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Triethylenediamine

Triethylenediamine Structure
Triethylenediamine structure
CAS No.
280-57-9
Chemical Name:
Triethylenediamine
Synonyms
DABCO;1,4-DIAZABICYCLO[2.2.2]OCTANE;teda;DBACO;TED;BACO;1,4-diazobicyclo[2.2.2]octane;1,4-diazabicyclooctane;Dabco 33LV;Diazabicyclooctane
CBNumber:
CB9164730
Molecular Formula:
C6H12N2
Molecular Weight:
112.17
MDL Number:
MFCD00006689
MOL File:
280-57-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:56:08
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Triethylenediamine Properties

Melting point 156-159 °C(lit.)
Boiling point 174 °C
Density 1.02 g/mL
bulk density 800kg/m3
vapor pressure 2.9 mm Hg ( 50 °C)
refractive index n20/D 1.4634(lit.)
Flash point 198 °F
storage temp. Store below +30°C.
solubility 400g/l
form Hygroscopic Crystals
pka 3.0, 8.7(at 25℃)
color White to pale yellow
Water Solubility 46 g/100 mL (26 ºC)
Sensitive Hygroscopic
Merck 14,9669
BRN 103618
Henry's Law Constant 3.1×103 mol/(m3Pa) at 25℃, Du et al. (2017)
Stability Stable, but very hygroscopic. Incompatible with strong oxidizing agents, strong acids. Highly flammable.
InChI 1S/C6H12N2/c1-2-8-5-3-7(1)4-6-8/h1-6H2
InChIKey IMNIMPAHZVJRPE-UHFFFAOYSA-N
SMILES N12CCN(CC2)CC1
LogP -0.49 at 20℃
CAS DataBase Reference 280-57-9(CAS DataBase Reference)
FDA UNII X8M57R0JS5
NIST Chemistry Reference Triethylenediamine(280-57-9)
EPA Substance Registry System 1,4-Diazabicyclo[2.2.2]octane (280-57-9)
UNSPSC Code 12352100
NACRES NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Corrosion (GHS05)Exclamation Mark (GHS07)
GHS02,GHS05,GHS07
Signal word  Danger
Hazard statements  H228-H302-H315-H318
Precautionary statements  P210-P240-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn,F
Risk Statements  22-36/37/38-52/53-41-36/38-11
Safety Statements  26-60-37/39-3-16-36/37-61
RIDADR  UN 1325 4.1/PG 2
WGK Germany  1
RTECS  HM0354200
F  3
Autoignition Temperature 350 °C
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
HS Code  29335920
Storage Class 4.1B - Flammable solid hazardous materials
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Flam. Sol. 1
Skin Irrit. 2
Hazardous Substances Data 280-57-9(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 700 mg/kg
REACH Registrations Active
Limited Quantities 1.0 Kg (2.2 lbs)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
2
3 1

Triethylenediamine price More Price(84)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.03456 1,4-Diazabicyclo[2.2.2]octane for synthesis 280-57-9 100g $82.8 2026-04-30 Buy
Sigma-Aldrich 8.03456 1,4-Diazabicyclo[2.2.2]octane for synthesis 280-57-9 250g $162 2026-04-30 Buy
Sigma-Aldrich 8.03456 1,4-Diazabicyclo[2.2.2]octane for synthesis 280-57-9 1kg $514 2026-04-30 Buy
Sigma-Aldrich 290734 Dabco? 33-LV 280-57-9 100ml $92 2026-04-30 Buy
Sigma-Aldrich 290734 Dabco? 33-LV 280-57-9 500ml $305 2026-04-30 Buy
Product number Packaging Price Buy
8.03456 100g $82.8 Buy
8.03456 250g $162 Buy
8.03456 1kg $514 Buy
290734 100ml $92 Buy
290734 500ml $305 Buy

Triethylenediamine Chemical Properties, Uses, Production

Chemical Properties

Triethylenediamine also known as DABCO or TEDA, is a highly symmetrical molecule with a cage structure. The colorless extremely hygroscopic crystals is a highly nucleophilic tertiary amine base, which is used as a catalyst and reagent in polymerization and organic synthesis.

Uses

An anti-fade reagent shown to scavenge free-radicals due to flurochrome excitation.

Uses

1,4-Diazabicyclo[2.2.2]octane is used as polyurethane catalyst, Balis-Hillman reaction catalyst complexing ligand and lewis base. It finds use in dye lasers and in mounting samples for fluorescence microscopy and as anti-fade reagent shown to scavenge free radicals due to flurochrome excitation of fluorochromes. Further, it is an oxidation and polymerization catalyst.

Definition

ChEBI: Triethylenediamine is an organic heterobicylic compound that is piperazine with an ethane-1,2-diyl group forming a bridge between N1 and N4. It is typically used as a catalyst in polymerization reactions. It has a role as a catalyst, a reagent and an antioxidant. It is a bridged compound, a tertiary amino compound, a saturated organic heterobicyclic parent and a diamine.

Preparation

Triethylenediamine can be produced from ethylenediamine or ethanolamine, diethanolamine, or diethylenetriamine with a variety of different catalysts.

Reactions

Triethylenediamine reacts virtually quantitatively with bromine to give a 1/1 adduct. With alkyl halides it forms quaternary salts, even in nonpolar solvents. Apart from its highly nucleophilic nature, triethylenediamine exhibits catalytic activity in base-catalyzed reactions.

General Description

Dabco33-LV (Db) is a gelling catalyst and a bidentate ligand that forms a self-assembled monolayer (SAM) on a variety of substrates. It functionalizes the surface and immobilizes the surface atoms.

Hazard

Skin irritant.

Flammability and Explosibility

Flammable

Purification Methods

DABCO crystallises from 95% EtOH, pet ether or MeOH/diethyl ether (1:1). Dry it under vacuum over CaCl2 and BaO. It can be sublimed in vacuo, and readily at room temperature. It has also been purified by removal of water during azeotropic distillation of a *benzene solution. It is then recrystallised twice from anhydrous diethyl ether under argon, and stored under argon [Blackstock et al. J Org Chem 52 1451 1987]. [Beilstein 23/3 V 487.]

Toxics Screening Level

The ITSL for Triethylenediamine is 6 μg/m3 annual average.

Triethylenediamine synthesis

103-76-4
280-57-9
Synthesis of Triethylenediamine from 1-(2-Hydroxyethyl)piperazine

Triethylenediamine Preparation Products And Raw materials

Raw materials

Ethylenediamine Piperazine hexahydrate Diethylenetriamine Chloroethane Polyethylene-polyamines
Triethylenetetramine Tetraethylenepentamine 1-(2-Hydroxyethyl)piperazine Sodium Methoxide

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Preparation Products

Dehydroacetic acid (S)-(-)-2,2'-Bis(di-p-tolylphosphino)-1,1'-binaphthyl Ethyl 2-(bromomethyl)acrylate 3-Fluoropyridine-2-carboxylic acid (R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl
5-Bromopyrimidine-2-carbonitrile 1.1'-Binaphthyl-2.2'-diphemyl phosphine (S)-(-)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl Tribenuron methyl 2-Chloro-3-fluoropyridine-4-carboxylic acid
5-Bromopyrimidine-2-carboxylic acid (R)-(+)-TolBINAP Piperazine (1,4-diazabicyclo[2.2.2]octan-1-ium-1-ylsulfonyl)(tert-butoxycarbonyl)amide 1-(chloromethyl)-4-aza-1-azonia bicyclo[2.2.2]octane chloride

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Triethylenediamine Suppliers

Global Suppliers ( 743)
Supplier Tel Email Country ProdList Advantage
Shandong Mantang Hongxin Material Co. , Ltd. 13065055261 3923611010@qq.com China 881 58
Tianjin Zhongxin Chemtech Co., Ltd. 022-66880623 sales@tjzxchem.com China 612 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 13396369453 18678026865 sdfantai@163.com China 904 58
Weifang Weimeng Chemical Co., Ltd. QQ 1340191485 15105445095 weimengchem@163.com China 482 58
Shandong Zhengxing New Material Co. LTD 15805316389; 15805316389 195615660@qq.com China 626 58
Jinan Chuangshi Chemical Co., LTD 0531-18854143038 18854143038 3686420496@qq.com China 765 58
Tianjin Realet Chemical Technology Co.,Ltd. 022-58788819 13602056505 linlin@realetchem.com China 50 55
Shanghai Yanze Chemical Co., Ltd. 15345144255 19901447308 260924549@qq.com China 9989 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Shandong Mantang Hongxin Material Co. , Ltd. 58
Tianjin Zhongxin Chemtech Co., Ltd. 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
Weifang Weimeng Chemical Co., Ltd. 58
Shandong Zhengxing New Material Co. LTD 58
Jinan Chuangshi Chemical Co., LTD 58
Tianjin Realet Chemical Technology Co.,Ltd. 55
Shanghai Yanze Chemical Co., Ltd. 58
J & K SCIENTIFIC LTD. 76

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View Latest Price from Triethylenediamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Triethylenediamine pictures 2026-09-17 Triethylenediamine
280-57-9
 0.99 RongNa Biotechnology Co.,Ltd
Triethylenediamine pictures 2026-09-17 Triethylenediamine
280-57-9
 $1.00 1KG ≥99% 2000mt/year Jinan Finer Chemical Co., Ltd
Triethylenediamine pictures 2026-06-30 Triethylenediamine
280-57-9
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

Triethylenediamine Spectrum

Triethylenediamine(280-57-9)MSTriethylenediamine(280-57-9)1HNMRTriethylenediamine(280-57-9)13CNMRTriethylenediamine(280-57-9)IR1Triethylenediamine(280-57-9)IR2Triethylenediamine(280-57-9)RamanTriethylenediamine(280-57-9)ESR

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1,4-Ethylenepiperazine Bicyclo(2,2,2)-1,4-diazaoctane o[2.2.2]octane Dabco(rg~TEDA~Triethylenediamine Diazabicyclooctane TRIETHLENE DIAMINE Triethylenediamine (DABCO) 1,4-DIAZABICYCLO(2.2.2)OCTAN 1,4-Diazabicyclo(2.2.2)octane, 97+% 1,4-diazabicyclo[2.2.2]octane solution teda, dabco TRIETHYLENEDIAMINE=1,4-DIAZABICYCLO(2,2,2)OCTANE 1,4-Diazabicyclooctan 1,4-Diazabicyclo2.2.2üoctane 1,4-Diazabicyclo2.2.2üoctane, 98+% DABCO(R), TED, Triethylenediamine DABCO(R) 33-LV N,N'-2-hydroxyethyl piperazine 1,4-Diazabicyclo[2.2.2]octane, 97% 100GR Dabco 33-LV,1,4-Diazabicyclo[2.2.2]octane solution 1,4-Diazabicyclo[2.2.2]octane{DABCO} bicyclo(2.2.2)-1,4-diazaoctane Bicyclo[2.2.2]-1,4-diazaoctane Bicyclo[2.2.2]octane, 1,4-diaza- D 33LV d33lv Dabco crystalline Dabco S-25 dabco33lv dabcocrystal dabcoeg dabcor-8020 dabcos-25 n,n’-endo-ethylenepiperazine N,N'-endo-Ethylenepiperazine TEDA-L33 Tegoamin 33 Texacat TD-33 texacattd100 thancattd33 triethylene-diamine,hexahydrate LUPRAGEN(R) N 201 LUPRAGEN(R) N 202 LUPRAGEN(R) N 203 DABCO(TM) DABCO(TM) 33-LV AURORA 15187 2,2'-Diazabicyclo[2.2.2]octane TRIETHYLENEDIAMINE 1,4-Diazabicyclo[2.2.2]octane, 97% 25GR 1,4-Diazabicyclo[2.2.2]octane, 97% 500GR DABCO Triethylenediamine 1,4-DIAZABICYCLO[2.2.2]OCTANE FOR SYNTHE Sanya ethyl diaMine ANTI-FAM155B(C-TERMINAL) antibody produced in rabbit FAM155B Protein TED TMEM28