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tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate structure

CAS No.: 635698-56-5

Chemical Name:: tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Synonyms: 6-Boc-2,4-Dichloro-5,6,7,...;6-Boc-2,4-Cl2-5,7,8-H3-pyrido[4,3-d]pyrimidine;6-Boc-2,4-dichloro-7,8-dihydro-(5H)-pyrido[4,3-d]pyrimidine;6-Boc-2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine;2,4-Dichloro-,5,6,7,8-tetrahydro-6-Boc-Pyrido[4,3-d]pyrimidine;tert-butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6...;Pyrido[4.3-d]pyriMidine-6(5H)-carboxylicacid. 2.4-dichloro-7.8-d;tert-Butyl 2,4-dichloro-5H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate;ert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate;tert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-6-carboxylate

CBNumber:: CB4757308

Molecular Formula:: C12H15Cl2N3O2

Molecular Weight:: 304.17

MDL Number:: MFCD08273933

MOL File:: 635698-56-5.mol

MSDS File:: SDS

Last updated:2026-09-12 18:52:57

Request For Quotation

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate Properties

Boiling point	423.1±45.0 °C(Predicted)
Density	1.352±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-1.98±0.20(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HazardClass	IRRITANT

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	SC1741	TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 95%	635698-56-5	1G	$23	2026-04-30	Buy
AstaTech	SC1741	TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 95%	635698-56-5	5G	$97	2026-04-30	Buy
AstaTech	SC1741	TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 95%	635698-56-5	25G	$277	2026-04-30	Buy
Synthonix	D4258	tert-butyl 2,4-Dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 97.0%	635698-56-5	250mg	$20	2026-05-06	Buy
Synthonix	D4258	tert-butyl 2,4-Dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 97.0%	635698-56-5	1g	$21	2026-05-06	Buy

Product number	Packaging	Price	Buy
SC1741	1G	$23	Buy
SC1741	5G	$97	Buy
SC1741	25G	$277	Buy
D4258	250mg	$20	Buy
D4258	1g	$21	Buy

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate Chemical Properties, Uses, Production

Uses

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate is a tert-butyl ester compound used in the synthesis of tetrahydropyrimidine derivatives as AHR modulators.

Synthesis

2,4-DICHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE

726697-13-8

24424-99-5

TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE

635698-56-5

2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (270 mg, 1.33 mmol) and di-tert-butyl dicarbonate (348 mg, 1.6 mmol) were used as the starting material, and 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine was dissolved in dichloromethane (30 mL) at 0 °C. Triethylamine (200 mg, 2.0 mmol) was then added and the reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the organic layer was separated by diluting the reaction mixture with dichloromethane (30 mL) and water (30 mL). The aqueous phase was further extracted with dichloromethane (30 mL x 2). All organic layers were combined, washed with brine and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the solvent was removed by concentration under reduced pressure. The resulting crude product was purified by fast column chromatography using a solvent mixture of hexane and ethyl acetate to afford N-BOC-2,4-dichloro-5,7,8-trihydropyrido[4,3-D]pyrimidine (300 mg, 74% yield). Mass spectrometry analysis (LRMS, M+H+): calculated value 305.17; measured value 305.24.

References

[1] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 172; 173
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9480 - 9497

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate synthesis

Synthesis of tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate from 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride and Di-tert-butyl dicarbonate

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate Preparation Products And Raw materials

Raw materials

2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride 1-Benzyl-3-methoxycarbonyl-4-piperidone 6-Benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-dione 6-Benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

1-Benzyl-3-ethoxycarbonyl-4-piperidone Di-tert-butyl dicarbonate Triethylamine Dichloromethane

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Preparation Products

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate Suppliers

Global Suppliers ( 139)

Supplier	Tel	Email	Country	ProdList	Advantage
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
skychemical Co.Ltd	021-20958197 20965099	sales@skychemical.com	China	1182	57
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55

Supplier	Advantage
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Shangchem Co., Ltd.	52
Pure Chemistry Scientific Inc.	62
Shanghai Hanhong Scientific Co.,Ltd.	64
skychemical Co.Ltd	57
Shanghai Topbiochem Technology Co., Ltd	58
Shanghai T&W Pharmaceutical Co., Ltd.	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	55

View Latest Price from tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-13	TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 635698-56-5	$9.80	1g	≥99%	100kg	Career Henan Chemical Co

TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE
635698-56-5
$9.80
≥99%
Career Henan Chemical Co

tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate Spectrum

TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE(635698-56-5)¹HNMR

635698-56-5 (tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate) Related Search:

tert-Butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Pyrimidine, 2-chloro-4-ethyl- (9CI)

2,4-Dichloro-5-methylpyrimidine 2-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Pyrido[4,3-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro- 2,4-Dichloro-6-methylpyrimidine

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2,4-Dichloro-,5,6,7,8-tetrahydro-6-Boc-Pyrido[4,3-d]pyrimidine Pyrido[4.3-d]pyriMidine-6(5H)-carboxylicacid. 2.4-dichloro-7.8-d 6-Boc-2,4-Dichloro-5,6,7,... 6-Boc-2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyriMidine tert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyriMidine-6-carboxylate 6-Boc-2,4-Cl2-5,7,8-H3-pyrido[4,3-d]pyrimidine 2,4-Dichloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid tert-butyl ester tert-Butyl 2,4-dichloro-5H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate ert-butyl 2,4-dichloro-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate tert-butyl 2,4-dichloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate tert-butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6... TIANFUCHEM-- TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 6-Boc-2,4-dichloro-7,8-dihydro-(5H)-pyrido[4,3-d]pyrimidine tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate 635698-56-5 pyrimidine Heterocycle-Pyrimidine series CHIRAL CHEMICALS