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Chloroacetic anhydride

Chloroacetic anhydride Structure
Chloroacetic anhydride structure
CAS No.
541-88-8
Chemical Name:
Chloroacetic anhydride
Synonyms
2-Chloroacetic anhydride;Monochloroacetic anhydride;CHLOROACETIC ACID ANHYDRIDE;MONOCHLOROACETIC ACID ANHYDRIDE;NSC 71207;oroacetic anhydride;chloraceticanhydride;chloroacetylanhydride;Chloracetic anhydride;CHLOROACETIC ANHYDRIDE
CBNumber:
CB4853783
Molecular Formula:
C4H4Cl2O3
Molecular Weight:
170.97
MDL Number:
MFCD00000929
MOL File:
541-88-8.mol
MSDS File:
SDS
Last updated:2026-01-13 11:22:17
Product description Number Pack Size Price
Chloroacetic anhydride 95% 215163 25g $223
Chloroacetic anhydride 95% 215163 100g $363
ChloroacetylAnhydride C327205 25g $115
Chloroacetic anhydride 97% 2126-5-X1 25g $117
Chloroacetic anhydride FC03632 25g $125
More product size
Request For Quotation

Chloroacetic anhydride Properties

Melting point 51 °C
Boiling point 203 °C
Density 1.449
vapor pressure <0.75 mm Hg ( 20 °C)
refractive index 1.4730 (estimate)
Flash point >230 °F
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin
form Crystals, Chunks or Low Melting Mass
color brown
Sensitive Moisture Sensitive
Merck 14,2113
BRN 774533
Stability Moisture Sensitive
InChI 1S/C4H4Cl2O3/c5-1-3(7)9-4(8)2-6/h1-2H2
InChIKey PNVPNXKRAUBJGW-UHFFFAOYSA-N
SMILES ClCC(=O)OC(=O)CCl
CAS DataBase Reference 541-88-8(CAS DataBase Reference)
FDA UNII 8Q7TXH7R5F
EPA Substance Registry System Acetic acid, chloro-, anhydride (541-88-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H314
Precautionary statements  P260-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C,T
Risk Statements  34-36/37-43-25
Safety Statements  26-28-36/37/39-45-27
RIDADR  UN 3261 8/PG 2
WGK Germany  3
F  10-19-21
Hazard Note  Highly Toxic/Corrosive/Lachrymator
TSCA  TSCA listed
HazardClass  8
PackingGroup  II
HS Code  29159000
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 3 Oral
Eye Dam. 1
Skin Corr. 1B
Hazardous Substances Data 541-88-8(Hazardous Substances Data)
Limited Quantities 100ml (liquid) or 0.5 Kg (solid)
Excepted Quantities Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)
NFPA 704
0
0 0
W

Chloroacetic anhydride price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 215163 Chloroacetic anhydride 95% 541-88-8 25g $223 2025-07-31 Buy
Sigma-Aldrich 215163 Chloroacetic anhydride 95% 541-88-8 100g $363 2025-07-31 Buy
TRC C327205 ChloroacetylAnhydride 541-88-8 25g $115 2021-12-16 Buy
SynQuest Laboratories 2126-5-X1 Chloroacetic anhydride 97% 541-88-8 25g $117 2021-12-16 Buy
Biosynth Carbosynth FC03632 Chloroacetic anhydride 541-88-8 25g $125 2021-12-16 Buy
Product number Packaging Price Buy
215163 25g $223 Buy
215163 100g $363 Buy
C327205 25g $115 Buy
2126-5-X1 25g $117 Buy
FC03632 25g $125 Buy

Chloroacetic anhydride Chemical Properties,Uses,Production

Chemical Properties

brownish semi-transparent crystals, chunks or low

Uses

In N-acetylation of amino acids in alkaline solution; preparation of cellulose chloroacetates.

Uses

Chloroacetic anhydride has been used in the synthesis of 3,3-bis(sulfonato)-4,4-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker, D,L-7-azatryptophan, 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2,1:4,5]-2-oxazoline.

Preparation

chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form.

Purification Methods

Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.]

Chloroacetic anhydride synthesis

3926-62-3
79-04-9
541-88-8
Synthesis of Chloroacetic anhydride from Sodium chloroacetate and Chloroacetyl chloride

Chloroacetic anhydride Preparation Products And Raw materials

Raw materials

Acetic acid, 2-chloro-, anhydride with silicic acid (H4SiO4) (4:1) Chloroacetyl chloride

Preparation Products

D-Tryptophan L-Tryptophan 2-Dimethylaminoethyl chloride hydrochloride Acetophenone 2-Chloro-N-(2,6-dimethylphenyl)acetamide
Chloroacetic acid N-(4-BROMOPHENYL)-2-CHLOROACETAMIDE 2-CHLORO-N-(2-METHYLPHENYL)ACETAMIDE 2-Chloro-N-phenylacetamide 4-Phenylphenacyl chloride
2-Chloro-N,N-diethylacetamide 2-PROPIONYLFURAN 3-(2-CHLORO-ACETYL)-3H-BENZOOXAZOL-2-ONE AKOS BBS-00005410

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Chloroacetic anhydride Suppliers

Global( 206)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8753 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5242 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21599 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29833 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 904 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 +8615060885618 sales@amoychem.com China 6369 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Shanghai Arbor Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58

View Lastest Price from Chloroacetic anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chloroacetic anhydride pictures 2026-01-05 Chloroacetic anhydride
541-88-8
 US $10.00 / KG 100KG 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
Chloroacetic Anhydride pictures 2025-05-26 Chloroacetic Anhydride
541-88-8
 US $10.50 / KG 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
Chloroacetic anhydride pictures 2024-04-12 Chloroacetic anhydride
541-88-8
 US $0.00-0.00 / kg 1kg 97% 10000 Mt/Year Shaanxi Haibo Biotechnology Co., Ltd

Chloroacetic anhydride Spectrum

Chloroacetic anhydride(541-88-8)1HNMRChloroacetic anhydride(541-88-8)13CNMRChloroacetic anhydride(541-88-8)IR1Chloroacetic anhydride(541-88-8)Raman

541-88-8(Chloroacetic anhydride)Related Search:

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4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride DICHLOROACETIC ANHYDRIDE
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chloro-aceticacianhydride Chloroacetyl anhydride chloroacetylanhydride chloroethanoicanhydride Monochloroacetic anhydride sym-dichloroaceticanhydride CHLOROACETIC ANHYDRIDE CHLOROACETIC ACID ANHYDRIDE BIS(CHLOROACETIC)ANHYDRIDE MONOCHLOROACETIC ACID ANHYDRIDE 2-Chloroacetic anhydride 2-chloroaceticanhydride Aceticacid,chloro-,anhydride alpha,alpha’-dichloroaceticanhydride Chloracetic anhydride chloraceticanhydride CHLOROACETIC ANHYDRIDE, TECH., APPROX. 9 0% Chloroaceticanhydride,97% (Bischloroacetic acid) anhydride NSC 71207 1,5-Dichloro-3-oxapentan-2,4-dione, 1,5-Dichloro-2,4-dioxo-3-oxapentane Chloroacetic anhydride, tech., 90% Chloroacetic anhydride 97% Chloroacetic anhydride. 90%, tech Monochloroaceitc acid anhydride syMDichloroaceitc anhydride Chloroacetic anhydride, 97% 25GR oroacetic anhydride Acetic acid, 2-chloro-, 1,1'-anhydride 541-88-8 Chloroacetic anhydride 541-88-8 ClCH2CO2O C4H4O3Cl C4H4Cl2O3 Organic Building Blocks Building Blocks Carbonyl Compounds Carboxylic Acid Anhydrides Building Blocks Carbonyl Compounds Carboxylic Acid Anhydrides Chemical Synthesis Organic Building Blocks Pharmaceutical Intermediates