4-Bromo-2-methoxyphenol
- CAS No.
- 7368-78-7
- Chemical Name:
- 4-Bromo-2-methoxyphenol
- Synonyms
- AKOS 225-06;4-BROMOGUAIACOL;B**4-Bromoguaiacol;2-Methoxy-4-Bromophenol;4-BROMO-2-METHOXYPHENOL;5-Bromo-2-hydroxyanisole;Phenol, 4-bromo-2-methoxy-;4-Bromo-2-methoxyphenol 98%;4-Bromo-2-methoxyphenol >4-Bromo-2-Methoxyphenol,>98%
- CBNumber:
- CB8225575
- Molecular Formula:
- C7H7BrO2
- Molecular Weight:
- 203.03
- MDL Number:
- MFCD00051937
- MOL File:
- 7368-78-7.mol
- MSDS File:
- SDS
| Melting point | 34-37 °C (lit.) |
|---|---|
| Boiling point | 129-132°C 12mm |
| Density | 1.585±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform, Methanol |
| pka | 9.40±0.18(Predicted) |
| form | Low Melting Solid or Crystalline Solid |
| color | Colorless to white to pale brown |
| Water Solubility | Slightly soluble in water. |
| BRN | 2045286 |
| InChI | InChI=1S/C7H7BrO2/c1-10-7-4-5(8)2-3-6(7)9/h2-4,9H,1H3 |
| InChIKey | WHSIIJQOEGXWSN-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(Br)C=C1OC |
| CAS DataBase Reference | 7368-78-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Bromoguaiacol(7368-78-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29095000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Bromo-2-methoxyphenol price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 533637 | 4-Bromo-2-methoxyphenol 98% | 7368-78-7 | 25g | $361 | 2023-01-07 | Buy |
| TCI Chemical | B4056 | 4-Bromo-2-methoxyphenol >97.0%(GC)(T) | 7368-78-7 | 5g | $89 | 2026-04-30 | Buy |
| TCI Chemical | B4056 | 4-Bromo-2-methoxyphenol >97.0%(GC)(T) | 7368-78-7 | 25g | $354 | 2026-04-30 | Buy |
| TRC | TRC-B696780-500MG | 4-Bromo-2-methoxyphenol | 7368-78-7 | 500mg | $84 | 2026-06-03 | Buy |
| TRC | TRC-B696780-250MG | 4-Bromo-2-methoxyphenol | 7368-78-7 | 250mg | $72 | 2026-06-03 | Buy |
4-Bromo-2-methoxyphenol Chemical Properties, Uses, Production
Uses
4-bromo-2-methoxyphenol is an important organic intermediate (building block) to synthetize substituted phenzyl products, and it can also be used for the synthesis of polyfunctionalized bicyclic systems.
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Uses
4-Bromo-2-methoxyphenol is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.A. Schoenberg; R. F. Heck. Palladium-catalyzed formylation of aryl, heterocyclic, and vinylic halides. J. Am. Chem. Soc. 1974, 96 (25), 7761-7764.Joel S. Freundlich; Howard E. Landis. An expeditious aqueous Suzuki-Miyaura method for the arylation of bromophenols. Tetrahedron Letters. 2006, 47(25), 4275-4279.
Synthesis
90-05-1
7368-78-7
General procedure for the synthesis of 4-bromo-2-methoxyphenol from guaiacol: NBu4Br3 (1.0 eq.) was dissolved in CH2Cl2 (ca. 5 mL/mmol NBu4Br3), which was immediately added to a CH2Cl2 solution (ca. 5 mL/mmol guaiacol) of guaiacol (1.0 eq.). The reaction mixture was stirred at 23 °C for 2 hours. Subsequently, the solvent was removed under reduced pressure (12 mbar, 40 °C). Water (5.0 mL) was added to the residue and the aqueous layer was extracted with Et2O (3 x 10 mL). The organic layer was separated and dried with MgSO4. The organic solvent was removed under reduced pressure (14 mbar, 40 °C) to give an oily residue, which was finally purified by silica gel column chromatography (SiO2, CH2Cl2).
References
[1] Synthetic Communications, 2007, vol. 37, # 2, p. 323 - 328
[2] Tetrahedron, 2014, vol. 71, # 1, p. 91 - 101
[3] Tetrahedron Letters, 1995, vol. 36, # 10, p. 1705 - 1708
[4] Synlett, 2012, vol. 23, # 7, p. 1082 - 1084
[5] Journal of the Serbian Chemical Society, 2011, vol. 76, # 5, p. 685 - 692
4-Bromo-2-methoxyphenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Puchuang Pharmaceutical Technology Co., Ltd. | 18953403321 | 3218803372@qq.com | China | 283 | 58 |
| Suzhou Xinghuo Biotechnology Co., Ltd. | 19945655289 17736114707 | xinghuoshengwu@163.com | China | 300 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
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- Feb 11,2020
View Latest Price from 4-Bromo-2-methoxyphenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-08 | 4-Bromo-2-methoxyphenol
7368-78-7
|
$1.00 | 1KG | 99.0% | 100kg | Career Henan Chemical Co |
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- 4-Bromo-2-methoxyphenol
7368-78-7
- $1.00
- 99.0%
- Career Henan Chemical Co
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