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2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide

2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide structure

CAS No.: 846023-24-3

Chemical Name:: 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide

Synonyms: SKL780;Bosutinib Impurity 29;N-(2,4-Dichloro-5-methoxyphenyl)-2-cyanoacetamide;2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide;2-Cyano-N-(2,4-Dichloro-5-methoxyphenyl)ethylAmide;AcetaMide,2-cyano-N-(2,4-dichloro-5-Methoxyphenyl)-

CBNumber:: CB01482463

Molecular Formula:: C10H8Cl2N2O2

Molecular Weight:: 259.09

MDL Number:: MFCD10565601

MOL File:: 846023-24-3.mol

Last updated:2026-09-12 18:44:34

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2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide Properties

Melting point	180-181 °C(Solv: ethyl acetate (141-78-6))
Boiling point	462.4±45.0 °C(Predicted)
Density	1.436±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	-1.71±0.10(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C10H8Cl2N2O2/c1-16-9-5-8(6(11)4-7(9)12)14-10(15)2-3-13/h4-5H,2H2,1H3,(H,14,15)
InChIKey	RPWHAQJEZWBZGX-UHFFFAOYSA-N
SMILES	C(NC1=CC(OC)=C(Cl)C=C1Cl)(=O)CC#N
CAS DataBase Reference	846023-24-3
FDA UNII	K3SP4M83RW

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332
Precautionary statements	P280
REACH Registrations	Active

2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Strem Chemicals	06-0011	2',4'-Dichloro-5'-methoxy-2-cyanoacetanilide, min. 94% min.94%	846023-24-3	5g	$30	2026-04-30	Buy
Strem Chemicals	06-0011	2',4'-Dichloro-5'-methoxy-2-cyanoacetanilide, min. 94% min.94%	846023-24-3	25g	$122	2026-04-30	Buy
Synthonix	C53670	2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide 97%	846023-24-3	1g	$60	2026-05-06	Buy
Synthonix	C53670	2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide 97%	846023-24-3	5g	$67	2026-05-06	Buy
Synthonix	C53670	2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide 97%	846023-24-3	25g	$130	2026-05-06	Buy

Product number	Packaging	Price	Buy
06-0011	5g	$30	Buy
06-0011	25g	$122	Buy
C53670	1g	$60	Buy
C53670	5g	$67	Buy
C53670	25g	$130	Buy

2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide Chemical Properties, Uses, Production

Uses

2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide (cas# 846023-24-3) is a useful research chemical.

Chemical Properties

Pale yellow powder

Synthesis

98446-49-2

372-09-8

846023-24-3

Example 4 Synthesis of 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide: 2,4-dichloro-5-methoxyaniline (5.00 g, 26 mmol) was mixed with cyanoacetic acid (2.28 g, 26.8 mmol) at 50 °C. Tetrahydrofuran was added to the mixture until complete dissolution. Subsequently, the solution was heated to reflux and 1,3-diisopropylcarbodiimide (4.2 mL, 26.8 mmol) was added slowly and dropwise. After 30 minutes of reaction, the reaction mixture was cooled to about 15 °C in an ice bath. The solid product formed was collected by filtration and washed with tetrahydrofuran. The filtrate was slowly poured into water and stirred for 30 minutes. The white solid product was collected by filtration again, washed with water and dissolved in 500 mL of ethyl acetate. The resulting solution was dried over anhydrous sodium sulfate and subsequently concentrated under vacuum to afford 5.9 g (88% yield) of the target compound 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide as a white solid with a melting point of 180-181 °C.1H NMR (400 MHz, DMSO-d6) δ 3.84 (s, 3H), 4.02 (s, 2H) 7.58 (s, 1H), 7.66 (s, 1H), 10.00 (s, 1H); mass spectra (electrospray ionization) m/z 257.0, 259.0 ([M-H]-). Elemental analysis (C10H8Cl2N2O2) calculated values: C, 46.36; H, 3.11; N, 10.81. measured values: C, 46.25; H, 3.10; N, 10.85.

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7868 - 7876
[2] Patent: US2005/43537, 2005, A1. Location in patent: Page/Page column 3; 6
[3] Patent: WO2006/47262, 2006, A1. Location in patent: Page/Page column 13-14
[4] Letters in Drug Design and Discovery, 2011, vol. 8, # 1, p. 9 - 13

2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide synthesis

Synthesis of 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide from 2,4-Dichloro-5-methoxyaniline and Cyanoacetic acid

2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide Preparation Products And Raw materials

Raw materials

2,4-Dichloro-5-methoxyaniline Cyanoacetic acid N,N'-Diisopropylcarbodiimide Tetrahydrofuran

Preparation Products

2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide Suppliers

Global Suppliers ( 132)

Supplier	Tel	Email	Country	ProdList	Advantage
Enlian Biomedical (Chongqing) Co., Ltd.	023-023-63134718 13983849334	1501533472@qq.com	China	32	58
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7917	65
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	21-33585366 13311639313	sales@shyrchem.com	China	807	55
Shanghai Famo Bio-chemical Technology Company Ltd.	021-36680027 15821745250	fengqiang@famobiotech.com	China	494	56
SINO High Goal Chemical Technology Co., Ltd.	021-57646680 18306277365	sunkai@chembiobanksh.com	China	2039	55
Taizhou Tongxin Bio-Tech Co., Ltd	0523-86818997 18652728585	sales@allyrise.com	China	2987	60
Zaozhuang Benefit Chemical Co., Ltd.	0531-69958783 15508681609	1948129184@qq.com	China	207	60
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60

Supplier	Advantage
Enlian Biomedical (Chongqing) Co., Ltd.	58
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Adamas Reagent, Ltd.	59
Daicel Chiral Technologies (China)CO.,LTD	65
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	55
Shanghai Famo Bio-chemical Technology Company Ltd.	56
SINO High Goal Chemical Technology Co., Ltd.	55
Taizhou Tongxin Bio-Tech Co., Ltd	60
Zaozhuang Benefit Chemical Co., Ltd.	60
Bide Pharmatech Ltd.	60

View Latest Price from 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE 846023-24-3		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-12-24	2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE 864023-24-3	$1.00	1g	99.99%	200kg	Career Henan Chemical Co
2019-07-06	2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE 846023-24-3	$150.00	1KG	98%	200KG	Career Henan Chemical Co

2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
846023-24-3
98%
Henan Aochuang Chemical Co.,Ltd.

2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
864023-24-3
$1.00
99.99%
Career Henan Chemical Co

2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
846023-24-3
$150.00
98%
Career Henan Chemical Co

2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide Spectrum

2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE(846023-24-3)¹HNMR

846023-24-3 (2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide) Related Search:

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3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy- 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine 4-Methoxy-3-(3-(4-Methylpiperazin-1-yl)propoxy)aniline 4-Chloro-7-hydroxy-6-methoxy-quinoline-3-carbonitrile 4-Chloro-7-(3-chloro-propoxy)-6-methoxy-quinoline-3-carbonitrile

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AcetaMide,2-cyano-N-(2,4-dichloro-5-Methoxyphenyl)- Bosutinib Impurity 29 N-(2,4-Dichloro-5-methoxyphenyl)-2-cyanoacetamide SKL780 2-Cyano-N-(2,4-Dichloro-5-methoxyphenyl)ethylAmide 2-Cyano-N-(2,4-dichloro-5-methoxyphenyl) acetamide 846023-24-3 46023-24-3 864023-24-3 846023-24-2