6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione
![6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione Structure](CAS/GIF/135481-57-1.gif)
- CAS No.
- 135481-57-1
- Chemical Name:
- 6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione
- Synonyms
- NSC 525977;6-Benzyl-5,6,7,8-tetrahyd...;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H);6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-D...;6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidin-2,4(1H,3H)-dione;6-benzyl-1H,2H,3H,4H,5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-2,4-dione;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione;6-(phenylmethyl)-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-dione;6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione 95%
- CBNumber:
- CB0234065
- Molecular Formula:
- C14H15N3O2
- Molecular Weight:
- 257.29
- MDL Number:
- MFCD06657750
- MOL File:
- 135481-57-1.mol
- MSDS File:
- SDS
| Density | 1.33 |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| pka | 10.04±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C14H15N3O2/c18-13-11-9-17(8-10-4-2-1-3-5-10)7-6-12(11)15-14(19)16-13/h1-5H,6-9H2,(H2,15,16,18,19) |
| InChIKey | CTFWHSOMLHCMRJ-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(=O)C2CN(CC3=CC=CC=C3)CCC=2N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | SC2041 | 6-BENZYL-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE 95% | 135481-57-1 | 1G | $47 | 2026-04-30 | Buy |
| AstaTech | SC2041 | 6-BENZYL-5,6,7,8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE 95% | 135481-57-1 | 5G | $173 | 2026-04-30 | Buy |
| Biosynth | KFA48157 | 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione | 135481-57-1 | 5g | $354 | 2026-06-04 | Buy |
| Apolloscientific | OR302148 | 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione 97% | 135481-57-1 | 250mg | $29 | 2026-06-04 | Buy |
| Apolloscientific | OR302148 | 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione 97% | 135481-57-1 | 1g | $56 | 2026-06-04 | Buy |
6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione Chemical Properties, Uses, Production
Application
6-Benzyl-5,6,7,8-tetrahydro-1H-piperidino[4,3-D]2,4-diamyrimidinone can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development and chemical production processes.
Synthesis
41276-30-6
57-13-6
![6-BENZYL-5,6,7,8-TETRAHYDRO-1H-PYRIDO[4,3-D]PYRIMIDINE-2,4-DIONE](/CAS/GIF/135481-57-1.gif)
135481-57-1
GENERAL STEPS: Ethyl 1-benzyl-4-piperidone-3-carboxylate (10.0 g, 33.5 mmol) was dissolved in anhydrous ethanol (150.0 mL), followed by the sequential addition of urea (10.0 g, 167.0 mmol) and sodium methanol (22.7 g, 118.0 mmol). The reaction mixture was stirred under heated reflux conditions for 24 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the precipitated solid was collected by filtration. The resulting solid was suspended in deionized water, and the pH was adjusted to 6.0 by slowly adding 6.0 mol/L hydrochloric acid solution. After continued stirring at room temperature for 1 h, the crystals were separated by filtration and dried under vacuum to afford 6-phenylmethyl-5,6,7,8-tetrahydro-1H-piperidino[4,3-D]2,4-dihydropyrimidinone (6.5 g, 75% yield), which was ready to use in the subsequent reaction without further purification. subsequent reaction without further purification. Thin-layer chromatography (TLC) analysis: Rf = 0.1 (Expanding agent: ethyl acetate/methanol=5:1); Melting point: 293 °C; 1H NMR (300 MHz, CDCl3, δ ppm): 2.43-2.45 (m, 2H), 2.51-2.52 (m, 2H), 3.01 (s, 2H), 3.53 (s, 2H), 7.23- 7.41 (m, 5H). 7.41 (m, 5H), 10.21 (s, 1H), 11.01 (s, 1H).
References
[1] European Journal of Medicinal Chemistry, 2014, vol. 79, p. 399 - 412
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10498 - 10519
[3] Patent: EP1537879, 2005, A1. Location in patent: Page/Page column 61
[4] Patent: EP1547616, 2005, A1. Location in patent: Page/Page column 65
6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou rich Medicine Technical Co;Ltd | 15221533763 | suzhourich@163.com | China | 950 | 58 |
| DKMbiochem.Co. Ltd | 15901859516 | sales@DKMbiochem.com | China | 361 | 58 |
| Shanghai Cuisen Pharmaceutical Technology Co., Ltd. | 13472757003 | yongnan.wang@cendrix.cn | China | 971 | 65 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Jiaxing Novartis Chemical Co., Ltd. | 18957373295 | China | 1579 | 58 | |
| Shanghai AQBioPharma Co., Ltd. | 13661411401 | yinglv.que@aqbiopharma.com.cn | China | 2976 | 58 |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5734 | 55 | |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Xi'an NewProChem Co.,Ltd. | 15332490153 | newprochem@126.com | China | 991 | 55 |
| Ningbo Materials-X Co., Ltd | 0574-87487840-805 15888368997 | China | 473 | 55 |
