Prostratin, PKC activator

Prostratin, PKC activator Properties

Melting point	216-219℃
Boiling point	550.5±50.0 °C(Predicted)
Density	1.31
storage temp.	-20°C
solubility	Soluble in DMSO at 30mg/ml
form	white powder
pka	11.40±0.70(Predicted)
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey	BOJKFRKNLSCGHY-HXGSDTCMSA-N
SMILES	C[C@@H]1C[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C
FDA UNII	KO94U6DIQ6
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
HS Code	2916200090
Storage Class	11 - Combustible Solids

Prostratin, PKC activator price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P0077	Prostratin ≥98% (HPLC)	60857-08-1	1mg	$141	2026-04-30	Buy
Sigma-Aldrich	P0077	Prostratin ≥98% (HPLC)	60857-08-1	5mg	$566	2026-04-30	Buy
Cayman Chemical	10272	Prostratin ≥98%	60857-08-1	500μg	$75	2026-04-30	Buy
Cayman Chemical	10272	Prostratin ≥98%	60857-08-1	1mg	$120	2026-04-30	Buy
Cayman Chemical	10272	Prostratin ≥98%	60857-08-1	5mg	$479	2026-04-30	Buy

Product number	Packaging	Price	Buy
P0077	1mg	$141	Buy
P0077	5mg	$566	Buy
10272	500μg	$75	Buy
10272	1mg	$120	Buy
10272	5mg	$479	Buy

Prostratin, PKC activator Chemical Properties, Uses, Production

Description

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC₅₀ value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.

Uses

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells . [Cayman Chemical]

Definition

ChEBI: A natural product found in Euphorbia fischeriana.

Biochem/physiol Actions

Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). Prostratin exhibits potent in vitro activity by inducing HIV expression in latently infected cell lines and primary cells, thus antagonizing HIV latency. Activation of PKC and NF-kB has been proposed as the mechanism of action. Prostratin also inhibits HIV entry into target cells by down-regulating CD4 and CXCR4 receptors.

IC 50

PKC: 12.5 nM (Ki); HIV-1

References

[1] A.R. CASHMORE ∗ . The structure of prostratin : a toxic tetracyclic diterpene ester from Pimelea Prostrata[J]. Tetrahedron Letters, 1976, 17 20: Pages 1737-1738. DOI:10.1016/s0040-4039(00)92940-x
[2] GHULAM ABBAS MIANA. Prostratin: An Overview.[J]. Mini reviews in medicinal chemistry, 2015, 15 13: 1122-1130. DOI:10.2174/1389557515666150511154108
[3] XING SHEN . The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents[J]. Cancer letters, 2015, 356 2: Pages 686-696. DOI:10.1016/j.canlet.2014.10.018
[4] ANGÉLIQUE BIANCOTTO. Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue.[J]. Journal of Virology, 2004, 78 19: 10507-10515. DOI:10.1128/jvi.78.19.10507-10515.2004
[5] NOELIA GERIBALDI-DOLDÁN. 12-Deoxyphorbols Promote Adult Neurogenesis by Inducing Neural Progenitor Cell Proliferation via PKC Activation.[J]. International Journal of Neuropsychopharmacology, 2015, 19 1. DOI:10.1093/ijnp/pyv085

Prostratin, PKC activator Preparation Products And Raw materials

Raw materials

Preparation Products

Prostratin, PKC activator Suppliers

Global Suppliers ( 77)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemvon Biotechnology Co., Ltd	021-50790412	info@chemvon.com	China	371	57
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
T&W GROUP	021-61551611 13296011611	contact@trustwe.com	China	9884	58
China Kouting Group Limited	+86 (21) 5811-6473 5811-6475	sales@koutingchina.com	China	494	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29985	65
Hydragon Pharma Ltd	021-50215258	market@hypharma.com	China	320	58
Credit Asia Chemical Co., Ltd.	+86 (21) 61124340		China	9739	58
Chizhou Kailong Import and Export Trade Co., Ltd.		xg01_gj@163.com	China	9413	50

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Chemvon Biotechnology Co., Ltd	57
Nanjing Chemlin Chemical Co., Ltd	64
Chemsky (shanghai) International Co.,Ltd	60
T&W GROUP	58
China Kouting Group Limited	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Hydragon Pharma Ltd	58
Credit Asia Chemical Co., Ltd.	58
Chizhou Kailong Import and Export Trade Co., Ltd.	50

View Latest Price from Prostratin, PKC activator manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-27	Prostratin 60857-08-1	$211.00			10g	TargetMol Chemicals Inc.
2023-08-04	Prostratin 60857-08-1	$10.00	1kg	99%	500t/month	Henan Bao Enluo International TradeCo.，LTD
2020-02-19	Prostratin, PKC activator 60857-08-1	$7.00	1KG	99%	100kg	Career Henan Chemical Co

Prostratin
60857-08-1
$211.00
TargetMol Chemicals Inc.

Prostratin
60857-08-1
$10.00
99%
Henan Bao Enluo International TradeCo.，LTD

Prostratin, PKC activator
60857-08-1
$7.00
99%
Career Henan Chemical Co

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SA 101A Prostatin >99% 12-Deoxyphorbol 13-Acetate, dPAc (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl- 13-O-Acetyl-12-deoxyphorbol (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 13-O-Acetylphorbol NSC 623310 Stillingia Facto CCRIS 6292 12-DEOXYPHORBOL 13-ACETATE (1aR)-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aβ,7bα-dihydroxy-9aα-acetoxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benzo[1,2-e]azulene-5-one (1aR)-9aα-Acetoxy-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα-dihydroxy-3-hydroxymethyl-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one Prostratin, PKC activator 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)- Prostratin, PKC activator USP/EP/BP (1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate Prostratin[P0077] PROSTRATIN 60857-08-1 Activator Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators