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(R)-(+)-HA-966

(R)-(+)-HA-966 structure

CAS No.: 123931-04-4

Chemical Name:: (R)-(+)-HA-966

Synonyms: RMA-5;(+)-HA-966;HA966-001-R;Zinc03791818;(R)-(+)-HA-966;(R)(+)HA966,(R) (+) HA 966;R(+)-HA-966 R(+)-3-AMINO-1-HYDROX;(3R)-3-Amino-1-hydroxy-2-pyrrolidinone;R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE;(R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE

CBNumber:: CB0190556

Molecular Formula:: C4H8N2O2

Molecular Weight:: 116.12

MDL Number:: MFCD00078583

MOL File:: 123931-04-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:35

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(R)-(+)-HA-966 Properties

Melting point	166℃
Boiling point	258.6±50.0 °C(Predicted)
Density	1.436±0.06 g/cm3(Predicted)
storage temp.	Desiccate at RT
solubility	H₂O: soluble
form	solid
pka	7.19±0.20(Predicted)
color	white
optical activity	[α]22/D +103°, c = 1 in H2O(lit.)
Water Solubility	Soluble to 100 mM in water
InChI	1S/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2/t3-/m1/s1
InChIKey	HCKUBNLZMKAEIN-GSVOUGTGSA-N
SMILES	N[C@@H]1CCN(O)C1=O
FDA UNII	2N9Q4C7WMT
UNSPSC Code	12352111
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

(R)-(+)-HA-966 price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H130	R(+)-HA-966 solid	123931-04-4	5mg	$176	2026-04-30	Buy
Usbiological	463595	(R)-(+)-HA-966	123931-04-4	5mg	$389	2026-06-03	Buy
Usbiological	463595	(R)-(+)-HA-966	123931-04-4	10mg	$545	2026-06-03	Buy
ChemScene	CS-0020466	(R)-(+)-HA-966	123931-04-4	5mg	$81	2026-06-04	Buy
ChemScene	CS-0020466	(R)-(+)-HA-966	123931-04-4	10mg	$135	2026-06-04	Buy

Product number	Packaging	Price	Buy
H130	5mg	$176	Buy
463595	5mg	$389	Buy
463595	10mg	$545	Buy
CS-0020466	5mg	$81	Buy
CS-0020466	10mg	$135	Buy

(R)-(+)-HA-966 Chemical Properties, Uses, Production

Uses

(R)-(+)-HA-966 is an antagonist/partial agonist at the glycine site of the NMDA receptor.

Biological Activity

Antagonist/partial agonist at the glycine site of the NMDA receptor; able to cross the blood-brain barrier. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .

in vivo

(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.)^[3].
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g)^[1].

Animal Model:	Sprague-Dawley rats (11 to 12 weeks old)^[3]
Dosage:	10 mg/kg
Administration:	IV
Result:	Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA.

IC 50

NMDA Receptor

storage

Desiccate at RT

(R)-(+)-HA-966 Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(+)-HA-966 Suppliers

Global Suppliers ( 49)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7881	64
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8435	60
Zhengzhou AiXi Technology Co., Ltd.	0371-56787280 13137706083	m18539565376@163.com	China	999	55
XinYao(Shenzhen) Biological Technology Co., Ltd.	0755-89880280	3004662104@qq.com	China	1826	58
Jinan Yaoyan Pharmaceutical Co., Ltd.		jnyaoyan@163.com	China	3057	58
Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd.	0531-58897130 15508676053	drug_impurity@sdcclh.com	China	2526	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	meitaochem@126.com	meitaochem@126.com	China	19087	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Tetranov Biopharm	64
China DongFan Chemical Co.,LTD	66
EMMX Biotechnology LLC	60
Zhengzhou AiXi Technology Co., Ltd.	55
XinYao(Shenzhen) Biological Technology Co., Ltd.	58
Jinan Yaoyan Pharmaceutical Co., Ltd.	58
Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd.	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	58
BOC Sciences	58

123931-04-4 ((R)-(+)-HA-966) Related Search:

1H-Pyrrol-3-amine(9CI) 3-Amino-pyrrolidin-2-one (S)-(-)-3-Amino-1-hydroxypyrrolidin-2-one (+/-)-3-Amino-1-hydroxy-2-pyrrolidone Amino acid hydroxamates glycine hydroxamate

(+/-)-HA-966 (R)-3-Aminopyrrolidine (R)-(+)-HA-966

1of2

R(+)-HA-966 R(+)-3-AMINO-1-HYDROX (R)-(+)-HA-966 R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE (R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE Zinc03791818 (3R)-3-Amino-1-hydroxy-2-pyrrolidinone (R)-3-amino-1-hydroxypyrrolidin-2-one 2,2,2-trifluoroacetate 2-Pyrrolidinone, 3-amino-1-hydroxy-, (3R)- (+)-HA-966 HA966-001-R (R)(+)HA966,(R) (+) HA 966 RMA-5 123931-04-4 Ion Channels Ionotropic Glutamate Receptor Modulators Ligand-Gated Ion Channels Cell Biology Cell Signaling and Neuroscience BioChemical Glutamate receptor