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4-Hydroxy-6-methyl-2-pyrone

4-Hydroxy-6-methyl-2-pyrone Structure
4-Hydroxy-6-methyl-2-pyrone structure
CAS No.
675-10-5
Chemical Name:
4-Hydroxy-6-methyl-2-pyrone
Synonyms
4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE;4-Hydroxy-6-methylpyran-2-one;Triacetate lactone;6-METHYL-4-HYDROXY-2-PYRONE;188-190℃;NSC 34625;AURORA KA-5368;riacetatelactone;Hydroxy-6-Methyl-2-;triaceticacidlactone
CBNumber:
CB8767354
Molecular Formula:
C6H6O3
Molecular Weight:
126.11
MDL Number:
MFCD00006641
MOL File:
675-10-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:50:00
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4-Hydroxy-6-methyl-2-pyrone Properties

Melting point 188-190 °C (dec.) (lit.)
Boiling point 174.21°C (rough estimate)
Density 1.2048 (rough estimate)
refractive index 1.4189 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 8.6g/l
form Powder
pka 5.14±0.30(Predicted)
color Off-white to brown
Water Solubility 8.60 g/L (20 ºC)
BRN 113815
InChI InChI=1S/C6H6O3/c1-4-2-5(7)3-6(8)9-4/h2-3,7H,1H3
InChIKey NSYSSMYQPLSPOD-UHFFFAOYSA-N
SMILES C1(=O)OC(C)=CC(O)=C1
CAS DataBase Reference 675-10-5(CAS DataBase Reference)
FDA UNII S1S883S4EE
EPA Substance Registry System 2H-Pyran-2-one, 4-hydroxy-6-methyl- (675-10-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  UQ1000000
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29322980
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Hydroxy-6-methyl-2-pyrone price More Price(79)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H43415 4-Hydroxy-6-methyl-2-pyrone 98% 675-10-5 5g $45.1 2026-04-30 Buy
Sigma-Aldrich H43415 4-Hydroxy-6-methyl-2-pyrone 98% 675-10-5 25g $93.9 2026-04-30 Buy
TCI Chemical H0715 4-Hydroxy-6-methyl-2-pyrone >98.0%(GC) 675-10-5 25g $48 2026-04-30 Buy
TCI Chemical H0715 4-Hydroxy-6-methyl-2-pyrone >98.0%(GC) 675-10-5 500g $405 2026-04-30 Buy
Cayman Chemical 25210 4-Hydroxy-6-methyl-2-pyrone ≥98% 675-10-5 1g $29 2026-04-30 Buy
Product number Packaging Price Buy
H43415 5g $45.1 Buy
H43415 25g $93.9 Buy
H0715 25g $48 Buy
H0715 500g $405 Buy
25210 1g $29 Buy

4-Hydroxy-6-methyl-2-pyrone Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powder

Uses

4-Hydroxy-6-methylpyran-2-one was used in the synthesis of pyrano[3,2-c]pyridones with antiproliferative and apoptosis inducing activities. It was also used in the design of benzisothiazolone human leukocyte elastase inhibitors.

Definition

ChEBI: Triacetate lactone is a member of 2-pyranones. It is a conjugate acid of a triacetate lactone oxoanion.

Synthesis Reference(s)

Synthetic Communications, 20, p. 1931, 1990 DOI: 10.1080/00397919008053123

Synthesis

14.4g (0.1mol) isopropylidene malonate, 35ml dichloromethane and 15ml chlorobenzene were placed in the reaction flask, cooled to <5C under stirring, 10.1g (0.1mol) triethylamine and 10.1g (0.12mol) bis(vinylidene) ketone were added dropwise. After addition, slowly warmed to room temperature, continue to stir for 2 hours. The reaction was washed with cooled dilute hydrochloric acid, dried, filtered and most of the dichloromethane was removed in a rotary evaporator. The residual reactant was heated and refluxed for 2 hours, and yellow crystals were precipitated. The crystals were cooled, filtered and washed with a small amount of ether. After drying, 4-hydroxy-6-methyl-2-pyranone was obtained 10.1g, yield 82%, m.p. 186-189 (literature value 188-189 ).

4-Hydroxy-6-methyl-2-pyrone synthesis

520-45-6
675-10-5
Synthesis of 4-Hydroxy-6-methyl-2-pyrone from Dehydroacetic acid

4-Hydroxy-6-methyl-2-pyrone Preparation Products And Raw materials

Raw materials

6-Acetonyl-4-hydroxy-2-pyrone 1,3-Dioxane-4,6-dione, 5-(1-hydroxy-3-oxobutylidene)-2,2-dimethyl- 5-18-08-00154 (Beilstein Handbook Reference) 2,2-dimethyl-6-(2-oxopropyl)-1,3-dioxin-4-one 4-Hydroxy-5,6-dimethylpyran-2-one
4-Acetyl-3-oxobutanoic Acid S-(hydrogen malonyl)coenzyme A 1-Phenyl-1-trimethylsiloxyethylene Dehydroacetic acid ACETYL COENZYME A TRILITHIUM SALT TRIHYDRATE
Dehydroacetic acid Malonyl chloride

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Preparation Products

4,6-Dimethyl-2-pyrone 2,4-Dichloro-6-methyl-3-nitropyridine 3-Nitro-4-hydroxy-6-methyl-2H-pyran-2-one (5aS,7S)-7-Isopropenyl-3-methyl-6,7,8,9-tetrahydro-5aH-pyrano[4,3-b]chromen-1-one 2-amino-4-(3-methoxyphenyl)-7-methyl-5-oxo-4H,5H-pyrano[3,2-c]pyran-3-carbonitrile

4-Hydroxy-6-methyl-2-pyrone Suppliers

Global Suppliers ( 298)
Supplier Tel Email Country ProdList Advantage
Wuxi Helen Biotechnology Co., Ltd., 0510-85629785 18013409632 sales@reading-chemicals.com China 14072 58
Shanghai QianJin Chemical Technology Co., Ltd 021-20900665 17321230821 2986274987@qq.com China 754 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Supplier Advantage
Wuxi Helen Biotechnology Co., Ltd., 58
Shanghai QianJin Chemical Technology Co., Ltd 55
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60

View Latest Price from 4-Hydroxy-6-methyl-2-pyrone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Hydroxy-6-methyl-2-pyrone pictures 2026-08-20 4-Hydroxy-6-methyl-2-pyrone
675-10-5
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
4-Hydroxy-6-methyl-2-pyrone pictures 2022-02-19 4-Hydroxy-6-methyl-2-pyrone
675-10-5
 1KG 99.3% 100 tons Honest Joy Holdings Limited
4-Hydroxy-6-methyl-2-pyrone pictures 2021-08-13 4-Hydroxy-6-methyl-2-pyrone
675-10-5
 $36.00 1g 99.9% 500000kgs Shijiazhuang tongyang Import and Export Co., LTD

4-Hydroxy-6-methyl-2-pyrone Spectrum

4-Hydroxy-6-methyl-2-pyrone(675-10-5)MS4-Hydroxy-6-methyl-2-pyrone(675-10-5)1HNMR4-Hydroxy-6-methyl-2-pyrone(675-10-5)13CNMR4-Hydroxy-6-methyl-2-pyrone(675-10-5)IR14-Hydroxy-6-methyl-2-pyrone(675-10-5)IR24-Hydroxy-6-methyl-2-pyrone(675-10-5)Raman

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4-hydroxy-6-methyl-2h-pyran-2-on 6-methyl-4-hydroxypyron-(2) triaceticacidlactone Triacetate lactone 6-Methy-4-hydroxy-2-pyrones 4-Hydroxy-6-Methylpyran-2-one, 97+% Hydroxy-6-Methyl-2- NSC 34625 6-methyl-4-oxo-2-pyranolate 6-METHYL-4-HYDROXY-2-PYRANONE AURORA KA-5368 4-Hydroxy-6-methyl-2H-pyran-2-one for synthesis 3,5-DIHYDROXYSORBIC ACID DELTA-LACTONE 3,5-DIHYDROXYSORBIC ACID OMEGA-LACTONE 3,5-DIHYDROXYSORBIC ACID SIGMA-LACTONE 4-HYDROXY-6-METHYL-2-PYRONE 4-hydroxy-6-methylpyran-4-one Hydroxy-6-methyl-2-pyrone,4- 4-Hydroxy-6-Methyl-2-Pyronone 3,5-dihydroxysorbic acid i-lactone 3,5-dihydroxysorbic acid δ-lactone 4-Hydroxy-6-methyl-2-pyrone 98% 188-190℃ 4-Hydroxy-6-methylpyran-2-one 4-Hydroxy-6-methyl-2-pyrone,98% 6-Methyl-4-hydroxy-2-pyrones 4-Hydroxy-6-methyl-2-oxo-2H-pyran, 4-Hydroxy-6-methyl-2-pyrone 5-hydroxy-3-Methyl-2H-pyran-2-one 4-Hydroxy-6-methyl-2-pyrone> 2H-Pyran-2-one, 4-hydroxy-6-methyl- riacetatelactone 4-Hydroxy-6-methyl-2-pyrone ISO 9001：2015 REACH 4-hydroxy-6-methyl-2-pyranone 6-methy-4-hydroxy-2-pyrone 4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE 6-METHYL-4-HYDROXY-2-PYRONE 675-10-5 675-10-56 Heterocyclic Building Blocks Lactones Organic Building Blocks Carbonyl Compounds Building Blocks Pyrans Building Blocks Carbonyl Compounds Chemical Synthesis Lactones Organic Building Blocks API intermediates