CAY10397
- CAS No.
- 78028-01-0
- Chemical Name:
- CAY10397
- Synonyms
- CK47A;CAY10397;Ph CK 47A;CAY-10397,CAY10397;DPHOCQNZARWEHS-UHFFFAOYSA-N;5-[[4-(ETHOXYCARBONYL)PHENYL]AZO]-2-HYDROXY-BENZENEACETIC ACID;5-[2-[4-(Ethoxycarbonyl)phenyl]diazenyl]-2-hydroxybenzeneacetic acid;5-[[4-(Ethoxycarbonyl)phenyl]azo]-2-hydroxybenzeneacetic acid, CK47A;Benzeneacetic acid, 5-[2-[4-(ethoxycarbonyl)phenyl]diazenyl]-2-hydroxy-
- CBNumber:
- CB0245681
- Molecular Formula:
- C17H16N2O5
- Molecular Weight:
- 328.32
- MDL Number:
- MFCD03412024
- MOL File:
- 78028-01-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 578.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | 0.1 M Na2CO3: 200 μg/ml; DMF: 35 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml |
| form | solid |
| pka | 4.05±0.10(Predicted) |
| InChI | 1S/C17H16N2O5/c1-2-24-17(23)11-3-5-13(6-4-11)18-19-14-7-8-15(20)12(9-14)10-16(21)22/h3-9,20H,2,10H2,1H3,(H,21,22)/b19-18+ |
| InChIKey | YYBSDOZYJSGLTH-VHEBQXMUSA-N |
| SMILES | CCOC(=O)c1ccc(cc1)\N=N\c2ccc(O)c(CC(O)=O)c2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
CAY10397 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6734 | CAY10397 >98%, solid | 78028-01-0 | 1mg | $188 | 2026-04-30 | Buy |
| Cayman Chemical | 70130 | CAY10397 ≥98% | 78028-01-0 | 1mg | $65 | 2026-04-30 | Buy |
| Cayman Chemical | 70130 | CAY10397 ≥98% | 78028-01-0 | 5mg | $279 | 2026-04-30 | Buy |
| Cayman Chemical | 70130 | CAY10397 ≥98% | 78028-01-0 | 10mg | $493 | 2026-04-30 | Buy |
| Cayman Chemical | 70130 | CAY10397 ≥98% | 78028-01-0 | 25mg | $1077 | 2026-04-30 | Buy |
CAY10397 Chemical Properties, Uses, Production
Uses
Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This enzyme oxidizes the 15-hydroxyl group and hydrogenates the 13,14-double bond, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity. CAY10397 is a selective inhibitor of 15-hydroxy PGDH with an IC50 of approximately 10 μM. CAY10397 acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.[Cayman Chemical]
Definition
ChEBI: CAY10397 is a member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 4 by an ethoxycarbonyl group, while the other is substituted by a carboxymethyl group at position 3 and a hydroxy group at position 4. It is a potent and selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH). It has a role as an EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor. It is a dicarboxylic acid monoester, an ethyl ester, a member of azobenzenes and a member of phenols.
Biological Activity
Potent and selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH). Acts to prolong the lifetime and activity of endogenously produced prostaglandins both in vitro and in vivo.
CAY10397 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shaanxi Didu Pharmaceutical Co., Ltd. | 029-81124775 17791530730 | 1079@dideu.com | China | 10000 | 58 |
