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N-Boc-4-iodopiperidine

N-Boc-4-iodopiperidine Structure
N-Boc-4-iodopiperidine structure
CAS No.
301673-14-3
Chemical Name:
N-Boc-4-iodopiperidine
Synonyms
tert-butyl 4-iodopiperidine-1-carboxylate;1-Boc-4-iodopiperidine;N-Boc-iodopiperidine;-Boc-4-iodopiperidine;N-BOC-4-IODO-PIPERIDINE;1-Boc-4-iodopiperidine,95%;1-Boc-4-Iodo-Piperidine,97%;4-Iodopiperidine, N-BOC protected;4-Iodopiperidine, N-BOC protected 97%;ert-butyl4-iodopiperidine-1-carboxylate
CBNumber:
CB1246852
Molecular Formula:
C10H18INO2
Molecular Weight:
311.16
MDL Number:
MFCD04115041
MOL File:
301673-14-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-02 13:17:11
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N-Boc-4-iodopiperidine Properties

Melting point 35-38°
Boiling point 318.8±35.0 °C(Predicted)
Density 1.50±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
pka -2.54±0.40(Predicted)
form Crystalline Powder or Low Melting Solid
color White to pale brown
Water Solubility Slightly soluble in water. Soluble in methanol.
Sensitive Light Sensitive
InChI InChI=1S/C10H18INO2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7H2,1-3H3
InChIKey YFWQFKUQVJNPKP-UHFFFAOYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC(I)CC1
CAS DataBase Reference 301673-14-3
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  22-26-36/37/39
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  29389090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
1
2 1

N-Boc-4-iodopiperidine price More Price(85)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B4164 1-tert-Butoxycarbonyl-4-iodopiperidine >97.0%(GC) 301673-14-3 1g $31 2026-04-30 Buy
TCI Chemical B4164 1-tert-Butoxycarbonyl-4-iodopiperidine >97.0%(GC) 301673-14-3 5g $86 2026-04-30 Buy
Usbiological 265897 N-Boc-4-iodo-piperidine Asreported 301673-14-3 2g $363 2026-06-03 Buy
Usbiological 265897 N-Boc-4-iodo-piperidine Asreported 301673-14-3 5g $503 2026-06-03 Buy
Usbiological 265897 N-Boc-4-iodo-piperidine Asreported 301673-14-3 10g $685 2026-06-03 Buy
Product number Packaging Price Buy
B4164 1g $31 Buy
B4164 5g $86 Buy
265897 2g $363 Buy
265897 5g $503 Buy
265897 10g $685 Buy

N-Boc-4-iodopiperidine Chemical Properties, Uses, Production

Chemical Properties

White powder

Uses

Used in the coupling reaction in Iron-and Cobalt-Catalyzed Arylation of Azetidines, Pyrrolidines, and Piperidines with Grignard Reagents.

Synthesis

N-BOC-4-Hydroxypiperidine

109384-19-2

N-Boc-4-iodopiperidine

301673-14-3

The general procedure for the synthesis of N-Boc-4-iodopiperidine from N-Boc-4-hydroxypiperidine was as follows: to a solution of N-Boc-4-hydroxypiperidine (10.0 g, 49.7 mmol) in dichloromethane (200 mL) was added triphenylphosphine (16.9 g, 64.6 mmol) and imidazole (5.07 g, 74.5 mmol) sequentially. After the reaction mixture was cooled to 0°C in an ice bath, iodine (15.1 g, 59.6 mmol) was added slowly in portions. After addition, the reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was diluted with water and extracted with ether. The organic layers were combined, washed sequentially with water and saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was ground with hexane to remove excess triphenylphosphine and triphenylphosphine oxide. After filtration, the filtrate was concentrated under reduced pressure to afford the target product N-Boc-4-iodopiperidine as a colorless oil (14.4 g, 93% yield).

References

[1] Patent: US2005/9838, 2005, A1. Location in patent: Page 143
[2] Patent: WO2018/106636, 2018, A1. Location in patent: Paragraph 00283
[3] Patent: WO2011/143366, 2011, A1. Location in patent: Page/Page column 45
[4] Journal of Organic Chemistry, 2004, vol. 69, # 15, p. 5120 - 5123
[5] Synlett, 1998, # 4, p. 379 - 380

N-Boc-4-iodopiperidine synthesis

109384-19-2
301673-14-3
Synthesis of N-Boc-4-iodopiperidine from N-BOC-4-Hydroxypiperidine

N-Boc-4-iodopiperidine Preparation Products And Raw materials

Raw materials

Imidazole N-BOC-piperidine-4-carboxylic acid N-BOC-4-Hydroxypiperidine Dichloromethane Triphenylphosphine
iodine

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Preparation Products

tert-butyl 4-nitropiperidine-1-carboxylate 3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid 3-Phenyl-2-(piperidin-4-yl)pyridine hydrochloride

N-Boc-4-iodopiperidine Suppliers

Global Suppliers ( 211)
Supplier Tel Email Country ProdList Advantage
Shanghai Hobor Chemical Co., Ltd 13918007836 sales@hoborchem.com China 423 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Supplier Advantage
Shanghai Hobor Chemical Co., Ltd 60
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62

View Latest Price from N-Boc-4-iodopiperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Boc-4-iodopiperidine pictures 2026-07-02 N-Boc-4-iodopiperidine
301673-14-3
 1KG 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
N-Boc-4-iodopiperidine pictures 2019-07-06 N-Boc-4-iodopiperidine
301673-14-3
 $1.00 1KG 98% 500kg Career Henan Chemical Co

N-Boc-4-iodopiperidine Spectrum

N-Boc-4-iodopiperidine(301673-14-3)1HNMRN-Boc-4-iodopiperidine(301673-14-3)FT-IR

301673-14-3 (N-Boc-4-iodopiperidine) Related Search:

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N-BOC-4-IODO-PIPERIDINE 1-(TERT-BUTOXYCARBONYL)-4-IODOPIPERIDINE 4-Iodopiperidine-1-carboxylic acid tert-butyl ester tert-butyl 4-iodopiperidine-1-carboxylate(SALTDATA: FREE) N-Boc-iodopiperidine 1-(tert-Butoxycarbonyl)-4-iodopiperidine, tert-Butyl 4-iodopiperidine-1-carboxylate 4-Iodopiperidine, N-BOC protected 1-tert-Butoxycarbonyl-4-iodopiperidine 1-Piperidinecarboxylicacid, 4-iodo-, 1,1-dimethylethyl ester 1-Boc-4-iodopiperidine 1-Boc-4-Iodo-Piperidine,97% 4-Iodopiperidine, N-BOC protected 97% 1-tert-Butoxycarbonyl-4-iodopiperidine > 1-Boc-4-iodopiperidine,95% ert-butyl4-iodopiperidine-1-carboxylate 4-Iodo-1-piperidinecarboxylic Acid tert-Butyl Ester tert-Butyl 4-Iodo-1-piperidinecarboxylate Octanedioicacid,3,9-dioxo-,dimethylester Tert-Butyl 4-Iodopiperidine-1-Carboxylat -Boc-4-iodopiperidine tert-butyl 4-iodopiperidine-1-carboxylate 301673-14-3 C10H18INO2 pharmacetical Heterocyclic Building Blocks