4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
- CAS No.
- 151103-09-2
- Chemical Name:
- 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
- Synonyms
- Roflumilast intermediate A;3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde;Roflumilast Impurity 32;RofluMilast interMediate;RofluMilast InterMediate I;Intermediate Of Roflumilast;Benzaldehyde, 3-(cyclopropylMethoxy)-4;ROFLUMILAST INTERMEDIATE CAS 151103-09-2;4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOX...;3-CyclopropylMethoxy-4-isopropoxy-benzaldehyde
- CBNumber:
- CB9259483
- Molecular Formula:
- C12H12F2O3
- Molecular Weight:
- 242.22
- MDL Number:
- MFCD07779381
- MOL File:
- 151103-09-2.mol
- MSDS File:
- SDS
| Boiling point | 331.3±37.0 °C(Predicted) |
|---|---|
| Density | 1.277±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C12H12F2O3/c13-12(14)17-10-4-3-9(6-15)5-11(10)16-7-8-1-2-8/h3-6,8,12H,1-2,7H2 |
| InChIKey | AHVVCELVGCPYGI-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C997803 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde | 151103-09-2 | 50mg | $45 | 2021-12-16 | Buy |
| TRC | C997803 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde | 151103-09-2 | 100mg | $60 | 2021-12-16 | Buy |
| AK Scientific | X3187 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde | 151103-09-2 | 1g | $146 | 2021-12-16 | Buy |
| Matrix Scientific | 081566 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde 97% | 151103-09-2 | 1g | $375 | 2021-12-16 | Buy |
| AK Scientific | X3187 | 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde | 151103-09-2 | 10g | $492 | 2021-12-16 | Buy |
4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Chemical Properties,Uses,Production
Synthesis
7051-34-5
151103-08-1
151103-09-2
The general procedure for the synthesis of 4-(difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde from bromomethylcyclopropane and 4-difluoromethoxy-3-hydroxybenzaldehyde was as follows: 55 g of 4-(difluoromethoxy)-3-hydroxybenzaldehyde, 42.42 g of K2CO3 (1.05 eq.), 4.86 g of KI (0.1 eq.), and 220 mL of dimethyl sulfoxide ( DMSO) were added to the reactor. The mixture was heated and stirred at 70 °C for 1 hour. Subsequently, a pre-prepared mixture of 42.65 g of bromomethylcyclopropane (1.08 eq.) and 110 mL of DMSO was slowly added dropwise for a controlled time of 1 hour. After the dropwise addition was completed, the reaction was continued at 70 °C for 3 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature. The reaction mixture was diluted by adding 375 mL of toluene and filtered to remove unreacted K2CO3. The filtrate was cooled to 0-5 °C and 375 mL of deionized water was added. The organic and aqueous phases were separated and the organic phase was washed twice with 55 mL of deionized water. Finally, the solvent was removed by distillation under reduced pressure to give 70 g (99% yield) of 4-(difluoromethoxy)-3-(cyclopropylmethoxy)benzaldehyde as a viscous pale yellow liquid.
References
[1] Patent: WO2014/60464, 2014, A1. Location in patent: Page/Page column 15
[2] Patent: CN105254559, 2016, A. Location in patent: Paragraph 0041; 0042
[3] Patent: US2008/15226, 2008, A1. Location in patent: Page/Page column 10
[4] Patent: US2006/116373, 2006, A1. Location in patent: Page/Page column 6
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 38, p. 6900 - 6908
4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2953 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-12 | 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
151103-09-2
|
US $0.00-0.00 / kg | 5kg | 99.9%HPLC; USP42 | 500 KGS | Hefei TianRui Pharmaceutical Chemical Co., Ltd. | |
 |
2022-02-09 | Benzaldehyde
151103-09-2
|
US $0.00 / KG | 1KG | 98.9% | 100 tons | Honest Joy Holdings Limited | |
 |
2021-07-13 | 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
151103-09-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
151103-09-2
- US $0.00-0.00 / kg
- 99.9%HPLC; USP42
- Hefei TianRui Pharmaceutical Chemical Co., Ltd.
-
- Benzaldehyde
151103-09-2
- US $0.00 / KG
- 98.9%
- Honest Joy Holdings Limited
-
- 4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE
151103-09-2
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
151103-09-2(4-(DIFLUOROMETHOXY)-3-(CYCLOPROPYLMETHOXY)-BENZALDEHYDE)Related Search:
1of4
