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Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Structure
Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate structure
CAS No.
402948-37-2
Chemical Name:
Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate
Synonyms
CHIR161527;Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate;Ethyl 2-[6-(4-Methyl-1-piperazinyl)-2-benzimidazolyl]acetate;ETHYL 2-[5-(4-METHYLPIPERAZINYL)BENZO[D]IMIDAZOL-2-YL]ACETATE;Ethyl [6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]acetate;ethyl 2-(5-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate;ethyl 2-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate;1H-Benzimidazole-2-acetic acid, 6-(4-methyl-1-piperazinyl)-, ethyl ester;6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-acetic acid ethyl ester
CBNumber:
CB01512663
Molecular Formula:
C16H22N4O2
Molecular Weight:
302.37
MDL Number:
MOL File:
402948-37-2.mol
MSDS File:
SDS
Last updated:2026-05-27 17:22:54
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Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Properties

Boiling point 516.4±50.0 °C(Predicted)
Density 1.220±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 12.47±0.10(Predicted)
Appearance White to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Environment (GHS09)
GHS09
Signal word  Warning
Hazard statements  H411

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0008237 Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate ≥98% 402948-37-2 100mg $17 2026-06-04 Buy
ChemScene CS-0008237 Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate ≥98% 402948-37-2 250mg $39 2026-06-04 Buy
ChemScene CS-0008237 Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate ≥98% 402948-37-2 1g $90 2026-06-04 Buy
ChemScene CS-0008237 Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate ≥98% 402948-37-2 5g $360 2026-06-04 Buy
Matrix Scientific 293266 Ethyl 2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate 402948-37-2 250.00mg $50 2026-05-19 Buy
Product number Packaging Price Buy
CS-0008237 100mg $17 Buy
CS-0008237 250mg $39 Buy
CS-0008237 1g $90 Buy
CS-0008237 5g $360 Buy
293266 250.00mg $50 Buy

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Chemical Properties, Uses, Production

Synthesis

ethyl 3-ethoxy-3-iminopropionate

27317-59-5

5-(4-Methylpiperazin-1-yl)-2-nitroaniline

23491-48-7

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate

402948-37-2

General procedure for the synthesis of ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate from ethyl 3-ethoxy-3-iminopropionate and 5-(4-methylpiperazinyl)-2-nitroaniline: 43 mmol of 5-(4-methylpiperazin-1-yl)-2-nitroaniline (compound b) was dissolved in 150 mL of anhydrous ethanol, and then loaded after sufficient dissolution into the first raw material storage tank 1; in the second raw material storage tank 2, 20 mL of 3.6% by weight HCl was dissolved in 150 mL of anhydrous ethanol; 65 mmol of β-ethoxy-β-imino-propionic acid ethyl ester hydrochloride (Compound c) was dissolved in 150 mL of ethanol, and was loaded into the third raw material storage tank 3 after being fully dissolved. At this time, the molar ratio of 5-(4-methylpiperazin-1-yl)-2-nitroaniline to β-ethoxy-β-imino-propionic acid ethyl ester hydrochloride was 1:1.5. The solutions in the first raw material storage tank 1 and the second raw material storage tank 2 were simultaneously pumped into the reaction device, and passed through the first microstructured mixer 4 into the first microstructured reactor (Reactor 1) having an inner diameter of 0.5 mm and a volume of 50 mL Perform the reaction. The microreactor parameters were set: a continuous flow rate of 1.4 mL/min in the first step, a reaction temperature of 80°C, and a residence time of 8 min, and the reaction mainly produced the intermediate 4-(4-methylpiperazin-1-yl)isophthalamide. Subsequently, the solution in the third raw material storage tank 3 and the reaction solution obtained in the reactor 1 were simultaneously pumped into the second microstructure mixer 5, and entered into the second microstructure reactor (reactor 2) with an inner diameter of 0.5 mm and a volume of 50 ml to carry out the mixing reaction. The microreactor parameters were set: continuous flow rate of 3 mL/min for the second step, reaction temperature of 80°C, and residence time of 20 min. After completion of the reaction, the reaction solution was concentrated to obtain an oily substance, which was solubilized with 15 mL of water, extracted several times with CH2Cl2, the organic phases were combined, and the solvent was evaporated to obtain the orange-colored oily substance, i.e., compound d, with a yield of 91%.

References

[1] Patent: CN108610293, 2018, A. Location in patent: Paragraph 0032; 0039-0044; 0048; 0050; 0052; 0054; 0056

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Preparation Products And Raw materials

Raw materials

Ethyl 3-ethoxy-3-iminopropionate hydrochloride ethyl 3-ethoxy-3-iminopropionate 5-(4-Methylpiperazin-1-yl)-2-nitroaniline 4-(4-Methylpiperazino)-1,2-benzenediamine Ethanol
Hydrochloric acid

1of2

Preparation Products

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Suppliers

Global Suppliers ( 40)
Supplier Tel Email Country ProdList Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Taizhou Yikang Chemical Co., Ltd. 0576-88501337 18057652630 sales@yikangchemicals.com China 272 58
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
ShangHai Angti Biotechnology Co., Ltd. 13764913901 info@angtibio.com China 4975 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9787 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-58859352 13913916777 dt3@aikonchem.com China 15490 58
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13774476675 sales@fdc-chemical.com China 9998 58
Shanghai Benso Pharmaceutical Technology Co., Ltd. 15088289376;13917786310 248775804@qq.com China 4916 58
Supplier Advantage
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Guangzhou Isun Pharmaceutical Co., Ltd 55
Taizhou Yikang Chemical Co., Ltd. 58
BOC Sciences 65
ShangHai Angti Biotechnology Co., Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Amadis Chemical Company Limited 58
Aikon International Limited 58
SHANGHAI FDC-CHEMICAL CO.,LTD 58
Shanghai Benso Pharmaceutical Technology Co., Ltd. 58

View Latest Price from Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate pictures 2024-11-26 Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
402948-37-2
 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Spectrum

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate(402948-37-2)1HNMR

402948-37-2 (Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate) Related Search:

[5-(4-Methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-acetic acid ethyl ester (1H-Benzoimidazol-2-yl)-acetic acid ethyl ester 1H-Benzimidazole-2-aceticacid,methylester(9CI) Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate 1H-Benzimidazole,2-(2-ethoxyethyl)-(9CI)
ethyl 2-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate ethyl 2-(5-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate CHIR161527 ETHYL 2-[5-(4-METHYLPIPERAZINYL)BENZO[D]IMIDAZOL-2-YL]ACETATE Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Ethyl [6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]acetate 6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-acetic acid ethyl ester 1H-Benzimidazole-2-acetic acid, 6-(4-methyl-1-piperazinyl)-, ethyl ester Ethyl 2-[6-(4-Methyl-1-piperazinyl)-2-benzimidazolyl]acetate 402948-37-2 API intermediates