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ChemicalBook >> CAS DataBase List >>5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile

5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile

5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Structure
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile structure
CAS No.
2560576-15-8
Chemical Name:
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile
Synonyms
5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile
CBNumber:
CB013348465
Molecular Formula:
C21H13F7N4O3
Molecular Weight:
502.34
MDL Number:
MOL File:
2560576-15-8.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
Request For Quotation

5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Properties

Density 1.53±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka 9.88±0.10(Predicted)
form Solid
color White to off-white

5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0655591 PYR01 99.86% 2560576-15-8 1mg $379 2026-06-04 Buy
ChemScene CS-0655591 PYR01 99.86% 2560576-15-8 5mg $948 2026-06-04 Buy
ChemScene CS-0655591 PYR01 99.86% 2560576-15-8 10mg $1522 2026-06-04 Buy
ChemScene CS-0655591 PYR01 99.86% 2560576-15-8 25mg $3044 2026-06-04 Buy
ChemScene CS-0655591 PYR01 99.86% 2560576-15-8 50mg $4875 2026-06-04 Buy
Product number Packaging Price Buy
CS-0655591 1mg $379 Buy
CS-0655591 5mg $948 Buy
CS-0655591 10mg $1522 Buy
CS-0655591 25mg $3044 Buy
CS-0655591 50mg $4875 Buy

5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Chemical Properties, Uses, Production

Uses

PYR01 is a non-nucleoside reverse transcriptase inhibitor and a killing activator targeting HIV infected cells. PYR01 has cytokilling and antiviral properties of HIV-1 infection with the IC50 values of 27.5nM and 39.7nM, respectively. PYR01 leads to selective cytotoxicity by promoting HIV-1 Gag-Pol dimerization and HIV-1 protease intracellular activation. PYR01 can be used in the study of HIV[1].

References

[1] Carl J Balibar, et al. Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1. Sci Transl Med. 2023 Feb 22;15(684):eabn2038. DOI:10.1126/scitranslmed.abn2038

5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Zhejiang Huida Biotech Co., Ltd. 0571-89903022 18679456698 zilong@hizyme.com China 7853 58
Guangzhou Ruidi Biotechnology Co., Ltd. 020-82099279 18988941402 sales@ubiochem.com China 10000 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Nantong QuanYi Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Zhejiang Huida Biotech Co., Ltd. 58
Guangzhou Ruidi Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from 5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PYR01 pictures 2026-07-27 PYR01
2560576-15-8
 10g TargetMol Chemicals Inc.
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2560576-15-8 (5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile) Related Search:

5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile Ritonavir PLERIXAFOR Gag-Pol polyprotein, HIV (440a.a, His) P24 protein, HIV-1 (BAH97658, HIS)
Rev Protein, HIV-1 group M subtype C (GST)

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5-(Difluoromethyl)-3-[[1-[(5-fluoro-1,2-dihydro-2-oxo-3-pyridinyl)methyl]-1,6-dihydro-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-5-pyrimidinyl]oxy]-2-methylbenzonitrile 2560576-15-8 C21H13F7N4O3