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Acetylacetaldehyde dimethyl acetal

Acetylacetaldehyde dimethyl acetal structure

CAS No.: 5436-21-5

Chemical Name:: Acetylacetaldehyde dimethyl acetal

Synonyms: 4,4-DIMETHOXY-2-BUTANONE;KBA;AADMA;4,4-dimethoxybutanone;4,4-dimethoxybutanon;1,1-DIMETHOXY-3-BUTANONE;2-Butanone, 4,4-dimethoxy-;4,4-Dimethoxy-2-butanone (DMB);3-OXOBUTYRALDEHYDE DIMETHYLACETAL;FADMA

CBNumber:: CB3708585

Molecular Formula:: C6H12O3

Molecular Weight:: 132.16

MDL Number:: MFCD00008789

MOL File:: 5436-21-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:45:37

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Acetylacetaldehyde dimethyl acetal Properties

Melting point	-82 °C
Boiling point	70-73 °C/20 mmHg (lit.)
Density	0.996 g/mL at 25 °C (lit.)
refractive index	n20/D 1.414(lit.)
FEMA	3381 \| 3-OXOBUTANAL DIMETHYL ACETAL
FLAVIS Number	06.038 \| 4,4-Dimethoxybutan-2-one
Flash point	121 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	soluble in Chloroform, Ethyl Acetate
form	Liquid
color	Clear colorless to yellow
Odor	at 0.10 % in dipropylene glycol. ethereal musty nutty alcoholic bitter
Odor Type	ethereal
Water Solubility	decomposes
JECFA Number	593
BRN	1702372
InChI	1S/C6H12O3/c1-5(7)4-6(8-2)9-3/h6H,4H2,1-3H3
InChIKey	PJCCSZUMZMCWSX-UHFFFAOYSA-N
SMILES	COC(CC(C)=O)OC
LogP	0.33
CAS DataBase Reference	5436-21-5(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	3-OXOBUTANAL, DIMETHYL ACETAL
EWG's Food Scores	1
FDA UNII	0IZ188B2ZA
NIST Chemistry Reference	2-Butanone, 4,4-dimethoxy-(5436-21-5)
EPA Substance Registry System	2-Butanone, 4,4-dimethoxy- (5436-21-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Warning

Hazard statements

H226

Precautionary statements

P210-P233-P240-P241-P242-P243

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 1989 3/PG 3

WGK Germany

RTECS

EL7592500

TSCA

TSCA listed

HazardClass

PackingGroup

III

HS Code

29145000

Storage Class

3 - Flammable liquids

Hazard Classifications

Flam. Liq. 3

REACH Registrations

Inactive

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
1		0

Acetylacetaldehyde dimethyl acetal price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	380067	4,4-Dimethoxy-2-butanone technical grade, ≥90%	5436-21-5	100ml	$100	2026-04-30	Buy
Sigma-Aldrich	380067	4,4-Dimethoxy-2-butanone technical grade, ≥90%	5436-21-5	500ml	$153	2026-04-30	Buy
TCI Chemical	D1157	1,1-Dimethoxy-3-butanone >90.0%(GC)	5436-21-5	25mL	$27	2026-04-30	Buy
TCI Chemical	D1157	1,1-Dimethoxy-3-butanone >90.0%(GC)	5436-21-5	100mL	$61	2026-04-30	Buy
Usbiological	233570	4,4-Dimethoxy-2-butanone ≥92% (GC) ≥92%(GC)	5436-21-5	25g	$156	2026-06-03	Buy

Product number	Packaging	Price	Buy
380067	100ml	$100	Buy
380067	500ml	$153	Buy
D1157	25mL	$27	Buy
D1157	100mL	$61	Buy
233570	25g	$156	Buy

Acetylacetaldehyde dimethyl acetal Chemical Properties, Uses, Production

Chemical Properties

Clear colorless to yellow liquid

Uses

Acetaldehyde dimethyl acetal is used as a flavoring agent. It is also used in the preparation of (R)-4,4-dimethoxy-2-butanol, pyrazoles and pyrimidines. Further, it is used in the preparation of N,N-diethyl-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]-pyrimidin-3-yl]acetamide and acetoacetaldehyde.

Uses

4,4-Dimethoxy-2-butanone (β-ketobutyracetal) may be used in the preparation of:

(R)-4,4-dimethoxy-2-butanol
pyrazoles and pyrimidines
[7,16-dihydro- 6,15( 17)-dimetbyldibenzo[b,i]-[1,4,8,11]tetrilazacyclotetradecinato-N⁵,N⁹,N¹⁴,N¹⁸]nickel{II)

Definition

ChEBI: 4,4-Dimethoxy-2-butanone is a ketone.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 3765, 1976 DOI: 10.1021/jo00885a028
Tetrahedron Letters, 28, p. 6657, 1987 DOI: 10.1016/S0040-4039(00)96938-7

General Description

4,4-Dimethoxy-2-butanone (Acetylacetaldehyde dimethylacetal) is a ketone.

Synthesis

107-31-3

67-64-1

5436-21-5

Methanol was added to the 3L and 2L flasks, 257 g of sodium methanolate (1.852 mol) was dissolved in methanol and the temperature was maintained at 40 °C. A mixture of 118.1 g of acetone (2.036 mol) and 333.6 g of methyl formate (5.555 mol) was added dropwise to the reaction system at 40 °C for 4 hours. After the dropwise addition, stirring was continued for 1 h. Subsequent cooling to 20 °C gave 184 g of formalin acetone sodium salt (92% quantitative yield by HPLC using sodium methanol as standard). The resulting formalin acetone sodium salt was transferred to a necked down 3L reactor, methanol was added, and 6.2 g of sulfuric acid (0.063 mol) was added, keeping the temperature at 30 °C. The reaction solution of formylacetone was added to the reaction system simultaneously with 93.8 g of sulfuric acid (0.957 mol) dropwise at 30 °C or lower for 1 hour, during which the pH was maintained between 0-1. After completion of the dropwise addition, the mixture was continued to be stirred at the same temperature for 4 hours and subsequently cooled to 20°C. The pH was adjusted to 7-8 with 20% sodium hydroxide solution, the resulting salt was removed by filtration, and the distillate was collected by distillation to give a final 195.6 g of 4,4-dimethoxy-2-butanone (80.0% yield based on sodium methanol and 87.0% yield based on formalin acetone sodium salt).

Toxics Screening Level

The ITSL for 4,4-dimethoxy-2-butanone is 20 μg/m3 annual average.

References

[1] Patent: KR2017/17372, 2017, A. Location in patent: Paragraph 0047; 0065-0070

Acetylacetaldehyde dimethyl acetal Preparation Products And Raw materials

Raw materials

Methyl formate Acetone Sodium Methoxide Sulfuric acid Methanol

Preparation Products

Methyl 3-methyl-2-furoate 1-Methoxy-3-trimethylsiloxy-1,3-butadiene 2-Methanesulfonyl-4-methyl-pyrimidine 5-Methyl-4-isoxazolesulfonyl chloride Ethyl 5-methyl-1H-pyrrole-2-carboxylate

4-Methoxy-3-buten-2-one 4-Methyl-pyrimidine-2-sulfonyl fluoride 3-Methyl-2-furoic acid 3-Methyl-1-phenylpyrazole 4-Methyl-2-(methylsulfanyl)pyrimidine

4 4-Dimethoxy-2-methyl-2-butanol 97 2-Fluoro-6-methylnaphthalene 5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidine

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Acetylacetaldehyde dimethyl acetal Suppliers

Global Suppliers ( 486)

Supplier	Tel	Email	Country	ProdList	Advantage
Weifang Mingran Chemical Co., Ltd.	QQ117761326 QQ2829453795 15063661899;	mingranchem@163.com	China	493	58
Chemspon Bio-Tech Co., Ltd	0571-88937695 88937835 13606537248	sales@chemspon.com	China	257	58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
Liaoning bomei pharmaceutical technology co. LTD.	24-24524889 18640309171	236415745@qq.com	China	44	58
Shandong Yukun Chemical Industry Co. LTD	18660690289	sales@yukunchem.com	China	45	58
Hubei yongkuo Technology Co., Ltd	027-59223108 15972152991	1248580099@qq.com	China	9910	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84

Supplier	Advantage
Weifang Mingran Chemical Co., Ltd.	58
Chemspon Bio-Tech Co., Ltd	58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
Liaoning bomei pharmaceutical technology co. LTD.	58
Shandong Yukun Chemical Industry Co. LTD	58
Hubei yongkuo Technology Co., Ltd	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84

View Latest Price from Acetylacetaldehyde dimethyl acetal manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	4,4-Dimethoxy-2-butanone 5436-21-5		1KG	99%	100mt/year	Jinan Finer Chemical Co., Ltd
2026-08-20	Acetylacetaldehyde dimethyl acetal 5436-21-5	$1.10	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2026-05-28	4, 4-Dimethoxy-2-Butanone 5436-21-5	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

4,4-Dimethoxy-2-butanone
5436-21-5
$0.00
99%
Jinan Finer Chemical Co., Ltd

Acetylacetaldehyde dimethyl acetal
5436-21-5
$1.10
99.9%
Dideu Industries Group Limited

4, 4-Dimethoxy-2-Butanone
5436-21-5
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

Acetylacetaldehyde dimethyl acetal Spectrum

Acetylacetaldehyde dimethyl acetal(5436-21-5)MS Acetylacetaldehyde dimethyl acetal(5436-21-5)¹HNMR Acetylacetaldehyde dimethyl acetal(5436-21-5)¹³CNMR Acetylacetaldehyde dimethyl acetal(5436-21-5)IR1 Acetylacetaldehyde dimethyl acetal(5436-21-5)IR2 Acetylacetaldehyde dimethyl acetal(5436-21-5)Raman

5436-21-5 (Acetylacetaldehyde dimethyl acetal) Related Search:

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ACETYLACETALDEHYDE DIMETHYL ACETAL ACETOACETALDEHYDE-1,1-DIMETHYL ACETAL ACETOACETALDEHYDE DIMETHYL ACETAL 3-OXOBUTYRALDEHYDE DIMETHYLACETAL 3-KETOBUTYRALDEHYDE-1-DIMETHYLACETAL 3-KETOBUTYRALDEHYDE DIMETHYL ACETAL 3-KETOBUTYRIC ALDEHYDE 1-DIMETHYL ACETAL FEMA 3381 FADMA FORMYLACETONE DIMETHYL ACETAL 4,4-DiMethxoy-2-butanone Acetoacetaldehyde, 1-(diMethyl acetal) (6CI,7CI,8CI) NSC 59721 4,4- twoMethoxy -2-butanone 3-Oxobutyraldehyde 1-(dimethylacetal) 4,-Dimethoxy-2-Butanone Acetylacetaldehyde dimethyl acetal, tech., 90% Acetylacetaldehydedimethylacetal,90+% 2-ACETOACTALDEHYDE DIMETHYL ACETAL 2-Butanone, 4,4-dimethoxy- 4,4-Dimethoxyl butan-2-one 4,4-DIMETHOXY BUTAN-2-ONE 4,4-dimethoxybutanon 1,1-DIMETHOXY BUTANONE-3 1,1-DIMETHOXY-3-BUTANONE 3-OXOBUTANALDIMETHYLACETAL 4,4-DIMETHOXY-2-BUTANONE[FOR NEVIRAPINE] Acetylacetaldehyde dimethyl acetal, 3-Ketobutyraldehyde dimethyl acetal, 3-Oxobutyraldehyde dimethylacetal 3-Ketobutyraldehyde dimethyl acetal, 3-Oxobutyraldehyde dimethylacetal, 4,4-Dimethoxy-2-butanone, Acetylacetaldehyde dimethylacetal 3-Ketobutyraldehyde dimethyl acetal, 4,4-Dimethoxy-2-butanone, AADMA, Acetylacetaldehyde dimethylacetal 3-Ketobutyraldehyde dimethyl acetal, 4,4-Dimethoxy-2-butanone, Acetylacetaldehyde dimethylacetal 4,4-Dimethoxybutanon 4,4-Dimethoxy-2-butanone 1,1-Dimethoxy-3-butanone Acetoacetaldehyde dimethylacetal 3-Ketobutyraldehyde dimethyl acetal 3-Oxobutanal dimethylacetal 3-Ketobutyraldehyde dimethyl acetal 3-Oxobutanal dimethylacetal Acetylacetaldehyde dimethyl acetal,92% 4,4-Dimethoxy-2-butanone ,90% Acetylacetaldehyde d Acetylacetaldehyde diMethyl acetal, 92% 250ML 4,4-Dimethoxy-2-butanone (DMB) ACETYLACETALDEHYD-DIMETHYLACETAL 95% 3-OXOBUTYRALDEHYDE DIMETHYLACETAL,WACKER QUALITY ACETYLACETALDEHYDE DIMETHYL ACETAL, TECH ., 90+% 4,4-dimethoxy-2-butanon Acetoacetaldehyde, 1-(dimethyl acetal) acetoacetaldehyde,1-(dimethylacetal) Acetylacetaldehyddimethylacetal Acetylacetaldhydedimethylacetal beta-Oxobutyraldehyde dimethyl acetal beta-oxobutyraldehydedimethylacetal Acetylacetaldehyde dimethyl acetal, technical, 90% Acetoacetaldehyde-1,1-dimethyl acetal for synthesis 4,4-dimethoxy-2-butyl copper 1,1-Dimethoxy-3-butanone > 4,4-Dimethoxy-2-butone Acetylacetaldehyde dimethyl acetal 92% 4,4-DIMETHOXY-2-BUTANONE 4,4-dimethoxybutanone AADMA KBA