2-Nitroanisole
- CAS No.
- 91-23-6
- Chemical Name:
- 2-Nitroanisole
- Synonyms
- 1-METHOXY-2-NITROBENZENE;NCI-C60388;2-NITROANISOL;2-NITROANISOLE;O-NITROANISOLE;o-nitro-anisol;Anisole, o-nitro-;2-Nitroanisole>ORTHO-NITROANISOLE;ANISOLE,ORTHO-NITRO
- CBNumber:
- CB1101492
- Molecular Formula:
- C7H7NO3
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD00007096
- MOL File:
- 91-23-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Nitroanisole ≥99% | 236284 | 100g | $69.8 |
| 2-Nitroanisole >98.0%(GC) | N0125 | 25g | $58 |
| 2-Nitroanisole >98.0%(GC) | N0125 | 500g | $190 |
| 2-Nitroanisole | TRC-N491950-25G | 25g | $133 |
| 2-Nitroanisole | TRC-N491950-1G | 1g | $91 |
| More product size | |||
| Melting point | 9-12 °C (lit.) |
|---|---|
| Boiling point | 273 °C (lit.) |
| Density | 1.254 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Refrigerator, Under Inert Atmosphere |
| solubility | alcohol: soluble(lit.) |
| form | Oil |
| color | Pale Yellow |
| Specific Gravity | 1.254 |
| Water Solubility | 1.45 g/L (20 ºC) |
| Merck | 14,6584 |
| BRN | 1868032 |
| Henry's Law Constant | 2.3×101 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Dielectric constant | 43.0 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C7H7NO3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3 |
| InChIKey | CFBYEGUGFPZCNF-UHFFFAOYSA-N |
| SMILES | COc1ccccc1[N+]([O-])=O |
| Toxicology and Carcinogenesis | Toxicology and Carcinogenesis Studies of o-Nitroanisole (CASRN 91-23-6) in F344 Rats and B6C3F1 Mice (Feed Studies) |
| CAS DataBase Reference | 91-23-6(CAS DataBase Reference) |
| EWG's Food Scores | 3 |
| FDA UNII | ZRE7HLZ17K |
| Proposition 65 List | o-Nitroanisole |
| IARC | 2A (Vol. 65, 127) |
| NIST Chemistry Reference | Benzene, 1-methoxy-2-nitro-(91-23-6) |
| EPA Substance Registry System | o-Nitroanisole (91-23-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H350 | |||||||||
| Precautionary statements | P201-P301+P312+P330-P308+P313 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-22 | |||||||||
| Safety Statements | 53-45 | |||||||||
| RIDADR | UN 2730 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BZ8790000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29093090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 4 Oral Carc. 1B |
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| Hazardous Substances Data | 91-23-6(Hazardous Substances Data) | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Nitroanisole price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 236284 | 2-Nitroanisole ≥99% | 91-23-6 | 100g | $69.8 | 2026-04-30 | Buy |
| TCI Chemical | N0125 | 2-Nitroanisole >98.0%(GC) | 91-23-6 | 25g | $58 | 2026-04-30 | Buy |
| TCI Chemical | N0125 | 2-Nitroanisole >98.0%(GC) | 91-23-6 | 500g | $190 | 2026-04-30 | Buy |
| TRC | TRC-N491950-25G | 2-Nitroanisole | 91-23-6 | 25g | $133 | 2026-06-03 | Buy |
| TRC | TRC-N491950-1G | 2-Nitroanisole | 91-23-6 | 1g | $91 | 2026-06-03 | Buy |
2-Nitroanisole Chemical Properties,Uses,Production
Chemical Properties
yellow to amber liquid
Chemical Properties
2-Nitroanisole is a yellowish or light-red to amber liquid. May be transported in molten form.
Uses
2-Nitroanisole is an intermediate in the synthesis of various potential therapeutic compounds.
Uses
2-Nitroanisole has been employed as solvatochromic probe to examine cybotactic region of pure and mixed supercritical fluid solvent systems.
Production Methods
Methanolic sodium hydroxide is added slowly to a solution of 2- chloronitrobenzene in methanol at 70 ℃; the mixture is then heated gradually to 95 ℃ under pressure to complete the reaction. After dilution with water the product 2-Nitroanisole is separated as an oil, in 90 % yield, and methanol is recovered from the aqueous layer.
Definition
ChEBI: A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 4501, 1988 DOI: 10.1016/S0040-4039(00)80531-6
General Description
2-Nitroanisole (2-methoxynitrobenzene is an industrial and environmental pollutant causing tumors of the urinary bladder in rats and mice. Tumorigenic potential of 2-nitroanisole has been evaluated by host-mediated in vitro and in vivo assay.
Hazard
Questionable carcinogen.
Safety Profile
Confirmed carcinogen. Moderately toxic by ingestion. Mutation data reported. Explosive reaction with sodium hydroxide + zinc. Vigorous reaction with hydrogen + catalyst (at 250°C/34bar). When heated to decomposition it emits toxic fumes of NOx. See also p- NITROANISOLE.
Potential Exposure
A dye intermediate and for synthesis of other chemicals. NFPA has reported an explosion on during reduction with a nickel catalyst. Occupational exposure to 2-nitroanisole may occur through inhalation and dermal contact with this compound at workplaces where the chemical is produced or used.
Carcinogenicity
o-Nitroanisole is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
Shipping
UN2730 Nitroanisoles, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3458 Nitroanisoles, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Purify it by repeated vacuum distillation in the absence of oxygen. [Beilstein 6 IV 1249.]
Incompatibilities
A strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Explodes at temperatures ＞110℃. Combustible-liquid or fine powder may form explosive mixture with air. Nitroanisole reacts explosively with (sodium hydroxide ＋ zinc). It reacts vigorously with hydrogen1 catalyst (@ 250℃ & 25,500 mmHg).
Waste Disposal
Use a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
2-Nitroanisole Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9984 | 58 |
| CD Chemical Group Limited | +86-13651442114 | info@codchem.com | China | 17253 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +86-15195660023 | 3899766280@qq.com | China | 26349 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43392 | 58 |
| Shanghai Xinchem | +86-021-64606569 +86-18049800532 | xinchem@vip.126.com | China | 2916 | 58 |
| XIAMEN EQUATION CHEMICAL CO.,LTD | +86-5926515854 +86-18060954864 | sales@equationchemical.com | China | 2998 | 58 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2779 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 | sales@mreda.com.cn | China | 19323 | 58 |
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