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3-Chloro-2,5-dimethylpyrazine

3-Chloro-2,5-dimethylpyrazine Structure
3-Chloro-2,5-dimethylpyrazine structure
CAS No.
95-89-6
Chemical Name:
3-Chloro-2,5-dimethylpyrazine
Synonyms
2,5-Dimethyl-3-chloropyrazine;3-CHLORO-2,5-DIMETHYLPIAZINE;3-Chloro-2,5-dimethylpyrazine;Pyrazine, 3-chloro-2,5-dimethyl-;3-Chloro-2,5-dimethylpyrazine,93%;3-CHLORO-2,5-DIMETHYL-1,4-DIAZINE;3-Chloro-2,5-dimethylpyrazine >3-Chloro-2,5-diMethylpyrazine 98%;3-Chloro-2,5-diMethylpyrazine, 97+%;3-CHLORO-2,5-DIMETHYLPYRAZINE ISO 9001：2015 REACH
CBNumber:
CB0176239
Molecular Formula:
C6H7ClN2
Molecular Weight:
142.59
MDL Number:
MFCD00006143
MOL File:
95-89-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:47:34
Request For Quotation

3-Chloro-2,5-dimethylpyrazine Properties

Boiling point 66-69 °C/9 mmHg (lit.)
Density 1.181 g/mL at 25 °C (lit.)
refractive index n20/D 1.527(lit.)
Flash point 182 °F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form clear liquid
pka -0.11±0.10(Predicted)
color Colorless to Light orange to Yellow
InChI 1S/C6H7ClN2/c1-4-3-8-5(2)6(7)9-4/h3H,1-2H3
InChIKey NNBALVIZMGWZHS-UHFFFAOYSA-N
SMILES Cc1cnc(C)c(Cl)n1
CAS DataBase Reference 95-89-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII T2GK7ZW2ED
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H227
Precautionary statements  P210-P280-P403+P235-P501
PPE Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Safety Statements  24/25
WGK Germany  3
RTECS  UQ2462000
HS Code  29339900
Storage Class 10 - Combustible liquids
NFPA 704
2
1 0

3-Chloro-2,5-dimethylpyrazine price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C38400 3-Chloro-2,5-dimethylpyrazine 98% 95-89-6 25g $74.6 2023-06-20 Buy
TCI Chemical C2040 3-Chloro-2,5-dimethylpyrazine >95.0%(GC) 95-89-6 5g $103 2026-04-30 Buy
Usbiological 269509 3-Chloro-2,5-dimethylpyrazine Asreported 95-89-6 10g $460 2026-06-03 Buy
Usbiological 269509 3-Chloro-2,5-dimethylpyrazine Asreported 95-89-6 25g $744 2026-06-03 Buy
Usbiological 269509 3-Chloro-2,5-dimethylpyrazine Asreported 95-89-6 50g $1097 2026-06-03 Buy
Product number Packaging Price Buy
C38400 25g $74.6 Buy
C2040 5g $103 Buy
269509 10g $460 Buy
269509 25g $744 Buy
269509 50g $1097 Buy

3-Chloro-2,5-dimethylpyrazine Chemical Properties,Uses,Production

Chemical Properties

Brown liquid

Uses

3-Chloro-2,5-dimethylpyrazine participates in cross-coupling reactions involving chlroropyrazines with 1-substituted indoles. Occasionally this reaction is catalyzed by iron.

Synthesis

2,5-DIMETHYL PYRAZINE N-OXIDE

6890-37-5

3-CHLORO-2,5-DIMETHYLPYRAZINE

95-89-6

General procedure for the synthesis of 3-chloro-2,5-dimethylpyrazine from 2,5-dimethylpyrazine 1-oxide: 2,5-dimethylpyrazine 1-oxide (7,15.0 g, 121 mmol) and phosphorous trichloride (POCl3, 55.1 g, 360 mmol) were mixed, and the mixture was stirred and heated for 30 min at 60 °C. (Note: Caution is required during handling, as there have been reports of explosions during mixing). Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured in batches into ice water. The pH was adjusted to alkaline with 20% aqueous sodium hydroxide (NaOH) and then extracted with ether (Et2O). The organic phase was washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. Distillation of the residue gave 12.2 g (71% yield) of 3-chloro-2,5-dimethylpyrazine as a light yellow oil with a boiling point of 98-100 °C/40 Torr. Its infrared spectrum (νmax, membrane method) showed characteristic absorption peaks: 3045 (w), 2999 (w), 2962 (w), 2925 (w), 1567 (w), 1519 ( w), 1454 (s), 1377 (m), 1329 (s), 1313 (s), 1248 (m), 1168 (m), 1088 (s), 968 (m), 456 (m) cm-1. NMR hydrogen spectrum (δH, CDCl3): 2.49 (3H, s), 2.59 (3H, s), 8.23 (1H, s); NMR carbon spectrum (δC, CDCl3): 21.2,22.3,142.1,148.3,150.1,151.7.

References

[1] European Journal of Organic Chemistry, 2010, # 14, p. 2687 - 2695
[2] Tetrahedron, 2017, vol. 73, # 32, p. 4766 - 4769
[3] Organic Letters, 2012, vol. 14, # 10, p. 2576 - 2578
[4] Journal of the American Chemical Society, 1951, vol. 73, p. 2949
[5] Journal of the Chemical Society, 1947, p. 1183

3-Chloro-2,5-dimethylpyrazine Preparation Products And Raw materials

Raw materials

2,5-Dimethyl pyrazine N-oxide

Preparation Products

isopentyldimethylpyrazine,2-isopentyl-3,6-dimethylpyrazine 4-Chloro-2,6-dimethylpyrimidine 3-iodo-2,5-diMethylpyrazine

3-Chloro-2,5-dimethylpyrazine Suppliers

Global( 210)Suppliers
Supplier Tel Email Country ProdList Advantage
Lanzhou Kangyuxin Biotechnology Co., Ltd. 0943-8293106 sales@kyxpharma.com China 3552 58
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13774476675 sales@fdc-chemical.com China 10000 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Changzhou Huanling Chemical Co., Ltd. 89803005 18206112582 info@huanlingchem.com China 983 68
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Supplier Advantage
Lanzhou Kangyuxin Biotechnology Co., Ltd. 58
SHANGHAI FDC-CHEMICAL CO.,LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Changzhou Huanling Chemical Co., Ltd. 68
Pure Chemistry Scientific Inc. 62

View Lastest Price from 3-Chloro-2,5-dimethylpyrazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-CHLORO-2,5-DIMETHYLPYRAZINE pictures 2026-08-20 3-CHLORO-2,5-DIMETHYLPYRAZINE
95-89-6
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
3-CHLORO-2,5-DIMETHYLPYRAZINE pictures 2026-03-20 3-CHLORO-2,5-DIMETHYLPYRAZINE
95-89-6
 $9.90 1KG 99% 5tons Hebei Chuanghai Biotechnology Co., Ltd
3-CHLORO-2,5-DIMETHYLPYRAZINE pictures 2025-05-26 3-CHLORO-2,5-DIMETHYLPYRAZINE
95-89-6
 $5.00 1kg 0.99 10000 Hebei Fengjia New Material Co., Ltd

3-Chloro-2,5-dimethylpyrazine Spectrum

3-CHLORO-2,5-DIMETHYLPYRAZINE(95-89-6)1HNMR3-CHLORO-2,5-DIMETHYLPYRAZINE(95-89-6)Raman3-CHLORO-2,5-DIMETHYLPYRAZINE(95-89-6)IR3-CHLORO-2,5-DIMETHYLPYRAZINE(95-89-6)FT-IR

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Pyrazine, 3-chloro-2,5-dimethyl- 3-CHLORO-2,5-DIMETHYL-1,4-DIAZINE 3-CHLORO-2,5-DIMETHYLPIAZINE 3-Chloro-2,5-diMethylpyrazine, 97+% 3-Chloro-2,5-diMethylpyrazine 98% 3-Chloro-2,5-dimethylpyrazine > 3-CHLORO-2,5-DIMETHYLPYRAZINE ISO 9001：2015 REACH 3-Chloro-2,5-dimethylpyrazine,93% 2,5-Dimethyl-3-chloropyrazine 3-Chloro-2,5-dimethylpyrazine 95-89-6 Pyrazines Mono- & Polyalkylpyrazines HETERO CHLORIDE Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Mono- & Polyalkylpyrazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrazinesHeterocyclic Building Blocks Pyrazines