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PROTAC BTK Degrader-6

PROTAC BTK Degrader-6 structure

CAS No.: 2767204-39-5

Chemical Name:: PROTAC BTK Degrader-6

Synonyms: PROTAC BTK Degrader-6;1H-Isoindole-1,3(2H)-dione, 5-[3-[[4-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-oxoethyl]-1-piperazinyl]methyl]-1-azetidinyl]-2-(2,6-dioxo-3-piperidinyl)-

CBNumber:: CB014286560

Molecular Formula:: C45H47N11O6

Molecular Weight:: 837.93

MDL Number:

MOL File:: 2767204-39-5.mol

TDS File:: TDS

Last updated:2026-04-24 14:59:02

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PROTAC BTK Degrader-6 Properties

Density	1.545±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	10.832±0.40(predicted)

PROTAC BTK Degrader-6 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0884486	PROTAC BTK Degrader-6 99.24%	2767204-39-5	1mg	$585	2026-06-04	Buy
ChemScene	CS-0884486	PROTAC BTK Degrader-6 99.24%	2767204-39-5	5mg	$1462	2026-06-04	Buy
ChemScene	CS-0884486	PROTAC BTK Degrader-6 99.24%	2767204-39-5	10mg	$2047	2026-06-04	Buy
ChemScene	CS-0884486	PROTAC BTK Degrader-6 99.24%	2767204-39-5	25mg	$3087	2026-06-04	Buy
Arctom	HY-149391	PROTAC BTK Degrader-6 99.24%	2767204-39-5	1mg	$513	2026-05-26	Buy

Product number	Packaging	Price	Buy
CS-0884486	1mg	$585	Buy
CS-0884486	5mg	$1462	Buy
CS-0884486	10mg	$2047	Buy
CS-0884486	25mg	$3087	Buy
HY-149391	1mg	$513	Buy

PROTAC BTK Degrader-6 Chemical Properties, Uses, Production

Uses

PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC50: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6)[1].

References

[1] Huang J, et al. Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation. Eur J Med Chem. 2023 Jul 18;259:115664. DOI:10.1016/j.ejmech.2023.115664

PROTAC BTK Degrader-6 Preparation Products And Raw materials

Raw materials

Preparation Products

2767204-39-5 (PROTAC BTK Degrader-6) Related Search:

PROTAC BTK Degrader-6 (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one 1H-Isoindole-1,3(2H)-dione, 5-[3-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl][1,3'-biazetidin]-1'-yl]-2-(2,6-dioxo-3-piperidinyl)- GBD-9 Ibrutinib Dimer Impurity

Ibrutinib Impurity 15

1of2

PROTAC BTK Degrader-6 1H-Isoindole-1,3(2H)-dione, 5-[3-[[4-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-oxoethyl]-1-piperazinyl]methyl]-1-azetidinyl]-2-(2,6-dioxo-3-piperidinyl)- 2767204-39-5