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5-(4-Methylpiperazin-1-yl)-2-nitroaniline

5-(4-Methylpiperazin-1-yl)-2-nitroaniline structure

CAS No.: 23491-48-7

Chemical Name:: 5-(4-Methylpiperazin-1-yl)-2-nitroaniline

Synonyms: SIRT6-IN-6;BUTTPARK 17\04-69;5-(4-Methylpiperazino)-2-Nitro;5-(4-METHYLPIPERAZINO)-2-NITROANILINE;5-(4-methylpiperazine) -2-nitroaniline;5-(4-Methyl-1-piperazinyl)-2-nitroaniline;5-(4-METHYL-PIPERAZIN-1-YL)-2-NITROANILINE;5-(4-Methylpiperazin-1-yl)-2-nitroaniline-7;1-(3-Amino-4-nitrophenyl)-4-methylpiperazine;5-(4-METHYLPIPERAZIN-1-YL)-2-NITROPHENYLAMINE

CBNumber:: CB4109303

Molecular Formula:: C11H16N4O2

Molecular Weight:: 236.27

MDL Number:: MFCD00545964

MOL File:: 23491-48-7.mol

MSDS File:: SDS

Last updated:2026-05-28 01:18:02

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5-(4-Methylpiperazin-1-yl)-2-nitroaniline Properties

Melting point	152-155°C
Boiling point	444.2±45.0 °C(Predicted)
Density	1.264±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	7.35±0.42(Predicted)
Appearance	Light yellow to yellow Solid
InChI	InChI=1S/C11H16N4O2/c1-13-4-6-14(7-5-13)9-2-3-11(15(16)17)10(12)8-9/h2-3,8H,4-7,12H2,1H3
InChIKey	MWLBMGPQZJDFKZ-UHFFFAOYSA-N
SMILES	C1(N)=CC(N2CCN(C)CC2)=CC=C1[N+]([O-])=O
CAS DataBase Reference	23491-48-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H335-H302+H312+H332-H315
Precautionary statements	P301+P312-P302+P352-P305+P351+P338
Hazard Codes	Xi
Safety Statements	24/25
HazardClass	IRRITANT
HS Code	29335990

5-(4-Methylpiperazin-1-yl)-2-nitroaniline price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	CL1614	5-(4-METHYLPIPERAZINO)-2-NITROANILINE 97%	23491-48-7	1G	$24	2026-04-30	Buy
AstaTech	CL1614	5-(4-METHYLPIPERAZINO)-2-NITROANILINE 97%	23491-48-7	5G	$73	2026-04-30	Buy
AstaTech	CL1614	5-(4-METHYLPIPERAZINO)-2-NITROANILINE 97%	23491-48-7	25G	$249	2026-04-30	Buy
Activate Scientific	AS30416	5-(4-Methylpiperazin-1-yl)-2-nitrophenylamine 98%	23491-48-7	1g	$42	2026-06-04	Buy
Activate Scientific	AS30416	5-(4-Methylpiperazin-1-yl)-2-nitrophenylamine 98%	23491-48-7	5g	$141	2026-06-04	Buy

Product number	Packaging	Price	Buy
CL1614	1G	$24	Buy
CL1614	5G	$73	Buy
CL1614	25G	$249	Buy
AS30416	1g	$42	Buy
AS30416	5g	$141	Buy

5-(4-Methylpiperazin-1-yl)-2-nitroaniline Chemical Properties, Uses, Production

Description

5-(4-Methylpiperazin-1-yl)-2-nitroaniline (MPNA) is a nitrogen-containing compound that is widely used in scientific research and laboratory experiments. It is a derivative of piperazine, which is a cyclic compound consisting of two piperazine rings joined by a single nitrogen atom. MPNA is a colorless, odorless solid that is soluble in water and organic solvents, making it an ideal compound for a variety of applications.

Chemical Properties

Solid

Uses

5-(4-Methylpiperazin-1-yl)-2-nitroaniline and its derivatives are used as inhibitors of SIRT6 for the treatment of diabetes.

Synthesis

109-01-3

2369-11-1

5-(4-Methylpiperazin-1-yl)-2-nitroaniline

23491-48-7

5-Fluoro-2-nitroaniline (1 g), N-methylpiperazine (0.752 ml) and triethylamine (TEA, 1.86 ml) were mixed in N-methylpyrrolidone (NMP, 1.5 ml). The reaction mixture was placed in a microwave reactor and the reaction was heated at 100°C for 20 hours. After completion of the reaction, it was cooled to room temperature, diluted with deionized water (50 ml), stirred for 20 min and filtered. The resulting yellow solid was washed with deionized water and subsequently dried under high vacuum to give the target product 5-(4-methylpiperazine)-2-nitroaniline (1.45 g). Analyzed by liquid chromatography-mass spectrometry (LC-MS) (condition B): retention time (t R) = 0.47 min; molecular ion peak [M + H]+: 237.19.

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 2, p. 278 - 292
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 14, p. 6690 - 6708
[3] Patent: US2004/122237, 2004, A1. Location in patent: Page 247-248
[4] Patent: WO2004/18419, 2004, A2. Location in patent: Page 260
[5] Patent: US2010/81653, 2010, A1. Location in patent: Page/Page column 12

5-(4-Methylpiperazin-1-yl)-2-nitroaniline Preparation Products And Raw materials

Raw materials

1-Methylpiperazine 5-Fluoro-2-nitroaniline 5-Chloro-2-nitroaniline N-Methyl-2-pyrrolidone Triethylamine

Preparation Products

Hoechst 33342

5-(4-Methylpiperazin-1-yl)-2-nitroaniline Suppliers

Global Suppliers ( 160)

Supplier	Tel	Email	Country	ProdList	Advantage
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
ZHIWE CHEMTECH CO LTD	021-20221225 13917446399	zwchem@163.com	China	527	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	21-57721279 18121011378	sales@shydchem.com.cn	China	998	56
Nanjing Habo Medical Technology Co., Ltd.	13376080562 13376090521	sales@habotech.com	China	726	60
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
Guangzhou Isun Pharmaceutical Co., Ltd	55
J & K SCIENTIFIC LTD.	76
ZHIWE CHEMTECH CO LTD	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	56
Nanjing Habo Medical Technology Co., Ltd.	60
Accela ChemBio Co.,Ltd.	64
Shanghai Longsheng chemical Co.,Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from 5-(4-Methylpiperazin-1-yl)-2-nitroaniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	5-(4-methylpiperazin-1-yl)-2-nitroaniline 23491-48-7		10kg	99%	10 tons	Qingdao RENAS Polymer Material Co., Ltd.
2026-09-02	5-(4-Methylpiperazin-1-yl)-2-nitroaniline 23491-48-7	$2.00-10.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2024-11-26	5-(4-Methylpiperazin-1-yl)-2-nitroaniline 23491-48-7		1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd

5-(4-methylpiperazin-1-yl)-2-nitroaniline
23491-48-7
$0.00
99%
Qingdao RENAS Polymer Material Co., Ltd.

5-(4-Methylpiperazin-1-yl)-2-nitroaniline
23491-48-7
$2.00-10.00
99%
Henan Fengda Chemical Co., Ltd

5-(4-Methylpiperazin-1-yl)-2-nitroaniline
23491-48-7
98%
Nanjing Fred Technology Co., Ltd

5-(4-Methylpiperazin-1-yl)-2-nitroaniline Spectrum

5-(4-Methylpiperazin-1-yl)-2-nitroaniline(23491-48-7)¹HNMR

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1of4

5-(4-METHYL-PIPERAZIN-1-YL)-2-NITROANILINE 5-(4-METHYLPIPERAZIN-1-YL)-2-NITROPHENYLAMINE 5-(4-METHYLPIPERAZINO)-2-NITROANILINE 5-(4-Methyl-1-piperazinyl)-2-nitroaniline 5-(4-Methylpiperazino)-2-Nitro 1-(3-Amino-4-nitrophenyl)-4-methylpiperazine BUTTPARK 17\04-69 BENZENAMINE, 5-(4-METHYL-1-PIPERAZINYL)-2-NITRO- 5-(4-methylpiperazin-1-yl)-2-nitrobenzenamine 5-(4-Methylpiperazin-1-yl)-2-nitroaniline-7 5-(4-methylpiperazine) -2-nitroaniline SIRT6-IN-6 23491-48-7 C11H16N4O2 Piperazines API intermediates Piperazidine intermediates