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2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE structure

CAS No.: 1074-68-6

Chemical Name:: 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE

Synonyms: 2-(Methylthio)pyrimidine-4-carbaldehyde;4-ForMyl-2-MethylthiopyriMidine;2-(Methylthio)pyridine-4-carbaldehyde;2-Methylthiopyrimidine-4-carboxaldehyde;2-(Methylthio)-4-pyrimidinecarbaldehyde;2-MethylsulfanylpyriMidin-4-carbaldehyde;2-(Methylthio)-4-pyrimidinecarboxaldehyde;2-METHYLTHIO-4-PYRIMIDINE CARBOXYALDEHYDE;2-methylthioylpyrimidine-4-methylaldehyde;2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE

CBNumber:: CB2384412

Molecular Formula:: C6H6N2OS

Molecular Weight:: 154.19

MDL Number:: MFCD02683211

MOL File:: 1074-68-6.mol

MSDS File:: SDS

Last updated:2026-05-28 00:24:01

Product description	Number	Pack Size	Price
2-(Methylthio)pyrimidine-4-carbaldehyde >97%	OR907027	250mg	$21
2-(Methylthio)pyrimidine-4-carbaldehyde >97%	OR907027	1g	$54
2-(Methylthio)pyrimidine-4-carbaldehyde >97%	OR907027	5g	$262
2-(Methylthio)pyrimidine-4-carbaldehyde >97%	OR907027	25g	$1214
2-(Methylthio)pyrimidine-4-carbaldehyde >97%	OR907027	100g	$4521
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2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE Properties

Melting point	68°C
Boiling point	110-112 °C(Press: 0.001 Torr)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	solid
pka	-0.87±0.23(Predicted)
color	Off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
Safety Statements	24/25
HS Code	2933599590

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR907027	2-(Methylthio)pyrimidine-4-carbaldehyde >97%	1074-68-6	250mg	$21	2026-06-04	Buy
Apolloscientific	OR907027	2-(Methylthio)pyrimidine-4-carbaldehyde >97%	1074-68-6	1g	$54	2026-06-04	Buy
Apolloscientific	OR907027	2-(Methylthio)pyrimidine-4-carbaldehyde >97%	1074-68-6	5g	$262	2026-06-04	Buy
Apolloscientific	OR907027	2-(Methylthio)pyrimidine-4-carbaldehyde >97%	1074-68-6	25g	$1214	2026-06-04	Buy
Apolloscientific	OR907027	2-(Methylthio)pyrimidine-4-carbaldehyde >97%	1074-68-6	100g	$4521	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR907027	250mg	$21	Buy
OR907027	1g	$54	Buy
OR907027	5g	$262	Buy
OR907027	25g	$1214	Buy
OR907027	100g	$4521	Buy

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE Chemical Properties,Uses,Production

Uses

4-Formyl-2-methylthiopyrimidine is used in the synthesis of cytokine synthesis inhibitors.

Synthesis

4-(Dimethoxymethyl)-2-(methylthio)-pyrimidine

180869-36-7

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE

1074-68-6

Example 4 Synthesis of 2-(methylthio)pyrimidine-4-carboxaldehyde (4): 4-(dimethoxymethyl)-2-(methylthio)pyrimidine (3) (53.7 g, 268 mmol) was slowly added to an aqueous solution of 1.2N HCl (300 mL, 268 mmol, 1.0 eq.) at 60 °C with continuous stirring for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and neutralized by slow addition of solid sodium bicarbonate. Subsequently, the crude product was extracted with ether (3 x 150 mL) and the combined organic layers were concentrated under reduced pressure to afford the target product 2-(methylthio)pyrimidine-4-carboxaldehyde (4) as a yellow solid (14.2 g, 34% yield).LC-MS m/z 155 (M+1). Reference: WO 2006/009734 A1, p. 67.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 3, p. 1067 - 1088
[2] Patent: WO2016/7966, 2016, A2. Location in patent: Paragraph 0024
[3] Journal of Medicinal Chemistry, 2018,
[4] Patent: US2011/152235, 2011, A1. Location in patent: Page/Page column 67
[5] Patent: WO2011/103289, 2011, A2. Location in patent: Page/Page column 73; 74

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE synthesis

Synthesis of 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE from Sodium carbonate and 4-(Dimethoxymethyl)-2-(methylthio)-pyrimidine

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

4-IODO-2-(METHYLTHIO)PYRIMIDINE 4-(Dimethoxymethyl)-2-(methylthio)-pyrimidine Sodium bicarbonate Hydrochloric acid Methylglyoxal 1,1-dimethyl acetal

Iodomethane Sodium carbonate

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Preparation Products

2-Thiomethylpyrimidine-4-carboxylic acid

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE Suppliers

Global( 152)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-15225627621 +86-13213167925	jiuyitime@fdachem.com	China	16505	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30203	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
Dideu Industries Group Limited	+8617392712697	1022@dideu.com	China	29095	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49859	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43303	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 1074-68-6	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-08-20	2-Methylsulfanylpyrimidine-4-carbaldehyde 1074-68-6	$1.60-6.60	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2020-01-10	2-Methylsulfanylpyrimidine-4-carbaldehyde 1074-68-6	$1.00	1g	98%	200kgs	Career Henan Chemical Co

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE
1074-68-6
$1.10
99.00%
Dideu Industries Group Limited

2-Methylsulfanylpyrimidine-4-carbaldehyde
1074-68-6
$1.60-6.60
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2-Methylsulfanylpyrimidine-4-carbaldehyde
1074-68-6
$1.00
98%
Career Henan Chemical Co

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE Spectrum

2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE(1074-68-6)¹HNMR

1074-68-6(2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE)Related Search:

METHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 97 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

2-Methylsulfanyl-pyrimidine-5-carbaldehyde ,95%,2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE PYRIMIDINE-4-CARBOXALDEHYDE IFLAB-BB F2124-0044 2-PROPYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 2-ISOPROPYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE

6-Hydroxy-2-(methylsulfanyl)-4-pyrimidinecarboxylic acid METHYL 6-METHYL-2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLATE AKOS BBS-00001671 4-METHYLAMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 4-AMINO-6-CHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE

4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE AKOS BBS-00001669 5,6-DIMETHOXY-2-METHYLSULFANYL-PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER

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2-Methylthiopyrimidine-4-carboxaldehyde 2-Methylthio-4-pyrimidine carboxzyaldehyde 2-METHYLTHIO-4-PYRIMIDINE CARBOXYALDEHYDE 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE 2-MethylsulfanylpyriMidin-4-carbaldehyde 4-ForMyl-2-MethylthiopyriMidine 2-(Methylthio)pyridine-4-carbaldehyde 4-PyriMidinecarboxaldehyde, 2-(Methylthio)- 2-(Methylthio)-4-pyrimidinecarbaldehyde 2-(Methylthio)-4-pyrimidinecarboxaldehyde 2-METHYLSULFANYL-PYRIMIDINE-4-CARBALDEHYDE ISO 9001：2015 REACH 2-methylthioylpyrimidine-4-methylaldehyde 2-(Methylthio)pyrimidine-4-carbaldehyde 1074-68-6 1074-68-8 Heterocycle-Pyrimidine series Pyrimidine series