4-Biphenylacetic acid
- CAS No.
- 5728-52-9
- Chemical Name:
- 4-Biphenylacetic acid
- Synonyms
- FELBINAC;2-([1,1'-biphenyl]-4-yl)acetic acid;Napageln;BIPHENYL-4-ACETIC ACID;[1,1'-BIPHENYL]-4-ACETIC ACID;L-141;TraxaM;LY-61017;Seltouch;CI 83544
- CBNumber:
- CB0186272
- Molecular Formula:
- C14H12O2
- Molecular Weight:
- 212.24
- MDL Number:
- MFCD00004351
- MOL File:
- 5728-52-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Felbinac European Pharmacopoeia (EP) Reference Standard | Y0000731 | 10 mg | $170 |
| 4-Biphenylacetic acid 98% | 196487 | 5g | $66.1 |
| 4-Biphenylacetic acid 98% | 196487 | 25g | $120 |
| 4-Biphenylacetic Acid >98.0%(HPLC)(T) | B1278 | 25g | $35 |
| 4-Biphenylacetic Acid >98.0%(HPLC)(T) | B1278 | 250g | $197 |
| More product size | |||
| Melting point | 159-160 °C (lit.) |
|---|---|
| Boiling point | 312.08°C (rough estimate) |
| Density | 1.1035 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble50mg/mL, clear, colorless to yellow |
| pka | 4.29±0.10(Predicted) |
| form | Powder |
| color | Beige |
| Water Solubility | 39.27mg/L(25 ºC) |
| Merck | 14,3316 |
| BRN | 1211592 |
| InChI | InChI=1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16) |
| InChIKey | QRZAKQDHEVVFRX-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=CC=C2)=CC=C(CC(O)=O)C=C1 |
| CAS DataBase Reference | 5728-52-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 94WNJ5U8L7 |
| ATC code | M02AA08 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H331-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P301+P310-P302+P352-P304+P340+P311-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 23/25-36/37/38-25-36/37/38/63-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-45-37/39-28A-26/36/3745/60-20-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DU8229050 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29163900 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Inhalation Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Toxicity | LD50 orally in rats: 164 mg/kg (Sloboda, Osterberg) | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Biphenylacetic acid price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000731 | Felbinac European Pharmacopoeia (EP) Reference Standard | 5728-52-9 | 10 mg | $170 | 2026-04-30 | Buy |
| Sigma-Aldrich | 196487 | 4-Biphenylacetic acid 98% | 5728-52-9 | 5g | $66.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 196487 | 4-Biphenylacetic acid 98% | 5728-52-9 | 25g | $120 | 2023-01-07 | Buy |
| TCI Chemical | B1278 | 4-Biphenylacetic Acid >98.0%(HPLC)(T) | 5728-52-9 | 25g | $35 | 2026-04-30 | Buy |
| TCI Chemical | B1278 | 4-Biphenylacetic Acid >98.0%(HPLC)(T) | 5728-52-9 | 250g | $197 | 2026-04-30 | Buy |
4-Biphenylacetic acid Chemical Properties,Uses,Production
Description
Felbinac Is the active metabolite of the non-steroidal antiinflammatory agent, fenbufen. Applied topically as a gel to joints, it is useful in the symptomatic relief of articular inflammation and pain.
Chemical Properties
Off-white powder
Originator
Lederle (USA)
Uses
Anti-inflammatory, analgesic drug.
Uses
4-Biphenylacetic acid was used in the synthesis of gastrosparing non-steroidal antiinflammatory drug.
Definition
ChEBI: Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It is functionally related to an acetic acid.
brand name
Dolinac (Wyeth-Ayerst); Flexfree(Wyeth-Ayerst); Napageln (Wyeth-Ayerst); Target (Wyeth-Ayerst); Traxam (Wyeth-Ayerst).
General Description
4-Biphenylacetic acid is a potential non-steroidal antiinflammatory agent and forms solid inclusion complex with β-cyclodextrin. 4-Biphenylacetic acid on interaction with quinolone antibacterial agents induces functional blockade of the γ-aminobutyric acid receptors.
Safety Profile
Poison by subcutaneous route.Moderately toxic by ingestion and intraperitoneal routes.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits acrid smoke and fumes.
Synthesis
First 4-aminophenylacetic acid is prepared by reducing 4-nitrophenylacetic acid in the presence of a palladium-carbon catalyst; 4-Biphenylacetic acid is finally prepared by reacting 4-aminophenylacetic acid with benzene in the presence of sodium nitrite and an acid.
4-Biphenylacetic acid Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 906 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Dalian Richfortune Chemicals Co., Ltd | +86-86-411-84820922 +86-8613904096939 | sales@richfortunechem.com | China | 305 | 57 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
View Lastest Price from 4-Biphenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | 4-Biphenylacetic acid
5728-52-9
|
US $0.00 / KG | 1KG | 0.99 | 1000KG | Shaanxi Xianhe Biotech Co., Ltd | |
 |
2026-04-30 | 4-Biphenylacetic acid
5728-52-9
|
US $0.00-0.00 / Kg/Drum | 1KG | 99%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-04-27 | 4-Biphenylacetic acid
5728-52-9
|
US $0.00 / KG | 1KG | 0.99 | 20TONS | Taizhou Creating Bio-pharm co., ltd. |
-
- 4-Biphenylacetic acid
5728-52-9
- US $0.00 / KG
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- 4-Biphenylacetic acid
5728-52-9
- US $0.00-0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Biphenylacetic acid
5728-52-9
- US $0.00 / KG
- 0.99
- Taizhou Creating Bio-pharm co., ltd.
