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Chloroacetic anhydride

Chloroacetic anhydride Structure
Chloroacetic anhydride structure
CAS No.
541-88-8
Chemical Name:
Chloroacetic anhydride
Synonyms
2-Chloroacetic anhydride;Monochloroacetic anhydride;CHLOROACETIC ACID ANHYDRIDE;MONOCHLOROACETIC ACID ANHYDRIDE;NSC 71207;oroacetic anhydride;chloraceticanhydride;chloroacetylanhydride;Chloracetic anhydride;CHLOROACETIC ANHYDRIDE
CBNumber:
CB4853783
Molecular Formula:
C4H4Cl2O3
Molecular Weight:
170.97
MDL Number:
MFCD00000929
MOL File:
541-88-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:16:55
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Chloroacetic anhydride Properties

Melting point 51 °C
Boiling point 203 °C
Density 1.449
vapor pressure <0.75 mm Hg ( 20 °C)
refractive index 1.4730 (estimate)
Flash point >230 °F
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin
form Crystals, Chunks or Low Melting Mass
color brown
Sensitive Moisture Sensitive
Merck 14,2113
BRN 774533
Henry's Law Constant 2.2×100 mol/(m3Pa) at 25℃, HSDB (2015)
Stability Moisture Sensitive
InChI 1S/C4H4Cl2O3/c5-1-3(7)9-4(8)2-6/h1-2H2
InChIKey PNVPNXKRAUBJGW-UHFFFAOYSA-N
SMILES ClCC(=O)OC(=O)CCl
CAS DataBase Reference 541-88-8(CAS DataBase Reference)
FDA UNII 8Q7TXH7R5F
EPA Substance Registry System Acetic acid, chloro-, anhydride (541-88-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)Environment (GHS09)
GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H301-H311-H314-H331-H400
Precautionary statements  P264-P270-P280-P260-P261-P271-P273-P301+P310-P330-P302+P352-P312-P361+P364-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P305+P351+P338-P311-P391-P405-P403+P233-P501
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C,T
Risk Statements  34-36/37-43-25
Safety Statements  26-28-36/37/39-45-27
RIDADR  UN 3261 8/PG 2
WGK Germany  3
F  10-19-21
Hazard Note  Highly Toxic/Corrosive/Lachrymator
TSCA  TSCA listed
HazardClass  8
PackingGroup  II
HS Code  29159000
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 3 Oral
Eye Dam. 1
Skin Corr. 1B
Hazardous Substances Data 541-88-8(Hazardous Substances Data)
REACH Registrations Active
Limited Quantities 100ml (liquid) or 0.5 Kg (solid)
Excepted Quantities Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)
NFPA 704
0
0 0
W

Chloroacetic anhydride price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 215163 Chloroacetic anhydride 95% 541-88-8 25g $237 2026-04-30 Buy
Sigma-Aldrich 215163 Chloroacetic anhydride 95% 541-88-8 100g $386 2026-04-30 Buy
TRC TRC-C327205-25G Chloroacetyl Anhydride 541-88-8 25g $159 2026-06-03 Buy
TRC TRC-C327205-1G Chloroacetyl Anhydride 541-88-8 1g $68 2026-06-03 Buy
TRC TRC-C327205-10G Chloroacetyl Anhydride 541-88-8 10g $84 2026-06-03 Buy
Product number Packaging Price Buy
215163 25g $237 Buy
215163 100g $386 Buy
TRC-C327205-25G 25g $159 Buy
TRC-C327205-1G 1g $68 Buy
TRC-C327205-10G 10g $84 Buy

Chloroacetic anhydride Chemical Properties,Uses,Production

Chemical Properties

brownish semi-transparent crystals, chunks or low

Uses

In N-acetylation of amino acids in alkaline solution; preparation of cellulose chloroacetates.

Uses

Chloroacetic anhydride has been used in the synthesis of 3,3-bis(sulfonato)-4,4-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker, D,L-7-azatryptophan, 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2,1:4,5]-2-oxazoline.

Preparation

chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form.

Purification Methods

Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.]

Chloroacetic anhydride synthesis

3926-62-3
79-04-9
541-88-8
Synthesis of Chloroacetic anhydride from Sodium chloroacetate and Chloroacetyl chloride

Chloroacetic anhydride Preparation Products And Raw materials

Raw materials

Acetic acid, 2-chloro-, anhydride with silicic acid (H4SiO4) (4:1) Chloroacetyl chloride

Preparation Products

D-Tryptophan L-Tryptophan 2-Dimethylaminoethyl chloride hydrochloride Acetophenone 2-Chloro-N-(2,6-dimethylphenyl)acetamide
Chloroacetic acid N-(4-Bromophenyl)-2-chloroacetamide 2-Chloro-N-(2-methylphenyl)acetamide 2-Chloro-N-phenylacetamide 4-Phenylphenacyl chloride
2-Chloro-N,N-diethylacetamide 2-Propionylfuran 3-(2-Chloro-acetyl)-3H-benzooxazol-2-one AKOS BBS-00005410

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Chloroacetic anhydride Suppliers

Global( 203)Suppliers
Supplier Tel Email Country ProdList Advantage
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Twochem Co.Ltd. 021-58111628 15800915896 sales@twochem.com China 1782 58
Bayee Biotech (Anqing) Co., Ltd. 0556-5032306 18917961636 wtx@bayeebio.com China 145 61
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Beijing Donghualituo Techonlogy Development Co.,Ltd. 010-88425576 sales@dhltchem.com China 793 59
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Supplier Advantage
Jia Xing Isenchem Co.,Ltd 66
Twochem Co.Ltd. 58
Bayee Biotech (Anqing) Co., Ltd. 61
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Beijing Donghualituo Techonlogy Development Co.,Ltd. 59
Alfa Aesar 84
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57

View Lastest Price from Chloroacetic anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chloroacetic Anhydride pictures 2026-05-28 Chloroacetic Anhydride
541-88-8
 $10.50 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
Chloroacetic anhydride pictures 2026-03-20 Chloroacetic anhydride
541-88-8
 $10.00 100KG 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
Chloroacetic anhydride pictures 2024-04-12 Chloroacetic anhydride
541-88-8
 1kg 97% 10000 Mt/Year Shaanxi Haibo Biotechnology Co., Ltd

Chloroacetic anhydride Spectrum

Chloroacetic anhydride(541-88-8)1HNMRChloroacetic anhydride(541-88-8)13CNMRChloroacetic anhydride(541-88-8)IR1Chloroacetic anhydride(541-88-8)Raman

541-88-8(Chloroacetic anhydride)Related Search:

Dabigatran Etexilate Mesylate 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester Dabigatran etexilate Dabigatran 4-Aminobenzamidine dihydrochloride
N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride Hexyl chloroformate 3-[(3-Amino-4-methylamino-benzoyl)-pyridin-2-yl-amino]-propionic acid ethyl ester N-(4-Cyano-phenyl)-glycine Trichloroacetic anhydride
Chloroacetic anhydride Dichloromaleic anhydride Dichloroacetic anhydride Chlorodifluoroacetic anhydride Chloroacetic acid
Acetic anhydride Acetic acid (chloroacetic)anhydride Chloroacetic anhydride, [2-14C]

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chloro-aceticacianhydride Chloroacetyl anhydride chloroacetylanhydride chloroethanoicanhydride Monochloroacetic anhydride sym-dichloroaceticanhydride CHLOROACETIC ANHYDRIDE CHLOROACETIC ACID ANHYDRIDE BIS(CHLOROACETIC)ANHYDRIDE MONOCHLOROACETIC ACID ANHYDRIDE 2-chloroaceticanhydride Aceticacid,chloro-,anhydride alpha,alpha’-dichloroaceticanhydride Chloracetic anhydride chloraceticanhydride CHLOROACETIC ANHYDRIDE, TECH., APPROX. 9 0% Chloroaceticanhydride,97% (Bischloroacetic acid) anhydride NSC 71207 1,5-Dichloro-3-oxapentan-2,4-dione, 1,5-Dichloro-2,4-dioxo-3-oxapentane Chloroacetic anhydride, tech., 90% Chloroacetic anhydride 97% Chloroacetic anhydride. 90%, tech Monochloroaceitc acid anhydride syMDichloroaceitc anhydride Chloroacetic anhydride, 97% 25GR oroacetic anhydride Acetic acid, 2-chloro-, 1,1'-anhydride 541-88-8 Chloroacetic anhydride 2-Chloroacetic anhydride 541-88-8 541-88-6 ClCH2CO2O C4H4O3Cl C4H4Cl2O3 Organic Building Blocks Building Blocks Carbonyl Compounds Carboxylic Acid Anhydrides Building Blocks Carbonyl Compounds Carboxylic Acid Anhydrides Chemical Synthesis Organic Building Blocks Pharmaceutical Intermediates