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2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE structure

CAS No.: 72587-18-9

Chemical Name:: 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE

Synonyms: 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDIMINE;3-Amino-2-chloro-5-(trifluoromethyl)pyrid;2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE;2-Chloro-5-(trifluoroMethyl)pyridin-3-aMine;3-Amino-2-chloro-5-(trifluoromethyl)pyridine;5-(TRIFLUOROMETHYL)-3-AMINO-2-CHLOROPYRIDINE;2-Chloro-3-amine-5-(trifluoromethyl)pyridine;3-Pyridinamine, 2-chloro-5-(trifluoromethyl)-;2-Chloro-5-(trifluoromethyl)-pyridin-3-ylamine

CBNumber:: CB02448589

Molecular Formula:: C6H4ClF3N2

Molecular Weight:: 196.56

MDL Number:: MFCD07375383

MOL File:: 72587-18-9.mol

Last updated:2025-08-18 19:12:29

Product description	Number	Pack Size	Price
2-Chloro-5-(trifluoromethyl)pyridin-3-amine	C351480	250mg	$45
2-Chloro-5-(trifluoromethyl)pyridin-3-amine	J51116	1g	$30
3-Amino-2-chloro-5-(trifluoromethyl)pyridine 98%	054655	1g	$35
2-Chloro-5-(trifluoromethyl)pyridin-3-amine 97%	3H30-7-1F	10g	$256
3-Amino-2-chloro-5-(trifluoromethyl)pyridine 98%	054655	5g	$139
More product size

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2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE Properties

Boiling point	256.8±40.0 °C(Predicted)
Density	1.507±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	Solid
pka	-0.29±0.10(Predicted)
color	Off-white to brown
Water Solubility	Slightly soluble in water.
CAS DataBase Reference	72587-18-9

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H315-H319-H332-H335

Precautionary statements

P261-P280-P304+P340-P305+P351+P338-P405-P501a

HazardClass

IRRITANT

HS Code

2933399990

NFPA 704

	0
2		0

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C351480	2-Chloro-5-(trifluoromethyl)pyridin-3-amine	72587-18-9	250mg	$45	2021-12-16	Buy
AK Scientific	J51116	2-Chloro-5-(trifluoromethyl)pyridin-3-amine	72587-18-9	1g	$30	2021-12-16	Buy
Matrix Scientific	054655	3-Amino-2-chloro-5-(trifluoromethyl)pyridine 98%	72587-18-9	1g	$35	2021-12-16	Buy
SynQuest Laboratories	3H30-7-1F	2-Chloro-5-(trifluoromethyl)pyridin-3-amine 97%	72587-18-9	10g	$256	2021-12-16	Buy
Matrix Scientific	054655	3-Amino-2-chloro-5-(trifluoromethyl)pyridine 98%	72587-18-9	5g	$139	2021-12-16	Buy

Product number	Packaging	Price	Buy
C351480	250mg	$45	Buy
J51116	1g	$30	Buy
054655	1g	$35	Buy
3H30-7-1F	10g	$256	Buy
054655	5g	$139	Buy

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE Chemical Properties,Uses,Production

Uses

It's employed as a intermediate for pharmaceutical.

Synthesis

2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE

72587-15-6

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE

72587-18-9

The general procedure for the synthesis of 3-amino-2-chloro-5-(trifluoromethyl)pyridine from 5-(trifluoromethyl)-3-nitro-2-chloropyridine was as follows: zinc(II) dichloride dihydrate (4.39 g, 19.5 mmol) was added to 2-chloro-3-nitro-5-(trifluoromethyl)pyridine (1.00 g, 4.41 mmol) in ethyl acetate (25 mL) solution. The resulting suspension was stirred at 80°C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and then slowly added dropwise to an ice-cooled saturated sodium bicarbonate solution (100 mL). After the temperature was brought to room temperature, the product was separated. The suspension was filtered through a diatomaceous earth layer and the residue was washed four times with ethyl acetate (50 mL each time). The filtrate and washings were combined and washed sequentially with saturated sodium bicarbonate solution, water and saturated aqueous sodium chloride solution. The organic phase was dried over magnesium sulfate, filtered and concentrated to dryness. Yield: 0.78 g (90%). 1H-NMR (CD2Cl2, 400 MHz) data were as follows: δ=4.4 (br s, 2H), 7.24 (d, 1H), 8.02 (d, 1H).

References

[1] Patent: US2012/319050, 2012, A1. Location in patent: Page/Page column 64-65
[2] Patent: WO2012/172482, 2012, A1. Location in patent: Page/Page column 126
[3] Patent: WO2017/133657, 2017, A1. Location in patent: Page/Page column 64
[4] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 175; 176

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE Preparation Products And Raw materials

Raw materials

2-CHLORO-3-NITRO-5-(TRIFLUOROMETHYL)PYRIDINE Stannous chloride Ethyl acetate

Preparation Products

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE Suppliers

Global( 82)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8645	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Antai Fine Chemical Technology Co.,Limited	58
CR Corporation Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-13	2-Chloro-5-(trifluoromethyl)-3-pyridinamine 72587-18-9	US $1.10-9.90 / kg	1kg	99%min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2020-01-14	2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE 72587-18-9	US $1.00 / g	1g	99%	200kg	Career Henan Chemical Co
2020-01-09	2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE 72587-18-9	US $1.00 / KG	1KG	95-99%	1ton	Career Henan Chemical Co

2-Chloro-5-(trifluoromethyl)-3-pyridinamine
72587-18-9
US $1.10-9.90 / kg
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE
72587-18-9
US $1.00 / g
99%
Career Henan Chemical Co

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE
72587-18-9
US $1.00 / KG
95-99%
Career Henan Chemical Co

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE Spectrum

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE(72587-18-9)¹HNMR

72587-18-9(2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE)Related Search:

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1of4

2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE 5-(TRIFLUOROMETHYL)-3-AMINO-2-CHLOROPYRIDINE 3-Amino-2-chloro-5-(trifluoromethyl)pyridine 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDIMINE 2-Chloro-5-(trifluoroMethyl)pyridin-3-aMine 3-Amino-2-chloro-5-(trifluoromethyl)pyrid 2-Chloro-3-amine-5-(trifluoromethyl)pyridine 3-Pyridinamine, 2-chloro-5-(trifluoromethyl)- 2-Chloro-5-(trifluoromethyl)-pyridin-3-ylamine 72587-18-9