Modipefant
UK-74505
4-(2-Chlorophenyl)-1,4-dihydro-6-Methyl-2-[4-(2-Methyl-1H-iMidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylaMino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester
rac-Modipafant
ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate(WXG02205)
3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester
Modipafant racemate
(Rac) Modipafant,(Rac)Modipafant
ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-{2-methylimidazo[4,5-c]pyridin-1-yl}phenyl)-5-[(pyridin-2-yl)carbamoyl]-1,4-dihydropyridine-3-carboxylate - [AC77674]
122956-68-7
Amines
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals
