Pyridine, 5-bromo-2-(difluoromethyl)-
- CAS No.
- 845827-13-6
- Chemical Name:
- Pyridine, 5-bromo-2-(difluoromethyl)-
- Synonyms
- 3-Bromo-6-(difluoromethyl)pyridine;Pyridine, 5-bromo-2-(difluoromethyl)-;5-Bromo-2-(difluoromethyl)pyridine 95%;5-Bromo-alpha,alpha-difluoro-2-picoline
- CBNumber:
- CB02468671
- Molecular Formula:
- C6H4BrF2N
- Molecular Weight:
- 208
- MDL Number:
- MFCD11977429
- MOL File:
- 845827-13-6.mol
- MSDS File:
- SDS
| Melting point | 35-40℃ |
|---|---|
| Boiling point | 206.6±35.0 °C(Predicted) |
| Density | 1.64 |
| Flash point | 89°(192°F) |
| storage temp. | 2-8°C |
| form | Solid |
| pka | -0.83±0.29(Predicted) |
| color | White to yellow |
| InChI | InChI=1S/C6H4BrF2N/c7-4-1-2-5(6(8)9)10-3-4/h1-3,6H |
| InChIKey | QXLZRIGSWWQOLG-UHFFFAOYSA-N |
| SMILES | C1(C(F)F)=NC=C(Br)C=C1 |
| CAS DataBase Reference | 845827-13-6 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-45 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Pyridine, 5-bromo-2-(difluoromethyl)- price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 741299 | 5-Bromo-2-(difluoromethyl)pyridine 95% | 845827-13-6 | 500mg | $103 | 2023-06-20 | Buy |
| Apolloscientific | PC49144 | 5-Bromo-2-(difluoromethyl)pyridine 98% | 845827-13-6 | 1g | $55 | 2026-06-04 | Buy |
| Apolloscientific | PC49144 | 5-Bromo-2-(difluoromethyl)pyridine 98% | 845827-13-6 | 5g | $270 | 2026-06-04 | Buy |
| Activate Scientific | AS41974 | 5-Bromo-2-(difluoromethyl)pyridine 97% | 845827-13-6 | 1g | $65 | 2026-06-04 | Buy |
| Activate Scientific | AS41974 | 5-Bromo-2-(difluoromethyl)pyridine 97% | 845827-13-6 | 5g | $246 | 2026-06-04 | Buy |
Pyridine, 5-bromo-2-(difluoromethyl)- Chemical Properties, Uses, Production
Synthesis
31181-90-5
845827-13-6
General procedure for the synthesis of 5-bromo-2-difluoromethylpyridine from 5-bromo-2-pyridinecarboxaldehyde: To a cooled solution of 5-bromopyridine-2-carboxaldehyde (A) (7.0 g, 38 mmol) in dichloromethane (300 mL) was slowly added diethylaminosulfur trifluoride (DAST, 10.8 mL, 83 mmol) at -78 °C. The reaction mixture was gradually warmed to room temperature over a period of 6 h. The reaction was subsequently quenched by the slow addition of water. The reaction mixture was washed with saturated aqueous sodium bicarbonate solution and dried with anhydrous sodium sulfate. Concentration and purification by silica gel column chromatography (dichloromethane as eluent) afforded 5-bromo-2-difluoromethylpyridine (B) as brown crystals (5.3 g, 67% yield).1H NMR (300 MHz, CDCl3) δ 8.8 (s, 1H), 8.0 (d, 1H), 7.6 (d, 1H), 6.6 (t, 1H).
References
[1] Patent: US2012/302608, 2012, A1. Location in patent: Page/Page column 11
[2] Patent: WO2006/109729, 2006, A1. Location in patent: Page/Page column 168-169
[3] Patent: US2009/23782, 2009, A1. Location in patent: Page/Page column 13
[4] Patent: US2010/168178, 2010, A1. Location in patent: Page/Page column 11
[5] Patent: US2010/168177, 2010, A1. Location in patent: Page/Page column 11
Pyridine, 5-bromo-2-(difluoromethyl)- Preparation Products And Raw materials
Pyridine, 5-bromo-2-(difluoromethyl)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Helai Biotech Co. Ltd. | 15721400568 | helaibiotech@163.com | China | 155 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Santai Labs, Inc. | 519-85601385 | marketing@santailabs.com | China | 891 | 62 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3821 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Shanghai potentpharm CO.,Ltd | 13524892556 | sales-cn@potentpharm.com | China | 1011 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from Pyridine, 5-bromo-2-(difluoromethyl)- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 5-Bromo-2-(difluoromethyl)pyridine
845827-13-6
|
$1.00 | 1g | 95-99% | 1ton | Career Henan Chemical Co | |
 |
2020-01-10 | 5-Bromo-2-(difluoromethyl)pyridine
845827-13-6
|
$1.00 | 1g | 95-99% | 1ton | Career Henan Chemical Co |
-
- 5-Bromo-2-(difluoromethyl)pyridine
845827-13-6
- $1.00
- 95-99%
- Career Henan Chemical Co
-
- 5-Bromo-2-(difluoromethyl)pyridine
845827-13-6
- $1.00
- 95-99%
- Career Henan Chemical Co
