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UTP

UTP Structure
UTP structure
CAS No.
63-39-8
Chemical Name:
UTP
Synonyms
UTP TRISODIUM SALT;URIDINE-5'-TRIPHOSPHATE TRISODIUM SALT;UTP-NA;UTP Sodium;Uridine 5'-triphosphate;Uridine 5'-(tetrahydrogen triphosphate);pppU;5’-utp;uteplex;UTP, 3NA
CBNumber:
CB0221667
Molecular Formula:
C9H15N2O15P3
Molecular Weight:
484.14
MDL Number:
MFCD00274571
MOL File:
63-39-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-20 15:44:42
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UTP Properties

Density 2.106±0.06 g/cm3(Predicted)
Flash point 113 °C
storage temp. Sealed in dry,2-8°C
solubility Easily soluble (water)
pka pK1:7.58 (25°C)
form liquid
color colorless
PH 7.0 ± 0.1
biological source yeast (Candida Utilis)
Water Solubility Water : ≥ 150 mg/mL (309.83 mM)
InChIKey PGAVKCOVUIYSFO-XVFCMESISA-N
SMILES C(OP(=O)(O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](O)[C@@H]1O
CAS DataBase Reference 63-39-8(CAS DataBase Reference)
FDA UNII UT0S826Z60
EPA Substance Registry System Uridine 5'-(tetrahydrogen triphosphate) (63-39-8)
UNSPSC Code 41106305
NACRES NA.52

SAFETY

Risk and Safety Statements

Hazard Codes  Xn
Risk Statements  20/21/22-68/20/21/22
Safety Statements  22-26-36
WGK Germany  1

UTP price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich U1006 Uridine 5′-triphosphate trisodium salt solution HPLC purified, aqueous solution for RNA polymerase transcription 63-39-8 25μmol $107.1 2026-04-30 Buy
ApexBio Technology K1048 UTP Solution (100 mM) 250uL $60 2026-05-06 Buy
ApexBio Technology K1048 UTP Solution (100 mM) 1mL $150 2026-05-06 Buy
aablocks AA00IB1R Uridine 5'-triphosphate >99% 63-39-8 10mg $198 2026-05-29 Buy
aablocks AA00IB1R Uridine 5'-triphosphate 97+% 63-39-8 100mg $300 2026-05-29 Buy
Product number Packaging Price Buy
U1006 25μmol $107.1 Buy
K1048 250uL $60 Buy
K1048 1mL $150 Buy
AA00IB1R 10mg $198 Buy
AA00IB1R 100mg $300 Buy

UTP Chemical Properties, Uses, Production

Description

Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

Occurrence

Uridine 5'-triphosphate is a natural product found in Helianthus tuberosus, Apis cerana, and other organisms with data available.

Uses

Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).

Definition

UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a pyrimidine ribonucleoside 5'-triphosphate and a uridine 5'-phosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).

Biochem/physiol Actions

P2Y receptor agonist

Pharmacokinetics

INS316 is a short-acting, aerosolized uridine 5-triphosphate (UTP) solution used as a diagnostic aid for lung cancer. INS316 appears to improve sputum expectoration mediated through the P2Y2 receptor, a nucleotide receptor expressed in human airway epithelial cells and some other tissues. UTP binding to the P2Y2 receptor triggers signal transduction that leads to chloride ion secretion, thereby resulting in mucociliary clearance of airway.

in vitro

Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K.

in vivo

Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes.

References

[1]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.
[2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.
[3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.
[4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5'-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.

UTP synthesis

58-96-8
63-39-8
Synthesis of UTP from Uridine

UTP Preparation Products And Raw materials

Raw materials

2',3'-O-(Methoxymethylene)uridine 727398-81-4 Uridine 5'-monophosphate 727399-01-1 Adenosine triphosphate
2′,3′-O-Isopropylideneuridine Uridine Dicyclohexylcarbodiimide

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Preparation Products

Uridine 5'-monophosphate guanosine 5'-(tetrahydrogen triphosphate) UDP UDP-alpha-D-N-acetylgalactosamine, disodium salt

UTP Suppliers

Global Suppliers ( 159)
Supplier Tel Email Country ProdList Advantage
Nanjing Vazyme Biotech Co.,Ltd. 18860415469 bd-marketingsupport@vazyme.com China 22 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6741 52
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Shanghai Meishui Chemical Technology Co., Ltd 021-60549325 18616193163 China 4518 56
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9331 58
Shanghai ACT chemical Limited 021-59904146 18001826933 sales@actchemical.com China 476 56
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 15221275939 shenlinxing@macklin.cn China 15775 55
Supplier Advantage
Nanjing Vazyme Biotech Co.,Ltd. 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Shanghai Hanhong Scientific Co.,Ltd. 64
XiaoGan ShenYuan ChemPharm co,ltd 52
Beijing HuaMeiHuLiBiological Chemical 58
MedChemexpress LLC 58
Shanghai Meishui Chemical Technology Co., Ltd 56
Finetech Industry Limited 58
Shanghai ACT chemical Limited 56
Shanghai Macklin Biochemical Co.,Ltd. 55

View Latest Price from UTP manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Uridine 5'-Triphosphate pictures 2023-04-04 Uridine 5'-Triphosphate
63-39-8
 1ml 99% 1000L per month Zhejiang Hengkang Pharmaceutical Co., Ltd.
UTP pictures 2021-08-12 UTP
63-39-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
UTP pictures 2019-08-30 UTP
63-39-8
 $1.00 1KG 98% 200kg Career Henan Chemical Co
  • UTP pictures
  • UTP
    63-39-8
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • UTP pictures
  • UTP
    63-39-8
  • $1.00
  • 98%
  • Career Henan Chemical Co

63-39-8 (UTP) Related Search:

Uridine Uridine-5'-triphosphoric acid trisodium salt Uridine 5'-(trihydrogen diphosphate) P'-(6-azido-6-deoxy-alpha-D-glucopyranosyl) ester UDP-alpha-D-galactose disodium salt UTP TRIS SALT
cytidine 3',5'-diphosphate Diquafosol Impurity 12 Diquafosol DUTP, 100MM SOLUTION uridine 5'-tetraphosphate
Diquafosol Impurity 10 UDPGA TRISODIUM SALT URIDINE-13C9, 15N2-5 TRIPHOSPHATE SODI U UDP Uridine-5'-diphosphate disodium salt
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5'-URIDYLATE TRIPHOSPHATE UTP, 3NA UTP-NA UTP, NA3H UTP SODIUM SALT URIDINE-5'-TRIPHOSPHATE NA3-SALT URIDINE-5'-TRIPHOSPHATE SODIUM URIDINE 5'-TRIPHOSPHATE SODIUM SALT URIDINE 5-TRIPHOSPHATE TRISODIUM URIDINE-5'-TRIPHOSPHORIC ACID, TRISODIUM 5’-utp uridine,5’-(tetrahydrogentriphosphate) uridine5’-triphosphoricacid uridinetriphosphate uteplex ({[(2S,3R,4S,5S)-5-(2,4-dioxo-1,2,3,4-tetrahydropyriMidin-1-yl)-3,4-dihydroxyoxolan-2-yl]Methyl phosphonato}oxy)(phosphonatooxy)phosphinate Uridine 5′-triphosphate trisodium salt solution Uracylic [[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid 5'-uridylate triphosphate (UTP) Uridine-5''-triphosphoric acid (and/or unspecified salts) Uridine 5μ-triphosphate solution trisodium salt pppU Urd-5'-P3 UTP .Free Acid Mix of 25 mM ATP, CTP, GTP and UTP Adenosine-5'-triphosphate, Sodium salt Uridine-5'-triphosphate Free acid UTP Solution (100mM) ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate triphosphoric acid 1-uridin-5'-yl ester UTP 200mM Tris Solution, GMP grade UTP 200mM Tris Solution UTP Sodium Solution,UltraNUcTM?NTPs N1-Me-pUTP 100mM Ammonium Solution UTP Solution (100mM)(acid form) UTP·3Na 100mM Uridine 5'-(tetrahydrogen triphosphate) Uridine 5'-triphosphate URIDINE-5'-TRIPHOSPHATE TRISODIUM SALT UTP Sodium UTP TRISODIUM SALT 63-39-8 C9H15N2O15P3 Nucleotides DNA / RNA Synthesis NTP Elisa Kit-plant ELISA Kit