4-Nitroanisole
- CAS No.
- 100-17-4
- Chemical Name:
- 4-Nitroanisole
- Synonyms
- 1-METHOXY-4-NITROBENZENE;Nitroanisole;4-Nitroanisol;p-Nitroanisol;PARA-NITROANISOLE;4-Nitroanisole,98%;p-nitro-anisol;4-NITROANISOLE;P-NITROANISOLE;Anisole, p-nitro-
- CBNumber:
- CB0182966
- Molecular Formula:
- C7H7NO3
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD00007327
- MOL File:
- 100-17-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Nitroanisole 97% | 103543 | 5g | $35.8 |
| 4-Nitroanisole 97% | 103543 | 25g | $63.1 |
| 4-Nitroanisole >98.0%(GC) | N0126 | 25g | $23 |
| 4-Nitroanisole >98.0%(GC) | N0126 | 100g | $48 |
| 4-Nitroanisole ≥95% | OR6596 | 1g | $21 |
| More product size | |||
| Melting point | 51-53 °C |
|---|---|
| Boiling point | 260 °C |
| Density | 1.233 g/mL at 25 °C(lit.) |
| refractive index | 1.5030 (estimate) |
| Flash point | 130 °C |
| form | Crystals |
| Specific Gravity | 1.233 |
| color | Green to brown |
| Water Solubility | 0.468 g/L (20 ºC) |
| Merck | 14,6584 |
| BRN | 1865361 |
| Henry's Law Constant | 5.0×100 mol/(m3Pa) at 25℃, Ebert et al. (2023) |
| Dielectric constant | 24.0（20℃） |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| InChI | 1S/C7H7NO3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3 |
| InChIKey | BNUHAJGCKIQFGE-UHFFFAOYSA-N |
| SMILES | COc1ccc(cc1)[N+]([O-])=O |
| CAS DataBase Reference | 100-17-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | G989Z7WOLH |
| Proposition 65 List | Para-Nitroanisole |
| NIST Chemistry Reference | Benzene, 1-methoxy-4-nitro-(100-17-4) |
| IARC | 2B (Vol. 123) 2020 |
| EPA Substance Registry System | p-Nitroanisole (100-17-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H351-H412 | |||||||||
| Precautionary statements | P202-P273-P280-P308+P313-P405-P501 | |||||||||
| PPE | Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 52/53-68 | |||||||||
| Safety Statements | 61-36/37 | |||||||||
| RIDADR | UN 2730 6.1/PG III (NITROANISOLES, LIQUID) | |||||||||
| RIDADR | UN 3458 6.1/PG III (NITROANISOLES, SOLID) | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | BZ8800000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29093090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Aquatic Chronic 3 Carc. 2 |
|||||||||
| NFPA 704 |
|
4-Nitroanisole price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 103543 | 4-Nitroanisole 97% | 100-17-4 | 5g | $35.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 103543 | 4-Nitroanisole 97% | 100-17-4 | 25g | $63.1 | 2026-04-30 | Buy |
| TCI Chemical | N0126 | 4-Nitroanisole >98.0%(GC) | 100-17-4 | 25g | $23 | 2026-04-30 | Buy |
| TCI Chemical | N0126 | 4-Nitroanisole >98.0%(GC) | 100-17-4 | 100g | $48 | 2026-04-30 | Buy |
| Apolloscientific | OR6596 | 4-Nitroanisole ≥95% | 100-17-4 | 1g | $21 | 2026-06-04 | Buy |
4-Nitroanisole Chemical Properties,Uses,Production
Chemical Properties
beige crystalline solid. soluble in alcohol, ether and boiling petroleum ether, slightly soluble in cold petroleum ether, insoluble in water.
Uses
o-Isomer as dye intermediate; in organic syntheses.
Uses
4-Nitroanisole is an intermediate in the manufacture of azo dyes. A toxic organic pollutant and a risk factor for urinary bladder cancer in humans.
Preparation
Produced from p-nitrochlorobenzene by methoxylation.
Definition
ChEBI: 4-nitroanisole is a member of the class of 4-nitroanisoles that is anisole in which one the hydrogen meta to the methoxy group is replaced by a nitro group.
Synthesis Reference(s)
Synthetic Communications, 25, p. 1367, 1995 DOI: 10.1080/00397919508013838
Tetrahedron Letters, 14, p. 1397, 1973
General Description
A light red or amber-colored liquid or crystals. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation or skin absorption. Used to make other chemicals.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4-Nitroanisole reacts explosively with (sodium hydroxide + zinc). 4-Nitroanisole reacts vigorously with hydrogen + catalyst (at 482° F and 25500 mm Hg).
Health Hazard
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Biochem/physiol Actions
4-Nitroanisole is O-demethylated to 4-nitrophenol by human liver microsomes.
Safety Profile
A poison by ingestion. Mutation data reported. Can explode in presence of Ni. When heated to decomposition it emits toxic fumes of NOx. See also o-NITROANISOLE and NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.
Purification Methods
Crystallise it from pet ether or hexane and dry it in vacuo. [Beilstein 6 IV 1282.]
4-Nitroanisole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43414 | 58 |
| Shanghai Xinchem | +86-021-64606569 +8618049800532 | xinchem@vip.126.com | China | 2918 | 58 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11705 | 57 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13350 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
| Chengdu Huachun Technology Co., Ltd | 400-1166-196 15982826727 | cdhxsj@163.com | China | 14603 | 60 |
| Rhawn Reagent | 400-400-1332688 18019345275 | huyue@rhawn.cn | China | 14948 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 6206333 13167063860 | anhua.mao@aladdin-e.com | China | 49998 | 58 |
| Shanghai Baoyang Baoxin Biotechnology Co., LTD | 021-56698539 19921169802 | bxsw_sh@163.com | China | 3917 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-5885952 15955137747 | sales@aikonchem.com | China | 8014 | 58 |
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