CHS-828 nicotinate
- CAS No.
- 1160589-73-0
- Chemical Name:
- CHS-828 nicotinate
- Synonyms
- CHS-828 nicotinate;3-Pyridinecarboxylic acid, mixt. with N′′-[6-(4-chlorophenoxy)hexyl]-N-cyano-N′-4-pyridinylguanidine
- CBNumber:
- CB014133363
- Molecular Formula:
- C19H22ClN5O.C6H5NO2
- Molecular Weight:
- 494.97
- MDL Number:
- MOL File:
- 1160589-73-0.mol
- MSDS File:
- SDS
CHS-828 nicotinate Chemical Properties, Uses, Production
Uses
CHS-828 nicotinate is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 nicotinate (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity[1].
References
[1] Watson M, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol. 2009 Nov;29(21):5872-88. DOI:10.1128/MCB.00112-09
[2] Cerna D, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. J Biol Chem. 2012 Jun 22;287(26):22408-17. DOI:10.1074/jbc.M112.357301
CHS-828 nicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
CHS-828 nicotinate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from CHS-828 nicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | CHS-828 nicotinate
1160589-73-0
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- CHS-828 nicotinate
1160589-73-0
- $1520.00-2500.00
- TargetMol Chemicals Inc.
