CB 30900
- CAS No.
- 145788-82-5
- Chemical Name:
- CB 30900
- Synonyms
- CB 30900;D-Glutamic acid, N-[4-[[(1,4-dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]-L-γ-glutamyl- (9CI)
- CBNumber:
- CB01390645
- Molecular Formula:
- C31H32FN5O9
- Molecular Weight:
- 637.6122832
- MDL Number:
- MFCD00929666
- MOL File:
- 145788-82-5.mol
CB 30900 Chemical Properties,Uses,Production
Description
CB30900 is a novel, potent thymidylate synthase inhibitor. CB30900 is a TS inhibitor that does not rely on polyglutamation for activity. Greater than 90% TS inhibition was achieved following a 4-hr exposure to each compound at equitoxic doses (up to 100 times the IC50 determine by a 48-hr growth inhibition assay).
Uses
CB30900 is an inhibitor for thymidylate synthase with an IC50 of 0.2 μM. CB30900 exhibits cytotoxicity in W1L2 with an IC50 of 0.13 μM[1][2].
References
[1] Walton MI, et al., Preclinical pharmacology of CB30900, a novel dipeptide inhibitor of thymidylate synthase, in mice. J Pharmacol Exp Ther. 1996 May;277(2):909-16. PMID:8627573
[2] Aherne GW, et al., Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells. Biochem Pharmacol. 1996 May 17;51(10):1293-301 DOI:10.1016/0006-2952(96)00035-4
CB 30900 Preparation Products And Raw materials
Raw materials
Preparation Products
CB 30900 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19965 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 233051 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| BOC Sciences | 65 |
| TargetMol Chemicals Inc. | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 58 |