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Dehydroacetic acid

Dehydroacetic acid Structure
Dehydroacetic acid structure
CAS No.
520-45-6
Chemical Name:
Dehydroacetic acid
Synonyms
DHA;dhaa;3-ACETYL-6-METHYL-2H-PYRAN-2,4(3H)-DIONE;2H-Pyran-2-one, 3-acetyl-4-hydroxy-6-methyl-;Geogard(R) 221;DEHYDRANONE;Biocide 470F;Geogard(R) 361;Geogard(R) 111A;DA,Dehydroacetic
CBNumber:
CB0139753
Molecular Formula:
C8H8O4
Molecular Weight:
168.15
MDL Number:
MFCD00066709
MOL File:
520-45-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 18:53:57
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Dehydroacetic acid Properties

Melting point 111-113 °C (lit.)
Boiling point 270 °C (lit.)
Density 1.1816 (rough estimate)
bulk density 700kg/m3
vapor pressure 0.001 hPa (20 °C)
refractive index 1.4611 (estimate)
Flash point 157°C
storage temp. Store below +30°C.
solubility 2g/l
form Fine Crystalline Powder
pka 5.53±0.40(Predicted)
color Light yellow or cream
PH 4 (2g/l, H2O, 20℃)
Odor almost odorless. slightly bitter-sweet taste.
Water Solubility 500mg/L at 25℃
Merck 14,2865
BRN 6129
Henry's Law Constant 2.9×101 mol/(m3Pa) at 25℃, HSDB (2015)
Stability Stable. Incompatible with oxidizing agents, bases, reducing agents.
Cosmetics Ingredients Functions PRESERVATIVE
Cosmetic Ingredient Review (CIR) Dehydroacetic acid (520-45-6)
InChI 1S/C8H8O4/c1-4-3-6(10)7(5(2)9)8(11)12-4/h3,7H,1-2H3
InChIKey PGRHXDWITVMQBC-UHFFFAOYSA-N
SMILES CC(=O)C1C(=O)OC(C)=CC1=O
LogP 0.78 at 20℃
Substances Added to Food (formerly EAFUS) DEHYDROACETIC ACID
FDA 21 CFR 175.105
CAS DataBase Reference 520-45-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 2KAG279R6R
NIST Chemistry Reference Dehydroacetic Acid(520-45-6)
EPA Substance Registry System 3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione (520-45-6)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-26
WGK Germany  1
RTECS  UP8050000
Autoignition Temperature 336 °C
TSCA  TSCA listed
HS Code  29322980
Storage Class 13 - Non Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Hazardous Substances Data 520-45-6(Hazardous Substances Data)
Toxicity LD50 orally in rats: 1000 mg/kg (Spencer)
REACH Registrations Active
NFPA 704
1
1 0

Dehydroacetic acid price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.22011 Dehydroacetic acid for synthesis 520-45-6 5G $31.7 2026-04-30 Buy
Sigma-Aldrich 8.22011 Dehydroacetic acid for synthesis 520-45-6 250g $53.4 2026-04-30 Buy
Sigma-Aldrich 8.22011 Dehydroacetic acid for synthesis 520-45-6 1kg $165 2026-04-30 Buy
Sigma-Aldrich 30740 Dehydroacetic acid ≥98.0% (T) 520-45-6 100g $52.8 2026-04-30 Buy
Sigma-Aldrich 1166309 Dehydroacetic acid United States Pharmacopeia (USP) Reference Standard 520-45-6 200mg $474 2026-04-30 Buy
Product number Packaging Price Buy
8.22011 5G $31.7 Buy
8.22011 250g $53.4 Buy
8.22011 1kg $165 Buy
30740 100g $52.8 Buy
1166309 200mg $474 Buy

Dehydroacetic acid Chemical Properties,Uses,Production

Description

Dehydroacetic acid is an obsolete fungicide. It is highly soluble in water and is also a volatile substance. Ecotoxicological data is scarce. Dehydroacetic acid is moderately toxic to mammals via the oral route, is a neurotoxin and irritant.

Chemical Properties

Dehydroacetic acid is a white to cream-coloured powder that is only very slightly soluble in water (less than 0.1 %). However, the sodium salt hydrate (CSH7Na04.H20) has a solubility of 33% in water at 25°C, and 48% in propylene glycol. The acid is 22% soluble in acetone, 18% in benzene, and I g dissolves in about 35 ml of ethanol.It is used to reduce pickle bloating, and as a pesticide and preservative for squash and strawberries. Its permissible use level is 65ppm.
Dehydroacetic acid is one of the food additives found in red wine and was determined by ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS).
To assay dehydroacetic acid, add 500 mg to a 250-ml Erlenmeyer flask and dissolve in 75 ml of neutral alcohol. Following the addition of phenolphthalein T.S., titrate with 0.1 N NaOH to a pink end-point that persists for at least 30 s. Each ml of 0.1 N NaOH = 16.82 mg of dehydroacetic acid (National Academy of Sciences, 1963).
Dehydroacetic acid is a synthetic chemical (no plant-based preservatives that meet our efficacy standards currently exist) that is considered to be a low hazard for human health and for the environment.

Uses

Dehydroacetic acid (DHS) is used as stabilizer for cosmetic and pharmaceutical products due to its fungicide and bactericide activity, as additive for PVC-stabilizers and for the syntheses of veterinary medicines. Product Data Sheet

Uses

Geogard(R) 111a preservative is based on dehydroacetic acid (DHA) and therefore are recognized by major cosmetic, toiletry and fragrance regulatory authorities worldwide for use in cosmetic and personal care products.

Uses

Geogard(R) 221 preservative is based on dehydroacetic acid (DHA) and benzyl alcohol, and therefore is recognized by major cosmetic, toiletry and fragrance regulatory authorities worldwide for use in cosmetic and personal care products.

Uses

Geogard(R) 361 preservative is based on six synergistic components, all with wide global regulatory acceptance: dehydroacetic acid (DHA); salicylic acid; benzoic acid; phenoxyethanol; benzyl alcohol; and benzethonium chloride.

Uses

antifungal, antibacterial

Uses

dehydroacetic acid is a preservative with low sensitizing potential. This is a weak acid used as a fungi-and bacteria-destroying agent in cosmetics. The presence of organic matter decreases its effective ness. It is not irritating or allergy causing when applied on the skin.

Uses

Dehydroacetic Acid (DHA) is a preservative that is a crystalline powder with a solubility of less than 0.1 g in 100 g of water at 25°C. It can undergo a variety of chemical reactions which give it utility in many applications. It is used at 0.01–0.5% for microbiological growth inhibition in various foods. It is used for cut or peeled squash, with no more than 65 ppm remaining in or on the prepared squash.

Definition

ChEBI: Dehydroacetic acid is a pyran-2,4-dione substituted at position 3 by an acetyl group and at position 6 by a methyl group. A fungicide and bactericide it is used primarily in processed fruit and vegetables. It has a role as a fungicide, an antibacterial agent and a plasticiser. It is a pyran-2,4-dione and a ketone.

Preparation

1) Dehydroacetic acid is prepared from Ethyl acetoacetate by self-condensation under mildly alkaline conditions (Sodium bicarbonate). 2) by polymerization of Ketene, obtained by thermal decomposition of Acetone).

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 5105, 1984 DOI: 10.1021/jo00200a018

General Description

Dehydroacetic acid is a pyrone derivative, that is typically synthesized by the base-catalyzed dimerization of diketene. It is used as a preservative in pharmaceutical, food and cosmetic products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Flammability and Explosibility

Not classified

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and irritating fumes.

Solubility in organics

soluble in most hydrocarbons, but only about 3% soluble in alcohol and about 1.5% in Propylene glycol. Being an acid, it is soluble in aqueous alkali under formation of alkali salt .

Pesticide Type

Fungicide

Dehydroacetic acid synthesis

64-19-7
71-43-2
98-86-2
520-45-6
93-91-4
Synthesis of Dehydroacetic acid from Acetic acid and Benzene

Dehydroacetic acid Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Acetyl ketene Fatty acid ethyl ester Polymerization inhibitor Toluene
Sodium hydroxide-ethanol solution FISH OIL Triethylamine Sodium ethoxide Benzene
Hydrochloric acid Sodium hydroxide Triethylenediamine Pemoline 4H-1,3-Oxazin-4-one, 2,3-dihydro-6-methyl-2-thioxo-

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Preparation Products

Sodium dehydroacetate Clopidol 4-Hydroxy-6-methyl-2-pyrone 2,6-Dimethyl-4H-pyran-4-one

Dehydroacetic acid Suppliers

Global( 522)Suppliers
Supplier Tel Email Country ProdList Advantage
Nantong Tianxiang Bioengineering Co., Ltd 0513-5666452 15152885778 475035221@qq.com China 1073 58
Shandong Fengtai Biotechnology Co., Ltd. 0531-0531-82066716 15662658391 528732991@qq.com China 1064 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Nantong Tianxiang Bioengineering Co., Ltd 58
Shandong Fengtai Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Capot Chemical Co., Ltd 66

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View Lastest Price from Dehydroacetic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dehydroacetic acid pictures 2026-09-13 Dehydroacetic acid
520-45-6
 0.99 RongNa Biotechnology Co.,Ltd
Dehydroacetic acid pictures 2026-09-10 Dehydroacetic acid
520-45-6
 $100.00 1KG 99% 1000 KG HANGZHOU DINGYAN CHEM CO.,LTD
Dehydroacetic acid pictures 2026-08-12 Dehydroacetic acid
520-45-6
 $335.00 25KG 99% 2000T Baoji Guokang Healthchem Co., Ltd.

Dehydroacetic acid Spectrum

Dehydroacetic acid(520-45-6)MSDehydroacetic acid(520-45-6)1HNMRDehydroacetic acid(520-45-6)13CNMRDehydroacetic acid(520-45-6)IR1Dehydroacetic acid(520-45-6)IR2

520-45-6(Dehydroacetic acid)Related Search:

Bensulfuron methyl Trichloroacetic acid Methylparaben TRIOXSALEN Tetrahydro-4H-pyran-4-one
Folic acid Acetyl coenzyme A sodium salt Hyaluronic acid Ethyl acetate Centchroman
Kresoxim-methyl EC 1.1.1.28 Trifluoroacetic acid Methyl acrylate Acetic acid
Citric acid Chlorophosphonazo III N-Acetyl-L-tyrosine ethyl ester

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3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione. enol form 3-acetyl-6-methyl-2h-pyran-2,4(3h)-dione.enolform 3-acetyl-6-methyl-2h-pyran-2,4(3h)-dioneenolform 3-acetyl-6-methyl-2h-pyran-4(3h)-dione 3-Acetyl-6-Methyldihydropyrandione-2,4 3-Acetyl-6-methylpyrandione-2,4 4(3H)-dione,3-acetyl-6-methyl-2H-Pyran-2 4-Hexenoic acid, 2-acetyl-5-hydroxy-3-oxo-, delta-lactone 4-hexenoicacid,2-acetyl-5-hydroxy-3-oxo,lactone Geogard(R) 111A Benzyl alcohol (and) dehydroacetic acid Geogard(R) 221 Geogard(R) 361 Dehydroacetic acid ,98% Acetylmethylpyrandion Acetylmethylpyronone Dehydroacetoic acid 3-Aceto-6-methyl-2-pyronone Dehydroacetic Acid (200 mg) Dehydroacetic acid, 98% 100GR Dehydroacetic acid, 98% 5GR -Acetyl-6-methyl-pyran-2,4-dione Dehydroacetic acid >=98.0% (T) DA,Dehydroacetic dehydro-aceticaci -Hexenoic acid, 2-acetyl-5-hydroxy-3-oxo-, d-lactone Kyselina dehydroacetova kyselinadehydroacetova Methylacetopyronone 3-Acetyl-6-methyl-2-pyranone Dehydroactic acid(DHA) 3-Acetyl-6-methyl-pyran-2,4-dione DEHYDROACETIC ACID FREE ACID CRYSTALLINE PYRAN-2,4-DIONE,3-ACETYL-6-METHYL 3-Acetyl-6-methyl-2H-pyran-2,4(3H)dion DEHYDRACETSAEURE 3-acetyl-6-methyl-2H-pyran-2,4(3H)-dione dehydracetic acid 2-Acetyl-5-hydroxy-3-oxo-4-hexenoic acid δ-lactone, 3-Acetyl-4-hydroxy-6-methyl-2-pyrone Biocide 470F 3-ACETYL-3,4-DIHYDRO-6-METHYL-2H-PYRAN-2,4-DIONE 3-ACETYL-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE 3-ACETYL-4-HYDROXY-6-METHYL-2-PYRONE 3-ACETYL-6-METHYL-2H-PYRAN-2,4(3H)-DIONE 3-ACETYL-6-METHYL-2H-PYRONE-2,4-(3H)-DIONE 2-ACETYL-5-HYDROXY-3-OXO-4-HEXENOIC ACID DELTA-LACTONE 2-ACETYL-5-HYDROXY-3-OXO-4-HEXENOIC ACID D-LACTONE 2-ACETYL-5-HYDROXY-3-OXO-4-HEXENOIC ACID GAMMA-LACTONE 2-acetyl-5-hydroxy-3-oxo-4-hexenoicacidelta-lactone 2-Acetyl-5-hydroxy-3-oxo-4-hexenoicacid-lactone 2H-Pyran-2,4(3H)-dione, 3-acetyl-6-methyl- 3-acetyl-4-hydroxy-6-methyl-2h-pyran-2-on 3-Acetyl-4-hydroxy-6-methyl-2-pyrone cyclic ketone 3-Acetyl-6-methyl-2,3-dihydropyran-2,4-dione 3-Acetyl-6-methyl-2,4-pyrandione 3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione, ion(1-) DEHYDRACETIC ACID DEHYDRANONE DEHYDROACETIC ACID