ChemicalBook >> CAS DataBase List >>TCS 46B
TCS 46B
- CAS No.
- 302799-86-6
- Chemical Name:
- TCS 46B
- Synonyms
- TCS 46B;1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one;5-(3-(4-benzylpiperidin-1-yl)prop-1-yn-1-yl)-1H-benzo[d]imidazol-2(3H)-one;5-(3-(4-Benzylpiperidin-1-yl)prop-1-yn-1-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one;2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-
- CBNumber:
- CB02453446
- Molecular Formula:
- C22H23N3O
- Molecular Weight:
- 345.44
- MDL Number:
- MFCD09971137
- MOL File:
- 302799-86-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-27 17:00:41
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
TCS 46B price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42123 | TCS 46b ≥98% | 302799-86-6 | 5mg | $80 | 2026-04-30 | Buy |
| Cayman Chemical | 42123 | TCS 46b ≥98% | 302799-86-6 | 10mg | $151 | 2026-04-30 | Buy |
| Cayman Chemical | 42123 | TCS 46b ≥98% | 302799-86-6 | 25mg | $357 | 2026-04-30 | Buy |
| Cayman Chemical | 42123 | TCS 46b ≥98% | 302799-86-6 | 50mg | $634 | 2026-04-30 | Buy |
| Usbiological | 466895 | TCS 46b | 302799-86-6 | 10mg | $418 | 2026-06-03 | Buy |
TCS 46B Chemical Properties, Uses, Production
Uses
TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist.
Biological Activity
Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC 50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.
in vivo
TCS 46b (Compound 46b; 10 and 30 mg/kg; p.o. or i.p.; once) potentiates the effects of L-DOPA in the 6-OHDA-lesioned rat[1].
| Animal Model: | SpragueDawley rats, 6-hydroxydopamine-lesioned (6-OHDA) rat model[1] |
| Dosage: | 10 and 30 mg/kg |
| Administration: | PO or IP, once |
| Result: | Showed significant potentiation of the effects of L-DOPA in this model. |
TCS 46B Preparation Products And Raw materials
Raw materials
Preparation Products
TCS 46B Suppliers
Global Suppliers ( 47)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | nanfengpharma@126.co 18616377689 | nanfengpharma@126.com | China | 20008 | 58 |
| Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | 1580084073@qq.com | China | 991 | 58 |
TCS 46B
1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one
2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-
5-(3-(4-benzylpiperidin-1-yl)prop-1-yn-1-yl)-1H-benzo[d]imidazol-2(3H)-one
5-(3-(4-Benzylpiperidin-1-yl)prop-1-yn-1-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
302799-86-6
