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5-Fluoro-1H-pyrrolo[2,3-b]pyridine

5-Fluoro-1H-pyrrolo[2,3-b]pyridine structure

CAS No.: 866319-00-8

Chemical Name:: 5-Fluoro-1H-pyrrolo[2,3-b]pyridine

Synonyms: 5-FLUORO-7-AZAINDOLE;SW-10;SWF-10;EOS-60587;5-Fluor-1H-pyrrolo[2,3-b]pyridin;5-Fluoro-1H-pyrrolo[2,3-b]pyridin;5-Fluoro-1H-pyrrolo[2,3-b]pyridine;5-Fluoro-1H-pyrrolo[2,4-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-;5-Fluoro-7-azaindole (5-Fluoro-1H-pyrrolo[2,3-b]pyridine)

CBNumber:: CB2128702

Molecular Formula:: C7H5FN2

Molecular Weight:: 136.13

MDL Number:: MFCD06659678

MOL File:: 866319-00-8.mol

MSDS File:: SDS

Last updated:2026-09-12 18:50:13

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5-Fluoro-1H-pyrrolo[2,3-b]pyridine Properties

Melting point	112-113°C
Density	1.35
storage temp.	Sealed in dry,Room Temperature
form	powder
pka	13.04±0.40(Predicted)
color	Beige to brown
InChI	1S/C7H5FN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)
InChIKey	BALBNSFYMXBWNM-UHFFFAOYSA-N
SMILES	Fc1cnc2[nH]ccc2c1
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS07
Signal word	Danger
Hazard statements	H302-H318
Precautionary statements	P280-P301+P312+P330-P305+P351+P338+P310
Hazard Codes	Xi,Xn
Risk Statements	22-41
Safety Statements	26-39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1

5-Fluoro-1H-pyrrolo[2,3-b]pyridine price More Price(61)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	ADE000902	5-Fluoro-1H-pyrrolo[2,3-b]pyridine Aldrich	866319-00-8	1g	$909	2026-04-30	Buy
AstaTech	52610	5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE 97%	866319-00-8	1G	$29	2026-04-30	Buy
Apolloscientific	PC200049	5-Fluoro-7-azaindole 97%	866319-00-8	250mg	$21	2026-06-04	Buy
Apolloscientific	PC200049	5-Fluoro-7-azaindole 97%	866319-00-8	1g	$29	2026-06-04	Buy
Apolloscientific	PC200049	5-Fluoro-7-azaindole 97%	866319-00-8	5g	$142	2026-06-04	Buy

Product number	Packaging	Price	Buy
ADE000902	1g	$909	Buy
52610	1G	$29	Buy
PC200049	250mg	$21	Buy
PC200049	1g	$29	Buy
PC200049	5g	$142	Buy

5-Fluoro-1H-pyrrolo[2,3-b]pyridine Chemical Properties, Uses, Production

Chemical Properties

White solid

Uses

5-Fluoro-1H-pyrrolo[2,3-B]pyridine is an important pharmaceutical intermediate. This type of derivative exists in alkaloids such as ASP3627, Mappicine, and Vemurafenib, and can be used as LRRK2 inhibitors, MPS1 inhibitors, JAK1 inhibitors, Met kinase inhibitors, etc.

Synthesis

869557-43-7

75-07-0

866319-00-8

General procedure for the synthesis of 5-fluoro-1H-pyrrolo[2,3-b]pyridine from 2-amino-3-bromo-5-fluoropyridine and acetaldehyde: To a nitrogen-purged 500 mL pressure reactor were added sequentially 3-bromo-5-fluoropyridin-2-ylamine (compound 2a) (20 g, 104.7 mmol, 1.0 equiv.), DABCO (17.6 g, 157.0 mmol, 1.5 equiv.) and tetrabutylammonium bromide (3.38 g, 10.5 mmol, 0.1 equiv.). mmol, 1.5 eq.) and tetrabutylammonium bromide (3.38 g, 10.5 mmol, 0.1 eq.). Subsequently, anhydrous dimethyl sulfoxide (40 mL) and anhydrous ethyl acetate (120 mL) were added to the reactor and the resulting mixture was degassed by nitrogen bubbling for 30 minutes. Next, bis(dibenzylideneacetone)palladium(0) (3.01 g, 5.24 mmol, 0.05 eq.), 10% w/w hexane solution of tri-tert-butylphosphine (21.2 g, 10.47 mmol, 0.1 eq.), and acetaldehyde (5.08 g, 115.2 mmol, 1.1 eq.) were added, and the reaction vessel was sealed. The reaction mixture was stirred at room temperature for 1 hour and then transferred to a 76.5°C oil bath for 5 hours. Upon completion of the reaction, the reaction system was cooled and sampled for HPLC analysis. Upon confirmation of complete conversion of compound 2a to target product 3b (typically 100% conversion after 5 h), the reaction was quenched by adding water (40 mL) to the reaction mixture. The aqueous phase was back-extracted with ethyl acetate (40 mL), and the organic phases were combined and filtered through a diatomaceous earth pad to remove fine solids. The diatomaceous earth pad was washed with ethyl acetate (40 mL), 5% Na2CO3 solution (60 mL) was added to the combined organic phases and stirred under nitrogen protection for 30 minutes. The organic phase was separated, washed with water (60 mL) and concentrated at 80 °C under reduced pressure.

References

[1] Patent: WO2015/73481, 2015, A1. Location in patent: Paragraph 0307

5-Fluoro-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials

Raw materials

2-Amino-3-bromo-5-fluoropyridine 5-fluoro-3-((trimethylsilyl)ethynyl)pyridin-2-amine Acetaldehyde Tetrabutylammomium bromide Tri-tert-butylphosphine

Bis(dibenzylideneacetone)palladium Ethyl acetate Triethylenediamine Dimethyl sulfoxide Hexane

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Preparation Products

5-Fluoro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

5-Fluoro-1H-pyrrolo[2,3-b]pyridine Suppliers

Global Suppliers ( 204)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Yiming Pharmaceutical Technology Co., Ltd.	19850700912; 19850700912	13851286085@163.com	China	979	58
Shenzhen Gre-syn Chemical Technology Co., Ltd.	13226079980	761330897@qq.com	China	1159	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
Shanghai AmasPharm Co., Ltd.	021-54540637 18621091017	sales@amaspharm.com	China	787	62

Supplier	Advantage
Nanjing Yiming Pharmaceutical Technology Co., Ltd.	58
Shenzhen Gre-syn Chemical Technology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Pure Chemistry Scientific Inc.	62
Shanghai Hanhong Scientific Co.,Ltd.	64
China DongFan Chemical Co.,LTD	66
Shanghai AmasPharm Co., Ltd.	62

View Latest Price from 5-Fluoro-1H-pyrrolo[2,3-b]pyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE 866319-00-8		1KG	97.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-04-04	5-Fluoro-1H-pyrrolo[2,3-b]pyridine 866319-00-8		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE 866319-00-8	$500.00	1KG	98%	1ton	Career Henan Chemical Co

5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE
866319-00-8
$0.00
97.0%
Shaanxi Dideu New Materials Co. Ltd

5-Fluoro-1H-pyrrolo[2,3-b]pyridine
866319-00-8
98%
Henan Aochuang Chemical Co.,Ltd.

5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE
866319-00-8
$500.00
98%
Career Henan Chemical Co

5-Fluoro-1H-pyrrolo[2,3-b]pyridine Spectrum

5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE(866319-00-8)¹HNMR

866319-00-8 (5-Fluoro-1H-pyrrolo[2,3-b]pyridine) Related Search:

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1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]- 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine 6-Chloro-5-fluoro-7-azaindole methyl 6‐bromo‐2‐oxo‐2,3‐dihydro‐1h‐indole‐4‐carboxylate Methyl 7-azaindole-6-carboxylate

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5-FLUORO-7-AZAINDOLE 5-Fluoro-7-azaindole (5-Fluoro-1H-pyrrolo[2,3-b]pyridine) 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro- EOS-60587 5-Fluoro-1H-pyrrolo[2,3-b]pyridin SWF-10 SW-10 5-Fluoro-1H-pyrrolo[2,4-b]pyridine 5-Fluor-1H-pyrrolo[2,3-b]pyridin 5-Fluoro-1H-pyrrolo[2,3-b]pyridine 866319-00-8 Fluorine series Heterocycles series CHIRAL CHEMICALS