1-Methylpyrrolidine-2-carboxylic acid
- CAS No.
- 68078-09-1
- Chemical Name:
- 1-Methylpyrrolidine-2-carboxylic acid
- Synonyms
- proline, 1-methyl-;N-methyl DL-proline;1-Methyl-DL-proline;DL-Proline, 1-methyl-;1-methylproline(SALTDATA: HCl);1-Methylpyrrolidine-2-carboxylic acid
- CBNumber:
- CB01483374
- Molecular Formula:
- C6H11NO2
- Molecular Weight:
- 129.16
- MDL Number:
- MFCD01605583
- MOL File:
- 68078-09-1.mol
- MSDS File:
- SDS
| Melting point | 116 °C |
|---|---|
| Boiling point | 227.1±33.0 °C(Predicted) |
| Density | 1.153±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 2.37±0.20(Predicted) |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1 |
| InChIKey | CWLQUGTUXBXTLF-YFKPBYRVSA-N |
| SMILES | C(O)(=O)[C@@H]1CCCN1C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933998090 |
1-Methylpyrrolidine-2-carboxylic acid price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR938983 | 1-Methyl-DL-proline 97% | 68078-09-1 | 250mg | $266 | 2026-06-04 | Buy |
| Apolloscientific | OR938983 | 1-Methyl-DL-proline 97% | 68078-09-1 | 500mg | $410 | 2026-06-04 | Buy |
| Apolloscientific | OR938983 | 1-Methyl-DL-proline 97% | 68078-09-1 | 1g | $613 | 2026-06-04 | Buy |
| Matrix Scientific | 176839 | 1-Methylproline | 68078-09-1 | 250.00mg | $53 | 2026-05-18 | Buy |
| Matrix Scientific | 176839 | 1-Methylproline | 68078-09-1 | 1.00g | $89 | 2026-05-18 | Buy |
1-Methylpyrrolidine-2-carboxylic acid Chemical Properties, Uses, Production
Synthesis
50-00-0
147-85-3
475-11-6
GENERAL METHOD: L-proline (2.0 g, 17.4 mmol) was dissolved in methanol (20 mL), to which 40% aqueous formaldehyde (1.4 mL, 19.1 mmol) was subsequently added. Next, 10% Pd/C catalyst (500 mg) was added to the reaction mixture and the resulting slurry was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the slurry was filtered through a diatomaceous earth pad to remove the catalyst. The diatomaceous earth pad was washed with methanol and the filtrates were combined and concentrated under reduced pressure. The residue was dissolved in a solvent mixture of ethanol/benzene (1:1, 100 mL) and concentrated again under reduced pressure to give a solid product. Finally, the product was purified by recrystallization from methanol/ether mixed solvent to give N-methyl-L-proline (7a) as fine needle-like crystals (2.1 g, 92% yield); melting point 109-111 °C; 1H NMR (D2O, 300 MHz): δ= 3.95-3.90 (1H, m, CH2(CH2)2CHNCH3), 3.24-3.15 (2H , m, CH2(CH2)2CHNCH3), 2.97 (3H, s, CH2(CH2)2CHNCH3), 2.22-2.01 (4H, m, CH2(CH2)2CHNCH3); ESI-MS (m/z): 130.2 [M + H]+ (100).
References
[1] Journal of Organic Chemistry, 2003, vol. 68, # 7, p. 2652 - 2667
[2] Green Chemistry, 2016, vol. 18, # 16, p. 4374 - 4392
[3] European Journal of Organic Chemistry, 2005, # 5, p. 934 - 938
[4] Tetrahedron Letters, 2007, vol. 48, # 43, p. 7680 - 7682
[5] Medicinal Chemistry Research, 2016, vol. 25, # 6, p. 1148 - 1162
1-Methylpyrrolidine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Amber MolTech LLC | 086-010-62176588 | amber@jyamber.com | China | 10150 | 56 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
