1-Trityl-1H-1,2,4-triazole
- CAS No.
- 31250-99-4
- Chemical Name:
- 1-Trityl-1H-1,2,4-triazole
- Synonyms
- 1-triphenylmethyl-1,2,4-triazole;1-trityl-1,2,4-triazole;1-Trityl-1H-1,2,4-triazole;1-tribenzyl-1H-1,2,4-triazole;1-(triphenylMethyl)-1H-1,2,4-Triazole;1H-1,2,4-Triazole, 1-(triphenylmethyl)-
- CBNumber:
- CB02446550
- Molecular Formula:
- C21H17N3
- Molecular Weight:
- 311.38
- MDL Number:
- MFCD00962178
- MOL File:
- 31250-99-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1-Trityl-1H-1,2,4-triazole price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00BF41 | 1-Trityl-1H-1,2,4-triazole 98% | 31250-99-4 | 100mg | $5 | 2026-05-28 | Buy |
| aablocks | AA00BF41 | 1-Trityl-1H-1,2,4-triazole 97% | 31250-99-4 | 250mg | $8 | 2026-05-28 | Buy |
| aablocks | AA00BF41 | 1-Trityl-1H-1,2,4-triazole 97% | 31250-99-4 | 1g | $10 | 2026-05-28 | Buy |
| aablocks | AA00BF41 | 1-Trityl-1H-1,2,4-triazole 96% | 31250-99-4 | 25g | $224 | 2026-05-28 | Buy |
| aablocks | AA00BF41 | 1-Trityl-1H-1,2,4-triazole 96% | 31250-99-4 | 100g | $852 | 2026-05-28 | Buy |
1-Trityl-1H-1,2,4-triazole Chemical Properties, Uses, Production
Synthesis
288-88-0
76-83-5
31250-99-4
Triethylamine (5.49 g, 54.30 mmol) was added to a solution of 1,2,4-triazole (3.0 g, 43.44 mmol) in N,N-dimethylformamide (DMF, 50 mL) at room temperature. After stirring for 5 min, triphenylchloromethane (12.11 g, 43.44 mmol) was added and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was partitioned between dichloromethane (50 mL) and water (50 mL) to separate the organic layer. The aqueous layer was extracted with dichloromethane (3 x 50 mL) and the organic layers were combined. The organic layer was washed with water (3 x 40 mL) and then dried over anhydrous sodium sulfate (Na2SO4). The organic layer was concentrated under reduced pressure to afford 1-trityl-1H-1,2,4-triazole (12.6 g, 93% yield). N-butyllithium (n-BuLi, 4.5 mL, 11.24 mmol; 2.5 M hexane solution) was added to a solution of tetrahydrofuran (THF, 120 mL) of 1-trityl-1H-1,2,4-triazole (3.5 g, 11.24 mmol) and stirred for 45 min at -78 °C. Bromine (1.76 g, 11.02 mmol) was added dropwise over 5 min and stirring was continued for 2 h at -78 °C. The reaction mixture was then allowed to slowly warm to -20°C and the reaction was quenched by addition of saturated ammonium chloride (NH4Cl) solution (30 mL). The reaction mixture was diluted with water (60 mL) and dichloromethane (40 mL) and the organic layer was separated. The aqueous layer was extracted with dichloromethane (4 x 50 mL) and the organic layers were combined. The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and the solvent was evaporated under reduced pressure to give the crude product (4.2 g, 95% yield), which was used directly in the next step. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR) data: δ 7.09-7.16 (m, 6H), 7.27-7.40 (m, 9H), 7.86 (s, 1H).
References
[1] Patent: WO2014/159248, 2014, A1. Location in patent: Paragraph 0185
[2] European Journal of Medicinal Chemistry, 2009, vol. 44, # 7, p. 3064 - 3067
[3] Tetrahedron, 1997, vol. 53, # 30, p. 10289 - 10312
[4] MedChemComm, 2014, vol. 5, # 1, p. 72 - 81
[5] Patent: US6620841, 2003, B1
1-Trityl-1H-1,2,4-triazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemShuttle, Inc. | 0510-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. | 02161555100 | China | 820 | 58 | |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9383 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 10000 | 58 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 7991 | 58 |
View Latest Price from 1-Trityl-1H-1,2,4-triazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-TRITYL-1H-1,2,4-TRIAZOLE
31250-99-4
|
$1.00 | 1KG | 95% | 500KG | Career Henan Chemical Co |
-
- 1-TRITYL-1H-1,2,4-TRIAZOLE
31250-99-4
- $1.00
- 95%
- Career Henan Chemical Co
