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mGluR5 antagonist-1

mGluR5 antagonist-1 structure

CAS No.: 2761424-76-2

Chemical Name:: mGluR5 antagonist-1

Synonyms: mGluR5 antagonist-1;7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, N-(4-methoxyphenyl)-7-methyl-4-(2-phenylethynyl)-

CBNumber:: CB014274947

Molecular Formula:: C23H18N4O2

Molecular Weight:: 382.42

MDL Number:

MOL File:: 2761424-76-2.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:24

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mGluR5 antagonist-1 Properties

Boiling point	545.5±50.0 °C(predicted)
Density	1.21±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	12.63±0.70(predicted)
form	Solid
color	Off-white to yellow

mGluR5 antagonist-1 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0900921	mGluR5 antagonist-1 98.80%	2761424-76-2	5mg	$244	2026-06-04	Buy
ChemScene	CS-0900921	mGluR5 antagonist-1 98.80%	2761424-76-2	10mg	$390	2026-06-04	Buy
ChemScene	CS-0900921	mGluR5 antagonist-1 98.80%	2761424-76-2	25mg	$780	2026-06-04	Buy
ChemScene	CS-0900921	mGluR5 antagonist-1 98.80%	2761424-76-2	50mg	$1246	2026-06-04	Buy
ChemScene	CS-0900921	mGluR5 antagonist-1 98.80%	2761424-76-2	100mg	$1993	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0900921	5mg	$244	Buy
CS-0900921	10mg	$390	Buy
CS-0900921	25mg	$780	Buy
CS-0900921	50mg	$1246	Buy
CS-0900921	100mg	$1993	Buy

mGluR5 antagonist-1 Chemical Properties, Uses, Production

Uses

mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect[1].

References

[1] Yonglei Du, et al. Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice. Eur J Med Chem. 2023. DOI:10.1016/j.ejmech.2023.115855

mGluR5 antagonist-1 Preparation Products And Raw materials

Raw materials

Preparation Products

mGluR5 antagonist-1 Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2996	55
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Shanghai Beckham Medical Technology Co., Ltd	55
TargetMol Chemicals Inc.	58

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MMPIP (hydrochloride)

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mGluR5 antagonist-1 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, N-(4-methoxyphenyl)-7-methyl-4-(2-phenylethynyl)- 2761424-76-2