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5-Bromopyridine-2-carbaldehyde

5-Bromopyridine-2-carbaldehyde structure

CAS No.: 31181-90-5

Chemical Name:: 5-Bromopyridine-2-carbaldehyde

Synonyms: 5-BROMOPICOLINALDEHYDE;5-BROMO-2-PYRIDINECARBOXALDEHYDE;5-BROMO-PYRIDINE-2-CARBALDEHYDE;5-BROMO-2-FORMYLPYRIDINE;2-Formyl-5-Bromopyridine;5-Bromo-2-formylpyridine, 5-Bromo-2-picolinaldehyde;5-Bromopyridine-2-carbaL;5-Bromo-2-picolinaldehyde;5-Bromo-2-Pyridinaldehyde;5-BroM-3-pyridincarbaldehyd

CBNumber:: CB8352244

Molecular Formula:: C6H4BrNO

Molecular Weight:: 186.01

MDL Number:: MFCD04112535

MOL File:: 31181-90-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:07:17

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5-Bromopyridine-2-carbaldehyde Properties

Melting point	91-96 °C
Boiling point	70°C/26mmHg(lit.)
Density	1.683±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	1.36±0.10(Predicted)
form	powder to crystal
color	White to Light yellow to Light orange
Water Solubility	Insoluble in water.
Sensitive	Air Sensitive
InChI	InChI=1S/C6H4BrNO/c7-5-1-2-6(4-9)8-3-5/h1-4H
InChIKey	ZQVLPMNLLKGGIU-UHFFFAOYSA-N
SMILES	C1(C=O)=NC=C(Br)C=C1
CAS DataBase Reference	31181-90-5(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38-20/21/22

Safety Statements

22-26-36/37/39-36

WGK Germany

HazardClass

IRRITANT

HS Code

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	1
2		0

5-Bromopyridine-2-carbaldehyde price More Price(96)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	694177	5-Bromo-2-pyridinecarboxaldehyde 95%	31181-90-5	1g	$89.7	2026-04-30	Buy
TCI Chemical	B3489	5-Bromo-2-pyridinecarboxaldehyde >98.0%(GC)	31181-90-5	1g	$27	2026-04-30	Buy
Usbiological	276029	2-Formyl-5-bromopyridine Asreported	31181-90-5	1g	$297	2026-06-03	Buy
Usbiological	276029	2-Formyl-5-bromopyridine Asreported	31181-90-5	2g	$409	2026-06-03	Buy
Usbiological	276029	2-Formyl-5-bromopyridine Asreported	31181-90-5	5g	$573	2026-06-03	Buy

Product number	Packaging	Price	Buy
694177	1g	$89.7	Buy
B3489	1g	$27	Buy
276029	1g	$297	Buy
276029	2g	$409	Buy
276029	5g	$573	Buy

5-Bromopyridine-2-carbaldehyde Chemical Properties, Uses, Production

Chemical Properties

Light yellow Cryst

Uses

5-Bromopyridine-2-carboxaldehyde is used as organic chemical synthesis intermediate.

Synthesis

624-28-2

68-12-2

31181-90-5

5-Bromo-2-pyridinecarboxaldehyde was synthesized according to General Method C using 2,5-dibromopyridine and N,N-dimethylformamide (DMF) as raw materials. The specific operation was as follows: 2,5-dibromopyridine (237 mg, 1 mmol) was mixed with DMF (115 μL, 1.5 mmol) for the reaction. After completion of the reaction, the crude product was purified by fast column chromatography (eluent: hexane/ethyl acetate = 10:1) to afford the target compound 5-bromo-2-pyridinecarboxaldehyde (27b) as a brown solid (149 mg, 80% yield). Thin layer chromatography (TLC) analysis showed an Rf value of 0.45 (Expander: hexane/ethyl acetate = 8:1). Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, CDCl3) data were as follows: δ 10.03 (1H, s), 8.85 (1H, dd, J = 0.8, 2.0 Hz), 8.02 (1H, ddd, J = 0.8, 2.0, 8.0 Hz), 7.85 (1H, dd, J = 0.8, 8.0 Hz). The nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, CDCl3) data were as follows: δ 192.4, 151.7, 151.3, 140.0, 126.3, 122.8. The spectral data obtained were in agreement with literature reports.

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 22, p. 5852 - 5869
[2] Patent: WO2007/15744, 2007, A1. Location in patent: Page/Page column 58-59
[3] Chemistry - A European Journal, 2006, vol. 12, # 13, p. 3472 - 3483
[4] Patent: WO2006/22794, 2006, A1. Location in patent: Page/Page column 49
[5] Tetrahedron Letters, 2000, vol. 41, # 22, p. 4335 - 4338

5-Bromopyridine-2-carbaldehyde synthesis

Synthesis of 5-Bromopyridine-2-carbaldehyde from 5-Bromo-2-pyridinecarbonitrile

5-Bromopyridine-2-carbaldehyde Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 3-Chloroperoxybenzoic acid Triethylamine Chloroform Trifluoroacetic anhydride

Ethyl acetate 5-Bromo-2-methylpyridine Methanol Oxalyl chloride Sodium thiosulfate pentahydrate

2-Pyridinemethanol, 5-bromo-, 2-acetate 5-Bromo-2-(dibromomethyl)pyridine 5-Bromo-2-hydroxymethylpyridine 5-Bromo-2-pyridinecarbonitrile 2-FORMYL-5-PICOLINE

5-Bromo-2-methylpyridine N-oxide 5-Bromo-2-iodopyridine

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Preparation Products

5-Bromopyridine-2-carboxylic acid methyl ester

5-Bromopyridine-2-carbaldehyde Suppliers

Global Suppliers ( 439)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Xuande Pharmaceutical Technology Co. LTD	18866895588	dingjiaying@shiningpharm.com	China	184	55
DKD Shijiazhuang Chemical Co., Ltd.	0311-67790228 15531158659	2361184479@qq.com	China	300	62
Beijing Bankchem Pharmatech Co.,Ltd.	010-80236392 17600588818	bankchem@163.com	China	247	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
Shanghai Toplab Chemical Co., Ltd.	021-31137757-00; 18121466954;18121466954	28328681@qq.com	China	184	55
Anhui Yongsheng Pharmaceutical Technology Co., Ltd	3307 18017383231	983544897@qq.com	China	942	58
Shanghai Fuchunle Biotechnology Co., Ltd.	15902102743 18121362927	shelley@fortunabiotech.com	China	108	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66

Supplier	Advantage
Shandong Xuande Pharmaceutical Technology Co. LTD	55
DKD Shijiazhuang Chemical Co., Ltd.	62
Beijing Bankchem Pharmatech Co.,Ltd.	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
Shanghai Toplab Chemical Co., Ltd.	55
Anhui Yongsheng Pharmaceutical Technology Co., Ltd	58
Shanghai Fuchunle Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66

View Latest Price from 5-Bromopyridine-2-carbaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	5-Bromo-2-pyridinecarbaldehyde 31181-90-5	$1.10-9.90	1KG	99% min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-08-20	5-Bromopyridine-2-carbaldehyde 31181-90-5	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-06-30	5-Bromopyridine-2-carbaldehyde 31181-90-5		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd

5-Bromo-2-pyridinecarbaldehyde
31181-90-5
$1.10-9.90
99% min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

5-Bromopyridine-2-carbaldehyde
31181-90-5
$1.10
99.00%
Dideu Industries Group Limited

5-Bromopyridine-2-carbaldehyde
31181-90-5
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

5-Bromopyridine-2-carbaldehyde Spectrum

5-Bromopyridine-2-carbaldehyde(31181-90-5)¹HNMR 5-Bromopyridine-2-carbaldehyde(31181-90-5)FT-IR

31181-90-5 (5-Bromopyridine-2-carbaldehyde) Related Search:

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2,6-Lutidine 2-Pyridinecarboxaldehyde 5-bromo-2-pyridinecarboxylic acid ethyl ester N-Methyl 5-bromopicolinamide N-Ethyl 5-bromopicolinamide

Methyl 6-bromonicotinate 1-(5-Bromo-pyridin-2-yl)-ethanone 5-Bromopyridine-2-carboxylic acid methyl ester 3,5-Dibromopicolinic acid 5-Bromopyridine-2-carboxamide 97%5-bromopicolinamide

5-Bromo-4-methyl-pyridine-2-carboxylic acid 5-Bromo-pyridine-2-carboxylic acid dimethylamide 5-Bromopyridine-2-carbonyl chloride

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5-BROMO-2-PYRIDINECARBALDEHYDE 5-BROMOPYRIDINE-2-CARBALDEHYDE(MFCD04112535) 5-Bromo-2-formylpyridine, 5-Bromo-2-picolinaldehyde 2-Formyl-5-Bromopyridine 5-Bromopyridine-2-carboxaldehyde 95% 2-FORMYL-5-BROMOPYRIDINE / 5-BROMO-2-FORMYLPYRIDINE 5-BROMO-2-PYRIDINECARBOXALDEHYDE / 5-BROMONICOTINALDEHYDE 5-Bromo-2-picolinaldehyde 2-Pyridinecarboxaldehyde, 5-bromo- 5-Bromo-2-pyridinecarboxaldehyde,5-Bromo-2-picolinaldehyde 5-BroMopyridine-2-carboxa... 5-Bromo-2-formylpyridine, 5-Bromopicolinaldehyde 5-BroM-3-pyridincarbaldehyd 5--2-broMinepyridineforMaldehyde 5-Bromopyridine-2-carboxaldehyde,99% 5-Bromo-2-pyridinecarboxaldehyde 95% 5-BROMOPYRIDINE-2-CARBOXALDEHYDE 5-Bromo-2-pyridinecarboxaldehyde > 5-Bromopyridine-2-carbaL 5-Bromopyridine-2-carboxaldeyhde 5-Bromopyridine-2-carbaldehyde ISO 9001：2015 REACH 5- bromo -2- pyridine formaldehyde 31181-90-5 5-Bromo-2-Pyridinaldehyde 5-BROMOPICOLINALDEHYDE 5-BROMO-PYRIDINE-2-CARBALDEHYDE 5-BROMO-2-PYRIDINECARBOXALDEHYDE 5-BROMO-2-FORMYLPYRIDINE 31181-90-5 31181-07-2 Aldehyde pharmacetical Aldehyde Building Blocks Carbonyl Compounds Heterocycles Aldehydes blocks Bromides Pyridines Pyridine Pyridine Series 31181-90-5