2-Chloro-5-(trifluoromethyl)-3-pyridinamine
- CAS No.
- 72587-18-9
- Chemical Name:
- 2-Chloro-5-(trifluoromethyl)-3-pyridinamine
- Synonyms
- 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDIMINE;3-Amino-2-chloro-5-(trifluoromethyl)pyrid;2-Chloro-5-(trifluoromethyl)-3-pyridinamine;2-Chloro-5-(trifluoroMethyl)pyridin-3-aMine;3-Amino-2-chloro-5-(trifluoromethyl)pyridine;5-(TRIFLUOROMETHYL)-3-AMINO-2-CHLOROPYRIDINE;2-Chloro-3-amine-5-(trifluoromethyl)pyridine;3-Pyridinamine, 2-chloro-5-(trifluoromethyl)-;2-Chloro-5-(trifluoromethyl)-pyridin-3-ylamine
- CBNumber:
- CB02448589
- Molecular Formula:
- C6H4ClF3N2
- Molecular Weight:
- 196.56
- MDL Number:
- MFCD07375383
- MOL File:
- 72587-18-9.mol
- MSDS File:
- SDS
| Boiling point | 256.8±40.0 °C(Predicted) |
|---|---|
| Density | 1.507±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -0.29±0.10(Predicted) |
| form | Solid |
| color | Off-white to brown |
| Water Solubility | Slightly soluble in water. |
| CAS DataBase Reference | 72587-18-9 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
2-Chloro-5-(trifluoromethyl)-3-pyridinamine price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC201291 | 2-Chloro-5-(trifluoromethyl)pyridin-3-amine 98% | 72587-18-9 | 1g | $39 | 2026-06-04 | Buy |
| Apolloscientific | PC201291 | 2-Chloro-5-(trifluoromethyl)pyridin-3-amine 98% | 72587-18-9 | 5g | $126 | 2026-06-04 | Buy |
| Apolloscientific | PC201291 | 2-Chloro-5-(trifluoromethyl)pyridin-3-amine 98% | 72587-18-9 | 10g | $209 | 2026-06-04 | Buy |
| AK Scientific | W8116 | 2-Chloro-5-(trifluoromethyl)pyridin-3-amine 98%(GC) | 72587-18-9 | 1g | $16 | 2026-06-04 | Buy |
| AK Scientific | W8116 | 2-Chloro-5-(trifluoromethyl)pyridin-3-amine 98%(GC) | 72587-18-9 | 5g | $34 | 2026-06-04 | Buy |
2-Chloro-5-(trifluoromethyl)-3-pyridinamine Chemical Properties,Uses,Production
Uses
It's employed as a intermediate for pharmaceutical.
Synthesis
72587-15-6
72587-18-9
The general procedure for the synthesis of 3-amino-2-chloro-5-(trifluoromethyl)pyridine from 5-(trifluoromethyl)-3-nitro-2-chloropyridine was as follows: zinc(II) dichloride dihydrate (4.39 g, 19.5 mmol) was added to 2-chloro-3-nitro-5-(trifluoromethyl)pyridine (1.00 g, 4.41 mmol) in ethyl acetate (25 mL) solution. The resulting suspension was stirred at 80°C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and then slowly added dropwise to an ice-cooled saturated sodium bicarbonate solution (100 mL). After the temperature was brought to room temperature, the product was separated. The suspension was filtered through a diatomaceous earth layer and the residue was washed four times with ethyl acetate (50 mL each time). The filtrate and washings were combined and washed sequentially with saturated sodium bicarbonate solution, water and saturated aqueous sodium chloride solution. The organic phase was dried over magnesium sulfate, filtered and concentrated to dryness. Yield: 0.78 g (90%). 1H-NMR (CD2Cl2, 400 MHz) data were as follows: δ=4.4 (br s, 2H), 7.24 (d, 1H), 8.02 (d, 1H).
References
[1] Patent: US2012/319050, 2012, A1. Location in patent: Page/Page column 64-65
[2] Patent: WO2012/172482, 2012, A1. Location in patent: Page/Page column 126
[3] Patent: WO2017/133657, 2017, A1. Location in patent: Page/Page column 64
[4] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 175; 176
2-Chloro-5-(trifluoromethyl)-3-pyridinamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Runpharm Technology Limited | 18171398856 2968382473 | service@runpharm.com | China | 716 | 55 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 |
View Lastest Price from 2-Chloro-5-(trifluoromethyl)-3-pyridinamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2-Chloro-5-(trifluoromethyl)-3-pyridinamine
72587-18-9
|
$1.10-9.90 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2020-01-14 | 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE
72587-18-9
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co | |
 |
2020-01-09 | 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE
72587-18-9
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- 2-Chloro-5-(trifluoromethyl)-3-pyridinamine
72587-18-9
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE
72587-18-9
- $1.00
- 99%
- Career Henan Chemical Co
-
- 2-CHLORO-5-(TRIFLUOROMETHYL)-3-PYRIDINAMINE
72587-18-9
- $1.00
- 95-99%
- Career Henan Chemical Co
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