4-Bromo-3-methoxyphenol
- CAS No.
- 102127-34-4
- Chemical Name:
- 4-Bromo-3-methoxyphenol
- Synonyms
- -Bromo-3-methoxyphenol;4-Bromo-5-methoxyphenol;3-methoxy-4-bromophenol;4-BROMO-3-METHOXYPHENOL;2-Bromo-5-hydroxyanisole;Phenol, 4-bromo-3-methoxy-;4-Bromo-3-methoxyphenol 98%;4-Bromo-3-methoxyphenol, >=97%
- CBNumber:
- CB0240242
- Molecular Formula:
- C7H7BrO2
- Molecular Weight:
- 203.03
- MDL Number:
- MFCD00029748
- MOL File:
- 102127-34-4.mol
- MSDS File:
- SDS
| Melting point | 75-78°C |
|---|---|
| Boiling point | 279.3±20.0 °C(Predicted) |
| Density | 1.585±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | crystalline powder |
| pka | 9.02±0.18(Predicted) |
| color | Off-white |
| InChI | InChI=1S/C7H7BrO2/c1-10-7-4-5(9)2-3-6(7)8/h2-4,9H,1H3 |
| InChIKey | UYDZUCNMZXCLJI-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(Br)C(OC)=C1 |
| CAS DataBase Reference | 102127-34-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315 | |||||||||
| Precautionary statements | P301+P312+P330-P302+P352 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-37 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29095000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
4-Bromo-3-methoxyphenol price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 729779 | 4-Bromo-3-methoxyphenol 97% | 102127-34-4 | 1g | $146 | 2026-04-30 | Buy |
| AstaTech | 54580 | 4-BROMO-3-METHOXYPHENOL 97% | 102127-34-4 | 5G | $39 | 2026-04-30 | Buy |
| AstaTech | 54580 | 4-BROMO-3-METHOXYPHENOL 97% | 102127-34-4 | 10G | $77 | 2026-04-30 | Buy |
| Apolloscientific | OR30937 | 4-Bromo-3-methoxyphenol 98% | 102127-34-4 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS35244 | 4-Bromo-3-methoxyphenol 98% | 102127-34-4 | 1g | $25 | 2026-06-04 | Buy |
4-Bromo-3-methoxyphenol Chemical Properties, Uses, Production
Chemical Properties
White solid
Synthesis
137396-01-1
102127-34-4
General steps: 1. To a stirred solution of 4-bromoresorcinol (3.0 g, 15.87 mmol) in anhydrous acetone (60 mL) was added K2CO3 (10.97 g, 79.36 mmol, 5.0 eq.) and p-toluenesulfonyl chloride (TsCl, 3.18 g, 16.7 mmol, 1.05 eq.). The reaction mixture was refluxed for 16 hours and then cooled to room temperature. 2. To the reaction mixture was added iodomethane (MeI, 2.47 mL, 39.67 mmol, 2.5 eq.) and refluxed further for 12 hours. After cooling to room temperature, the precipitated solid was filtered. 3. The filtrate was concentrated under pressure and the residue was diluted with water and ethyl acetate (EtOAc, 1:1, 50 mL). Separate the aqueous layer and extract with EtOAc (2 x 30mL). The organic layers were combined, washed with brine, dried (Na2SO4) and concentrated. 4. The residue was purified by silica gel column chromatography using petroleum ether/EtOAc (9:1 to 4:1) as eluent to afford 4-bromo-3-methoxyphenyl-4-methylbenzenesulfonate (5.05 g, 89%) as a white solid. 5. To a stirred solution of the above 4-bromo-3-methoxyphenyl-4-methylbenzenesulfonate (4.2 g, 11.76 mmol) in ethanol (30 mL) was added KOH (1.32 g, 23.52 mmol, 2.0 equiv). The reaction mixture was refluxed for 3 hours and then cooled to room temperature. 6. The solvent was evaporated under reduced pressure and the residue was diluted with water and EtOAc (1:1, 50 mL). The aqueous layer was separated and extracted with EtOAc (2 x 30mL). The organic extracts were combined, washed with brine, dried (Na2SO4) and concentrated. 7. The residue was purified by silica gel column chromatography using petroleum ether/EtOAc (4:1 to 7:3) as eluent to afford 4-bromo-3-methoxyphenol (2.1 g, 88%) as a white solid. 8. To a solution of anhydrous THF (30 mL) of the above 4-bromo-3-methoxyphenol (1.80 g, 8.87 mmol) was added NaH (0.277 g, 11.53 mmol, 1.3 eq.) at 0 °C and stirred for 15 min. 9. tert-Butyldimethylchlorosilane (TBDMSCl, 2.0 g, 13.31 mmol, 1.5 eq.) was added at 0 °C, then slowly warmed to room temperature and the reaction mixture was stirred for 12 hours. 10. Upon completion of the reaction, the reaction was terminated with saturated aqueous NaHCO3 solution (20 mL). The solvent was evaporated under reduced pressure and the aqueous layer was extracted with EtOAc (3 x 20 mL). The organic layers were combined, washed with water and brine, dried (Na2SO4) and concentrated. 11. The residue was purified by silica gel column chromatography using petroleum ether/EtOAc (9.5:0.5 to 9:1) as eluent to give the target product (2.75 g, 98%) as a colorless oil.
References
[1] Journal of the American Chemical Society, 2007, vol. 129, # 13, p. 3918 - 3929
[2] Tetrahedron Asymmetry, 2013, vol. 24, # 20, p. 1281 - 1285
[3] Journal of the American Chemical Society, 1991, vol. 113, # 24, p. 9293 - 9319
[4] Patent: WO2010/148650, 2010, A1. Location in patent: Page/Page column 36
4-Bromo-3-methoxyphenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Yanhua Technology Co., Ltd | 15029556408 | 554033698@qq.com | China | 94 | 58 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4907 | 55 |
| Jiangsu Jingping New Material Technology Co., Ltd. | 18852320356 | 3437818551@qq.com | China | 81 | 58 |
| Shanghai Taifu Pharmaceutical Technology Co., LTD | 13524951390 18930958102 | 1457818861@qq.com | China | 712 | 58 |
| Shenzhen HwaGen Pharmaceutical Co.,Ltd | Q:3003761227 17722620669 | liangcong.yi@rafflespt.com | China | 274 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 4-Bromo-3-methoxyphenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-Bromo-3-methoxyphenol
102127-34-4
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2021-08-12 | 4-Bromo-3-methoxyphenol
102127-34-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 4-Bromo-3-methoxyphenol
102127-34-4
|
$2.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4-Bromo-3-methoxyphenol
102127-34-4
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Bromo-3-methoxyphenol
102127-34-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Bromo-3-methoxyphenol
102127-34-4
- $2.00
- 99%
- Career Henan Chemical Co
