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N-Boc-D-proline

N-Boc-D-proline structure

CAS No.: 37784-17-1

Chemical Name:: N-Boc-D-proline

Synonyms: BOC-D-PRO-OH;BOC-D-PRO;N-(TERT-BUTOXYCARBONYL)-D-PROLINE;N-Boc-D-proline;BOC-D-PROLINE;N-Boc-D-proL;BOC-D-PROLINE-OH;BOC-D-PYRD(2)-OH;N-T-BOC-D-PROLINE;BOC-D-Proline,98%

CBNumber:: CB6404051

Molecular Formula:: C10H17NO4

Molecular Weight:: 215.25

MDL Number:: MFCD00063226

MOL File:: 37784-17-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:08:36

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N-Boc-D-proline Properties

Melting point	134-137 °C (lit.)
alpha	60 º (c=2, acetic acid)
Boiling point	355.52°C (rough estimate)
Density	1.1835 (rough estimate)
refractive index	60 ° (C=2, AcOH)
storage temp.	2-8°C
solubility	almost transparency in Acetic acid
pka	4.01±0.20(Predicted)
form	Crystalline Powder or Crystals
color	White to off-white
optical activity	[α]22/D +60°, c = 2 in acetic acid
BRN	479316
Major Application	peptide synthesis
InChI	InChI=1S/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m1/s1
InChIKey	ZQEBQGAAWMOMAI-SSDOTTSWSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC[C@@H]1C(O)=O
CAS DataBase Reference	37784-17-1(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

Safety Statements

24/25

WGK Germany

HS Code

2933 99 80

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

N-Boc-D-proline price More Price(103)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	483818	N-Boc-D-proline 99%	37784-17-1	1g	$33.7	2026-04-30	Buy
Sigma-Aldrich	8.53095	Boc-D-Pro-OH Novabiochem?	37784-17-1	25g	$671	2026-04-30	Buy
Sigma-Aldrich	483818	N-Boc-D-proline 99%	37784-17-1	5g	$140	2026-04-30	Buy
TCI Chemical	B2977	N-(tert-Butoxycarbonyl)-D-proline >98.0%(HPLC)(T)	37784-17-1	5g	$33	2026-04-30	Buy
TCI Chemical	B2977	N-(tert-Butoxycarbonyl)-D-proline >98.0%(HPLC)(T)	37784-17-1	25g	$69	2026-04-30	Buy

Product number	Packaging	Price	Buy
483818	1g	$33.7	Buy
8.53095	25g	$671	Buy
483818	5g	$140	Buy
B2977	5g	$33	Buy
B2977	25g	$69	Buy

N-Boc-D-proline Chemical Properties, Uses, Production

Chemical Properties

White to off-white microcrystalline powder

Uses

tert-Butoxycarbonyl-D-proline is Boc protected D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

344-25-2

37784-17-1

Step-1: Synthesis of N-tert-butoxycarbonyl-(D)-proline: To a stirred solution of D-proline (100 g, 868.58 mmol) in dioxane (400 mL, 8 vol.) was added NaHCO3 (182.4 g, 2.5 equiv.) and water (800 mL, 8 vol.) and the reaction mixture was stirred for about 30 min at room temperature. The reaction mixture was cooled to 0-5 °C, di-tert-butyl dicarbonate (Boc2O) (224.26 g, 1.2 eq.) was slowly added and stirring was continued at 0-5 °C for 1 hour. Subsequently, the reaction mixture was gradually warmed to room temperature and stirred overnight (12-16 h). The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the dioxane solvent was removed by evaporation under reduced pressure. The aqueous layer was acidified to pH 2-3 with 4N HCl solution at 0-5 °C. The aqueous layer was extracted with ethyl acetate (4 x 200 mL), the organic layers were combined, washed with water and dried with anhydrous Na2SO4. The organic layer was concentrated under reduced pressure to give a white solid product. The white solid was added to heptane (200 mL) and stirred at room temperature for 2 hours. The solid was collected by filtration and dried under vacuum at 45-50 °C to give the target compound (wt: 125 g, yield: 90-95%).1H NMR (300 MHz, CDCl3): δ 9.20 (br, 1H), 4.34 (t, 1H), 3.54-3.13 (m, 2H), 2.31-2.25 (m, 1H), 2.09- 1.88 (m, 3H), 1.48-1.42 (b, 9H); MS: [M + Na]+ 238 (100%).

References

[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 8, p. 3455 - 3461
[2] Patent: WO2014/105926, 2014, A1. Location in patent: Paragraph 0264
[3] Synthetic Communications, 2009, vol. 39, # 18, p. 3243 - 3253
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 3, p. 284 - 290
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 20, p. 2691 - 2696

N-Boc-D-proline synthesis

Synthesis of N-Boc-D-proline from Di-tert-butyl dicarbonate and D-Proline

N-Boc-D-proline Preparation Products And Raw materials

Raw materials

D-Proline Acetone Di-tert-butyl dicarbonate Triethylamine Ethyl acetate

Sodium bicarbonate Potassium bisulfate Water 1,4-Dioxane

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Preparation Products

2-Pyrrolidinecarbonitrile,(2R)- (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Boc-D-Pro-OSu Boc-D-beta-homoproline D-1-N-Boc-prolinamide

(R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine

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N-Boc-D-proline Suppliers

Global Suppliers ( 500)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai YuLue Chemical Co., Ltd.	021-60345187 13671753212	lzz841106@aliyun.com	China	10244	55
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
Shanghai Chiral Chemicals Inc.	021-37285021 13472570865	tym7xi@aliyun.com	China	299	64
Organic Bio-Tech (Suzhou) Co.,Ltd	18061997750	info@organic-Biotechnology.com	China	192	58
Shanxi Nuocheng Biotechnology Co., Ltd	17835231871	572710841@qq.com	China	7931	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56

Supplier	Advantage
Shanghai YuLue Chemical Co., Ltd.	55
Shanghai Hobor Chemical Co., Ltd	60
Anhui Dexinjia Biopharm Co., Ltd	58
Shanghai Chiral Chemicals Inc.	64
Organic Bio-Tech (Suzhou) Co.,Ltd	58
Shanxi Nuocheng Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56

View Latest Price from N-Boc-D-proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	Boc-D-Pro-OH 37784-17-1		1kg	98%	10	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-09-16	N-Boc-D-proline 37784-17-1		1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-30	N-Boc-D-proline 37784-17-1	$200.00	1KG	98%	20TONS	Anhui Dexinjia Biopharm Co., Ltd

Boc-D-Pro-OH
37784-17-1
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

N-Boc-D-proline
37784-17-1
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

N-Boc-D-proline
37784-17-1
$200.00
98%
Anhui Dexinjia Biopharm Co., Ltd

N-Boc-D-proline Spectrum

N-Boc-D-proline(37784-17-1)¹HNMR

37784-17-1 (N-Boc-D-proline) Related Search:

L-Proline D-Proline N-Carbobenzyloxyglycine cis-4-Hydroxy-L-proline L-Proline-(4-3H(n))

Di-tert-butyl ether BOC-L-Proline N-Boc-cis-4-Fmoc-Amino-L-proline N-Boc-cis-4-Hydroxy-L-proline methyl ester N-Boc-D-proline

Boc-Hyp-OH Boc-D-Pro-OMe Boc-Oic-OH Boc-Hyp(Bzl)-OH Boc-D-Pro-OSu

Boc-Pro-OSu Boc-Pyr-OH N-Boc-trans-4-Hydroxy-L-proline methyl ester

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(R)-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER T-BUTYLOXYCARBONYL-D-PROLINE N-ALPHA-TERT-BUTYLOXYCARBONYL-D-PROLINE N-ALPHA-T-BUTYLOXYCARBONYL-D-PROLINE N-ALPHA-T-BUTYLOXYCARBONYL-D-PYRROLIDINE-2-CARBOXYLIC ACID N-ALPHA-T-BOC-D-PROLINE BOC-(R)-PYRROLIDINE-5-CARBOXYLIC ACID BOC-D-PROLINE BOC-D-PYRD(2)-OH BOC-D-PROLINE-OH (R)-Boc-pyrrolidine-2-carboxylic acid Boc-D-proline≥ 99% (HPLC) N-Boc-D-proline,99%e.e. (Tert-Butoxy)Carbonyl D-Pro-OH N-Boc-D-proline 97% 1,2-Pyrrolidinedicarboxylicacid, 1-(1,1-dimethylethyl) ester, (2R)- N-tert-Boc-D-Proline N-(TERT-BUTYLOXYCARBONYL)-D-PROLINE N-(TERT-BUTOXYCARBONYL)-D-PROLIN N-T-BOC-D-PROLINE N-BOC-D-PROLINE-OH BOC-D-Proline,98% (R)-1-tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid (2R)-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid Boc-D-Pro-OH Boc-D-Proline N-Boc-D-proline, 98+% BOC-D-PROLINE extrapure N-(tert-Butoxycarbonyl)-D-proline ,99% N-Boc-D-proline ,99% N-Boc-D-proline Boc-D-Pro-OH N-(tert-Butoxycarbonyl)-D-proline > N-Boc-D-proL N-Boc-D-proline USP/EP/BP (2R)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid N-Boc-D-proline N-Boc-D-proline N-Boc-D-proline, 95% BOC-D-PRO BOC-D-PRO-OH N-(TERT-BUTOXYCARBONYL)-D-PROLINE 37784-17-1 377841-17-1 37784-14-1 Peptide Synthesis Specialty Synthesis Amino Acid Derivatives Amino Acids (N-Protected) Biochemistry Boc-Amino Acids Boc-Amino acid series Proline [Pro, P] Boc-Amino Acids and Derivative Pyrrole&Pyrrolidine&Pyrroline Amino Acids Protected Amino Acids