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Methylglyoxal 1,1-dimethyl acetal

Methylglyoxal 1,1-dimethyl acetal Structure
Methylglyoxal 1,1-dimethyl acetal structure
CAS No.
6342-56-9
Chemical Name:
Methylglyoxal 1,1-dimethyl acetal
Synonyms
1,1-Dimethoxypropan-2-one;2,2-DiMethoxypropanal;PYRUVIC ALDEHYDE DIMETHYL ACETAL;1,1-DIMETHOXYACETONE;2-Propanone, 1,1-dimethoxy-;METHYLGLYOXAL DIMETHYL ACETAL;Pyruvic aL;Pyruvaldehyde 1;1,1-Dimethoxyaceton;Methylglyoxal 1,1-di
CBNumber:
CB0166610
Molecular Formula:
C5H10O3
Molecular Weight:
118.13
MDL Number:
MFCD00008758
MOL File:
6342-56-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:20:44
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Methylglyoxal 1,1-dimethyl acetal Properties

Melting point -57 °C
Boiling point 143-147 °C(lit.)
Density 0.976 g/mL at 25 °C(lit.)
vapor pressure 11hPa at 20℃
refractive index n20/D 1.398(lit.)
Flash point 100 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form Liquid
color Clear colorless to yellow
Water Solubility MISCIBLE
BRN 1560557
InChI 1S/C5H10O3/c1-4(6)5(7-2)8-3/h5H,1-3H3
InChIKey ULVSHNOGEVXRDR-UHFFFAOYSA-N
SMILES COC(OC)C(C)=O
LogP -0.199 (est)
CAS DataBase Reference 6342-56-9
FDA UNII 3772KY264D
NIST Chemistry Reference 2-Propanone, 1,1-dimethoxy-(6342-56-9)
EPA Substance Registry System 2-Propanone, 1,1-dimethoxy- (6342-56-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319
Precautionary statements  P210-P302+P352-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  10-36/38
Safety Statements  26-36-16
RIDADR  UN 1224 3/PG 3
WGK Germany  1
TSCA  TSCA listed
HazardClass  3
PackingGroup  III
HS Code  29145000
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
REACH Registrations Active
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

Methylglyoxal 1,1-dimethyl acetal price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 170216 Methylglyoxal 1,1-dimethyl acetal ≥97% 6342-56-9 100ml $101 2026-04-30 Buy
Sigma-Aldrich 170216 Methylglyoxal 1,1-dimethyl acetal ≥97% 6342-56-9 500ml $191 2026-04-30 Buy
TCI Chemical P1264 Pyruvic Aldehyde Dimethyl Acetal >97.0%(GC) 6342-56-9 25mL $77 2026-04-30 Buy
TCI Chemical P1264 Pyruvic Aldehyde Dimethyl Acetal >97.0%(GC) 6342-56-9 100mL $158 2026-04-30 Buy
AK Scientific J93693 Pyruvic aldehyde dimethyl acetal 97% 6342-56-9 5mL $13 2026-06-04 Buy
Product number Packaging Price Buy
170216 100ml $101 Buy
170216 500ml $191 Buy
P1264 25mL $77 Buy
P1264 100mL $158 Buy
J93693 5mL $13 Buy

Methylglyoxal 1,1-dimethyl acetal Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellow liquid

Uses

Pyruvic Aldehyde Dimethyl Acetal is used in the preparation of MCL1 inhibitors S63845 which is tolerable and effective in diverse cancer models. Also, acts as a synthetic reagent for the preparation of 8novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Selective inhibition of neuronal nitric oxide synthase is an important therapeutic approach to target neurodegenerative disorders.

Uses

Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 2642, 1976 DOI: 10.1021/jo00877a030

Synthesis

It is produced in two main stages. Stage 1: Preparation of acetone aldehyde monohydrate. 1,2-Propanediol undergoes gas-phase oxidation over a modified electrolytic silver catalyst. Optimal conditions: temperature 350-650C, oxygen/alcohol ratio 1.1-1.2, space velocity 18,000-20,000 h1. Conversion is 100%, methylglyoxal selectivity is 76%. Stage 2: Preparation of Methylglyoxal 1,1-dimethyl acetal. acetone aldehyde monohydrate reacts with methanol under reflux catalyzed by a modified resin. Distillation removes low-boilers and methanol. Steam distillation gives a crude solution. Dichloromethane extraction and rectification yield the pure product.

Methylglyoxal 1,1-dimethyl acetal Preparation Products And Raw materials

Raw materials

Methylglyoxal

Preparation Products

4-Dimethoxymethyl-6-hydroxypyrimidine-2-thiol 3-Methylisoquinoline 2-Methylsulfanyl-pyrimidine-4-carbaldehyde 1H-Imidazole-1-carboxylic acid, 2-amino-4-(dimethoxymethyl)-,1,1-dimethylethyl ester 4-(Dimethoxymethyl)-2-(methylsulfonyl)pyrimidine
ethyl 5,5-dimethoxy-2,4-dioxopentanoate

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Methylglyoxal 1,1-dimethyl acetal Suppliers

Global( 386)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenyang NovPharm Technology Co., Ltd. 024-24165786 18624046968 novpharm@hotmail.com China 32 62
Jinan Yuanze Biotechnology Co., LTD 15063396929; 15063396929 978101703@qq.com China 59 58
Shandong Yinsheng Pharmaceutical Technology Co., Ltd 18865947357 liguiling16888@163.com China 32 58
Fujian Fangkang Import and Export Trading Co., Ltd 18368168117 40628309@qq.com China 5 58
Qingdao Dexin Chemical Co. LTD 18560810705 354907727@qq.com China 299 58
Creasyn Finechem(Tianjin) Co., Ltd. 022-83946278 13820372920 sales@creasyn.com China 968 68
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Shenyang NovPharm Technology Co., Ltd. 62
Jinan Yuanze Biotechnology Co., LTD 58
Shandong Yinsheng Pharmaceutical Technology Co., Ltd 58
Fujian Fangkang Import and Export Trading Co., Ltd 58
Qingdao Dexin Chemical Co. LTD 58
Creasyn Finechem(Tianjin) Co., Ltd. 68
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84

View Lastest Price from Methylglyoxal 1,1-dimethyl acetal manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methylglyoxal 1,1-dimethyl acetal pictures 2026-03-20 Methylglyoxal 1,1-dimethyl acetal
6342-56-9
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
1,1-Dimethoxyacetone pictures 2025-06-27 1,1-Dimethoxyacetone
6342-56-9
 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
1,1-Dimethoxyacetone pictures 2025-06-20 1,1-Dimethoxyacetone
6342-56-9
 $10.00-100.00 1kg 0.99 20000kg per day Hebei Yanxi Chemical Co., Ltd.

Methylglyoxal 1,1-dimethyl acetal Spectrum

Methylglyoxal 1,1-dimethyl acetal(6342-56-9)MSMethylglyoxal 1,1-dimethyl acetal(6342-56-9)1HNMRMethylglyoxal 1,1-dimethyl acetal(6342-56-9)13CNMRMethylglyoxal 1,1-dimethyl acetal(6342-56-9)IR1Methylglyoxal 1,1-dimethyl acetal(6342-56-9)Raman

6342-56-9(Methylglyoxal 1,1-dimethyl acetal)Related Search:

Chloroacetaldehyde dimethyl acetal Paraldehyde Acetal 1,1-Dimethoxyethane Benzaldehyde dimethyl acetal
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Bromoacetaldehyde dimethyl acetal Methoxyacetone 4-Methoxyphenylacetone Benzhydrol 2,2-Dimethoxypropane
1,1,2-Trimethoxyethane N,N-Dimethylformamide Dimethyl fumarate Methylglyoxal Dimethyl Acetal

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PYRUVALDEHYDE DIMETHYLACETAL PYRUVALDEHYDE 1,1-DIMETHYL ACETAL PYRUVALDEHYDE-1-DIMETHYL ACETAL Methylglyoxal dimethyl acetal~Pyruvaldehyde dimethyl acetal PYRUVIC ALDEHYDE DIMETHYL ACETAL, 97+% PYRUVIC ALDEHYDE DIMETHYL ACETAL 98% PYRUVIC ALDEHYDE DIMETHYL ACETAL(INTERMEDIATE OF B-CAROTENE) 2-Propanone, 1,1-dimethoxy- (9CI) 2-Propanone, 1,1-dimethoxy- PYRUVICALDEHYDEDIETHYLACETAL 1,1-Dimethoxyaceton Pyruvic aldehyde dimethyl aecetal 1,1-Dimethoxypropane-2-one 2-Oxopropanal dimethyl acetal Pyruvic aldehyde dimethyl acetal,98% 1,1-Dimethoxypropanone 1,1-Dimethoxyacetone, Pyruvaldehyde-1-dimethyl acetal, Pyruvic aldehyde dimethyl acetal Pyruvic aL Methylglyoxal 1,1-di Acetone, Methanol aldolase two 1,1-Dimethoxypropan-2-one, Methylglyoxal dimethyl acetal, Pyruvaldehyde dimethyl acetal 1,1-Dimethoxyaceton (Methylglyoxaldimethylacetal) 1,1-Dimethoxyacetone 1,1-Dimethoxy-2-propanone Methylglyoxal Dimethyl Acetal Methylglyoxal 1,1-diMethyl acetal >=97% 1,1-DIMETHOXY-2-PROPANONE 1,1-DIMETHOXYACETONE Methylglyoxal 1,1-dimethyl aceta ACETYLFORMALDEHYDE DIMETHYL ACETAL ALPHA,ALPHA-DIMETHOXYACETONE METHYLGLYOXAL 1, 1-DIMETHYL ACETAL 1,1-dimethoxy-2-propanon Dimethoxymethyl methyl ketone Acetone aldehyde condensation of Methanol Pyruvaldehyde dimethyl acetal estimate PyruvicAldehydeDimethylAcetal> Methylglyoxaldimethyl acetal (Pyruvicaldehyde dimethylacetal) Pyruvaldehyde 1 Pyruvaldehyde dimethyl acetal English name: Pyruvic aldehyde dimethyl acetal Methylglyoxal Dimethyl Acetal [MGDA] Acetone aldehyde dimethyl acetal 1,1-Dimethoxypropan-2-one 2,2-DiMethoxypropanal METHYLGLYOXAL DIMETHYL ACETAL PYRUVIC ALDEHYDE DIMETHYL ACETAL 6342-56-9 6342-59-9 CH3COCHOCH32 Organic Building Blocks Oxygen Compounds Acetals/Ketals/Ortho Esters Building Blocks ACETYLGROUP Aldehydes blocks BuildingBlocks ketone (intermediate of -carotene)