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PROTAC SMARCA2 degrader-2

PROTAC SMARCA2 degrader-2 structure

CAS No.: 2892523-74-7

Chemical Name:: PROTAC SMARCA2 degrader-2

Synonyms: PROTAC SMARCA2 degrader-2;2-Pyrrolidinecarboxamide, 1-[(2R)-2-[3-[2-[4-[[7′,8′-dihydro-3′-(2-hydroxyphenyl)spiro[piperidine-4,6′(5′H)-pyrazino[2,3-c]pyridazin]-1-yl]methyl]-1-piperidinyl]ethoxy]-5-isoxazolyl]-3-methyl-1-oxobutyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (2S,4R)-;(2S,4R)-4-hydroxy-1-[(2R)-2-{3-[2-(4-{[3'-(2-hydroxyphenyl)-7',8'-dihydro-5'H-spiro[piperidine-4,6'-pyridazino[3,4-b]pyrazin]-1-yl]methyl}piperidin-1-yl)ethoxy]-1,2-oxazol-5-yl}-3-methylbutanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

CBNumber:: CB014209840

Molecular Formula:: C49H62N10O6S

Molecular Weight:: 919.15

MDL Number:

MOL File:: 2892523-74-7.mol

Last updated:2025-05-19 13:47:24

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PROTAC SMARCA2 degrader-2 Properties

Density	1.380±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	8.492±0.35(predicted)

PROTAC SMARCA2 degrader-2 Chemical Properties, Uses, Production

Uses

PROTAC SMARCA2 degrader-2 is a potent and selective SMARCA2/4 PROTAC degrader with an IC50 of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research[1].

References

[1] Liang Lu, et al. Brm targeting compounds and associated methods of use. Patent WO2023287787A1.

PROTAC SMARCA2 degrader-2 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC SMARCA2 degrader-2 Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1644	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	5985	58

Supplier	Advantage
Jilin Province Woda Biotechnology Co., Ltd.	58
Nantong QuanYi Biotechnology Co., Ltd	58

2892523-74-7 (PROTAC SMARCA2 degrader-2) Related Search:

dTAGV-1 ARV-766 CC-94676 DT2216 Acetamide, N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-

ARV-771

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PROTAC SMARCA2 degrader-2 (2S,4R)-4-hydroxy-1-[(2R)-2-{3-[2-(4-{[3'-(2-hydroxyphenyl)-7',8'-dihydro-5'H-spiro[piperidine-4,6'-pyridazino[3,4-b]pyrazin]-1-yl]methyl}piperidin-1-yl)ethoxy]-1,2-oxazol-5-yl}-3-methylbutanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide 2-Pyrrolidinecarboxamide, 1-[(2R)-2-[3-[2-[4-[[7′,8′-dihydro-3′-(2-hydroxyphenyl)spiro[piperidine-4,6′(5′H)-pyrazino[2,3-c]pyridazin]-1-yl]methyl]-1-piperidinyl]ethoxy]-5-isoxazolyl]-3-methyl-1-oxobutyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (2S,4R)- 2892523-74-7