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ChemicalBook >> CAS DataBase List >>5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine

5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine

5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Structure
5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine structure
CAS No.
2761193-67-1
Chemical Name:
5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine
Synonyms
ATR-IN-29;5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine
CBNumber:
CB013538682
Molecular Formula:
C19H22N8O
Molecular Weight:
378.43
MDL Number:
MOL File:
2761193-67-1.mol
TDS File:
TDS
Last updated:2026-04-21 10:31:43
Request For Quotation

5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Properties

Density 1.48±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka 11.25±0.10(Predicted)

5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Chemical Properties, Uses, Production

Uses

ATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC50 value of 1 nM. ATR-IN-29 shows antiproliferative activity[1].

in vivo

ATR-IN-29 (10 mg/kg; p.o.; once) shows good pharmacokinetic parameters with t1/2 of 1.64 h, Cmax of 9343 ng/mL, AUC0-t of 98507 ng·h/mL, AUC0-inf of 98517 ng·h/mL in CD-1 (ICR) mice[1].

IC 50

ATR: 1 nM (IC50)

References

[1] Sui Xiong Cai, et al. Substituted imidazo[1,5-b]pyridazine compounds as kinase inhibitors and use thereof. WO2022135560A1.

5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Preparation Products And Raw materials

Raw materials

Preparation Products

5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Nantong QuanYi Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ATR-IN-29 pictures 2026-04-20 ATR-IN-29
2761193-67-1
 10g TargetMol Chemicals Inc.

2761193-67-1 (5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine) Related Search:

5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine BAY-1895344 BAY1895344 HCl Imidazo[1,5-b]pyridazine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)- Elimusertib (hydrochloride)
AZD-1390

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5-Methyl-2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazine ATR-IN-29 2761193-67-1