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2,4-Difluoronitrobenzene

2,4-Difluoronitrobenzene Structure
2,4-Difluoronitrobenzene structure
CAS No.
446-35-5
Chemical Name:
2,4-Difluoronitrobenzene
Synonyms
2,4-DIFLUORO-1-NITROBENZENE;2.4 DFNB;2,4-Difluoronitroben;3,5-diflurobenzonitrile;2,4-Difluronitrobenzene;2,4-Difluoronitribenzene;2,4-DIFLUORO NITROBENZEN;2,4-DIFLUORONITROBENZENE;Flurbiprofen Impurity 24;1,3-Difluor-4-nitrobenzol
CBNumber:
CB0722917
Molecular Formula:
C6H3F2NO2
Molecular Weight:
159.09
MDL Number:
MFCD00007050
MOL File:
446-35-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:51:47
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2,4-Difluoronitrobenzene Properties

Melting point 9-10 °C (lit.)
Boiling point 203-204 °C (lit.)
Density 1.451 g/mL at 25 °C (lit.)
vapor density >1 (vs air)
refractive index n20/D 1.511(lit.)
Flash point 195 °F
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Light yellow to Brown
Specific Gravity 1.45
Water Solubility Insoluble in water.
BRN 2048034
Stability Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
InChI 1S/C6H3F2NO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H
InChIKey RJXOVESYJFXCGI-UHFFFAOYSA-N
SMILES [O-][N+](=O)c1ccc(F)cc1F
CAS DataBase Reference 446-35-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 6398Y1D7JS
NIST Chemistry Reference 2,4-Difluoronitrobenzene(446-35-5)
EPA Substance Registry System 2,4-Difluoronitrobenzene (446-35-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P301+P310+P330-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  T,Xi,Xn
Risk Statements  25-36/37/38-23/24/25-20/21/22
Safety Statements  26-45-36/37/39-23
RIDADR  UN 2810 6.1/PG 1
WGK Germany  3
RTECS  CZ5730000
Hazard Note  Irritant
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29049090
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

2,4-Difluoronitrobenzene price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 233226 2,4-Difluoronitrobenzene 99% 446-35-5 25g $36.8 2026-04-30 Buy
Sigma-Aldrich 233226 2,4-Difluoronitrobenzene 99% 446-35-5 100g $135 2026-04-30 Buy
TCI Chemical D1636 2,4-Difluoronitrobenzene >99.0%(GC) 446-35-5 25g $27 2026-04-30 Buy
TCI Chemical D1636 2,4-Difluoronitrobenzene >99.0%(GC) 446-35-5 500g $169 2026-04-30 Buy
Biosynth FD64613 2,4-Difluoronitrobenzene 446-35-5 1kg $900 2026-06-04 Buy
Product number Packaging Price Buy
233226 25g $36.8 Buy
233226 100g $135 Buy
D1636 25g $27 Buy
D1636 500g $169 Buy
FD64613 1kg $900 Buy

2,4-Difluoronitrobenzene Chemical Properties,Uses,Production

Synthesis

KF with n-Hexadecyltrimethylammonium bromide as the PTC has been shown recently to work in dimethylformamide (DMF), important owing to the low cost16 of DMF.Synthesis of 2,4-Difluoronitrobenzene

Chemical Properties

yellow liquid

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of:

  • 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction
  • (±)-horsfiline
  • resin-bound 2-arylaminobenzimidazoles

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of: 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction; (±)-horsfiline; resin-bound 2-arylaminobenzimidazoles.
2,4-Difluoronitrobenzene is a reactant in the preparation of 4-thiazolidinone derivatives as antimicrobial agents.

General Description

Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.

References

[1] Catalysis Today, 2012, vol. 198, # 1, p. 300 - 304
[2] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 8
[3] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 7-9
[4] Tetrahedron, 1995, vol. 51, # 22, p. 6363 - 6376
[5] Journal of the American Chemical Society, 1956, vol. 78, p. 6034,6037

2,4-Difluoronitrobenzene Preparation Products And Raw materials

Raw materials

1,3-Difluorobenzene tetrakis(N,N-DIethylaMino)phosphorus broMide Tetrabutylphosphonium bromide Potassium fluoride Trihexyl(tetradecyl)phosphonium tetrafluoroborate
Dimethyl sulfoxide 2,4-Dichloronitrobenzene

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Preparation Products

5-Fluoro-2-oxindole 2,4-Difluoroaniline 3-Fluoro-4-nitroanisole 3-Fluoro-4-nitroaniline 1,5-Difluoro-2,4-dinitrobenzene
2,6-Difluoronitrobenzene 2-Chloro-4-fluoronitrobenzene 1-Fluoro-3-nitrobenzene

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2,4-Difluoronitrobenzene Suppliers

Global( 516)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 13396369453 18678026865 sdfantai@163.com China 904 58
Shandong Xibang Biological Technology Development Co. LTD 0536-3611186 15063661551 196056703@qq.com China 58 58
Weifang Siyuan Chemical Co., Ltd. 0536-8888106 17663601818 2354379876@qq.com China 244 58
Yancheng Green Fluorine Fine Chemical Trading Co., Ltd 17887358129 lvfu@163.cn China 40 58
Zhejiang Xieshi New Materials Co., Ltd., 17858121723 sales09@xieshichem.com China 191 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Supplier Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
Shandong Xibang Biological Technology Development Co. LTD 58
Weifang Siyuan Chemical Co., Ltd. 58
Yancheng Green Fluorine Fine Chemical Trading Co., Ltd 58
Zhejiang Xieshi New Materials Co., Ltd., 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56

View Lastest Price from 2,4-Difluoronitrobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Difluoronitrobenzene pictures 2026-09-02 2,4-Difluoronitrobenzene
446-35-5
 $9.00 1KG 99% Henan Fengda Chemical Co., Ltd
2,4-Difluoronitrobenzene pictures 2026-06-30 2,4-Difluoronitrobenzene
446-35-5
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
2,4-Difluoronitrobenzene pictures 2026-05-28 2,4-Difluoronitrobenzene
446-35-5
 $10.00 1KG 99.% 10 ton Hebei Chuanghai Biotechnology Co,.LTD

2,4-Difluoronitrobenzene Spectrum

2,4-Difluoronitrobenzene(446-35-5)MS2,4-Difluoronitrobenzene(446-35-5)1HNMR2,4-Difluoronitrobenzene(446-35-5)13CNMR2,4-Difluoronitrobenzene(446-35-5)IR12,4-Difluoronitrobenzene(446-35-5)Raman

446-35-5(2,4-Difluoronitrobenzene)Related Search:

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1,3-difluoro-4-nitrobenzene 1-Nitro-2,4-difluorobenzene 2,4-difluoro-1-nitro-benzen 2,4-Difluronitrobenzene Benzene, 2,4-difluoro-1-nitro- 2,4-DIFLUORONITROBENZENE 2,4-DIFLUORO NITROBENZEN 2,4-Difluoronitribenzene Benzene, 2,4-difluoro-1-nitro- (6CI,7CI,8CI,9CI) 3,5-diflurobenzonitrile 2,4-DIFLUORONITROBENZENE =99%(HPLC) 2,4-Difluoronitroben 2.4 DFNB 2,4-Difluoronitrobenzene14 2, 4-2 fluoro nitrobenzene 2,4-Difluoronitrobenzene99% 1,3-Difluor-4-nitrobenzol 2,4-Difluoronitrobenzene> 2,4-Difluoronitrobenzene,>98% Flurbiprofen Impurity 24 2,4-Difluoronitrobenzene ISO 9001：2015 REACH 4-flouro-3-nitrobenzene sulfonic acid potassium salt high quality 2,4-Difluoronitrobenzene 2,4-Difluoronitrobenzene extrapure, 99% 2,4- Di Fluoro Nitro Benzene (2,4 DFNB) 2,4-Difluoro-1-nitrobenzene, 98% 2,4-DIFLUORO-1-NITROBENZENE 446-35-5 F2C6H3NO2 Building Blocks Nitro Compounds Organic Building Blocks Nitrogen Compounds Fluorine series alkyl Fluorine| nitro-compound HALIDE Aromatic Hydrocarbons (substituted) & Derivatives