1-(Bromomethyl)-3-phenoxybenzene
- CAS No.
- 51632-16-7
- Chemical Name:
- 1-(Bromomethyl)-3-phenoxybenzene
- Synonyms
- 3-Phenoxybromobenzyl;3-phenoxybenzylbromide;m-phenoxybenzylbromide;3-PHENYLOXYBENZYLBROMIDE;3-(Bromomethyl)diphenyl ether;1-(Bromomethyl)-3-phenoxybenzene;m-(bromomethyl)phenylphenylether;1-(bromomethyl)-3-phenoxy-benzen;Benzene, 1-(bromomethyl)-3-phenoxy-;[3-(Bromomethyl)phenyl]phenyl ether
- CBNumber:
- CB0208145
- Molecular Formula:
- C13H11BrO
- Molecular Weight:
- 263.13
- MDL Number:
- MFCD01761658
- MOL File:
- 51632-16-7.mol
- MSDS File:
- SDS
| Boiling point | 112 °C |
|---|---|
| Density | 1.3883 (rough estimate) |
| refractive index | 1.5130 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | liquid |
| color | clear colourless |
| CAS DataBase Reference | 51632-16-7 |
| FDA UNII | GD31X56Z15 |
| EPA Substance Registry System | 1-(Bromomethyl)-3-phenoxybenzene (51632-16-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 43 | |||||||||
| Safety Statements | 36/37 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2909303890 | |||||||||
| Toxicity | LD50 orl-rat: 2326 mg/kg NTIS** OTS0537681 | |||||||||
| NFPA 704 |
|
1-(Bromomethyl)-3-phenoxybenzene price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P2948 | 1-(Bromomethyl)-3-phenoxybenzene min. 98.0 % | 51632-16-7 | 1G | $137 | 2026-04-30 | Buy |
| TCI Chemical | P2948 | 1-(Bromomethyl)-3-phenoxybenzene min. 98.0 % | 51632-16-7 | 5G | $410 | 2026-04-30 | Buy |
| Apolloscientific | OR12353 | 3-(Bromomethyl)diphenyl ether 97% | 51632-16-7 | 250mg | $59 | 2026-06-04 | Buy |
| Apolloscientific | OR12353 | 3-(Bromomethyl)diphenyl ether 97% | 51632-16-7 | 1g | $94 | 2026-06-04 | Buy |
| Apolloscientific | OR12353 | 3-(Bromomethyl)diphenyl ether 97% | 51632-16-7 | 5g | $293 | 2026-06-04 | Buy |
1-(Bromomethyl)-3-phenoxybenzene Chemical Properties, Uses, Production
Uses
1-(Bromomethyl)-3-phenoxybenzene-d5 is an intermediate in the synthesis of Etofenprox-phenol-d5 (E936401) which is a labelled form of Etofenprox (E936400), which is a pyrethroid derivative which is used as an insecticide. Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).
Safety Profile
Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of Brí.
Synthesis
13826-35-2
51632-16-7
General procedure for the synthesis of m-phenoxybenzyl bromide from 3-phenoxybenzyl alcohol: 3-phenoxybenzyl alcohol (2.09 g, 10.0 mmol) was dissolved in 18.7 mL of anhydrous dichloromethane and cooled to 0 °C. Subsequently, a solution of phosphorus tribromide (0.35 mL, 3.80 mmol) in 4.7 mL of dichloromethane was slowly added. The reaction mixture was naturally warmed to room temperature with continuous stirring for 30 minutes. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate and extracted with ether. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. Finally, purification by fast chromatography (eluent: hexane/ethyl acetate, 8:2) afforded 1.98 g of the target product, m-phenoxybenzyl bromide, as a colorless oil in 72% yield. The spectral data of the product were in agreement with those reported in the literature (Surman, MD; Mulvihill, MJ J. Org. Chem. 2002, 67, 4115-4121).
References
[1] Archiv der Pharmazie, 1983, vol. 316, # 7, p. 598 - 608
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 8, p. 3389 - 3395
[3] Patent: WO2008/110583, 2008, A1. Location in patent: Page/Page column 60
[4] Tetrahedron Letters, 1985, vol. 26, # 32, p. 3863 - 3866
[5] Journal of Organic Chemistry, 2002, vol. 67, # 12, p. 4115 - 4121
1-(Bromomethyl)-3-phenoxybenzene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 1999 | 58 |
| Shanghai Na Qian Chemical Technology Co. Ltd. | 13598610367 13598610367 | 2841375912@qq.com | China | 3774 | 52 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
